Einzeltreffer — DigiBib

Background: The brain is a highly mechanosensitive organ, and changes in the mechanical properties of brain tissue influence many physiological and pathological processes. Piezo type mechanosensitive ion channel component 1 (Piezo1), a protein found in metazoans, is highly expressed in the brain and involved in sensing changes of the mechanical microenvironment. Numerous studies have shown that Piezo1-mediated mechanotransduction is closely related to glial cell activation and neuronal function. However, the precise role of Piezo1 in the brain requires further elucidation.

Objective: This review first discusses the roles of Piezo1-mediated mechanotransduction in regulating the functions of a variety of brain cells, and then briefly assesses the impact of Piezo1-mediated mechanotransduction on the progression of brain dysfunctional disorders.

Conclusions: Mechanical signaling contributes significantly to brain function. Piezo1-mediated mechanotransduction regulates processes such as neuronal differentiation, cell migration, axon guidance, neural regeneration, and oligodendrocyte axon myelination. Additionally, Piezo1-mediated mechanotransduction plays significant roles in normal aging and brain injury, as well as the development of various brain diseases, including demyelinating diseases, Alzheimer's disease, and brain tumors. Investigating the pathophysiological mechanisms through which Piezo1-mediated mechanotransduction affects brain function will give us a novel entry point for the diagnosis and treatment of numerous brain diseases.

Titel:	Mechanical properties of the brain: Focus on the essential role of Piezo1-mediated mechanotransduction in the CNS.
Autor/in / Beteiligte Person:	Zheng, Q ; Liu, H ; Yu, W ; Dong, Y ; Zhou, L ; Deng, W ; Hua, F
Zeitschrift:	Brain and behavior, Jg. 13 (2023-09-01), Heft 9, S. e3136
Veröffentlichung:	Hoboken, NJ : John Wiley & Sons, 2023
Medientyp:	academicJournal
ISSN:	2162-3279 (electronic)
DOI:	10.1002/brb3.3136
Schlagwort:	Humans Axons Brain Neoplasms Neurons Tumor Microenvironment Brain metabolism Mechanotransduction, Cellular
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review Language: English [Brain Behav] 2023 Sep; Vol. 13 (9), pp. e3136. <i>Date of Electronic Publication: </i>2023 Jun 27. MeSH Terms: Brain* / metabolism ; Mechanotransduction, Cellular* ; Humans ; Axons ; Brain Neoplasms ; Neurons ; Tumor Microenvironment References: Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):E5114-22. (PMID: 25385580) ; Biophys J. 2017 Jan 10;112(1):31-45. (PMID: 28076814) ; PLoS One. 2012;7(7):e40346. (PMID: 22792288) ; Channels (Austin). 2012 Jul-Aug;6(4):282-9. (PMID: 22790451) ; Acta Neuropathol. 2010 Jan;119(1):7-35. (PMID: 20012068) ; Neuron. 2023 Jan 4;111(1):15-29.e8. (PMID: 36368316) ; Science. 2005 Nov 18;310(5751):1139-43. (PMID: 16293750) ; J Neurosci. 2004 Apr 14;24(15):3801-9. (PMID: 15084661) ; Nature. 2015 Nov 5;527(7576):64-9. (PMID: 26390154) ; Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6264-9. (PMID: 20308580) ; Glia. 2020 Feb;68(2):356-375. (PMID: 31596529) ; Nat Rev Drug Discov. 2010 Mar;9(3):237-48. (PMID: 20190788) ; Cancer Cell. 2019 Mar 18;35(3):347-367. (PMID: 30889378) ; Biophys J. 2012 Feb 8;102(3):452-60. (PMID: 22325267) ; J Gen Physiol. 2022 Oct 3;154(10):. (PMID: 36069933) ; J Neurosurg. 2020 Feb 28;134(3):893-901. (PMID: 32109875) ; Cell. 2017 Jun 15;169(7):1276-1290.e17. (PMID: 28602351) ; Open J Biophys. 2015 Jul;5(3):80-83. (PMID: 27239390) ; Sci Rep. 2020 Sep 30;10(1):16121. (PMID: 32999349) ; Elife. 2017 Dec 12;6:. (PMID: 29231809) ; Neuron. 2019 Apr 17;102(2):373-389.e6. (PMID: 30819546) ; Nat Commun. 2017 Mar 20;8:14787. (PMID: 28317912) ; Sci STKE. 2001 Jul 10;2001(90):re1. (PMID: 11752662) ; Nature. 2018 Feb 22;554(7693):481-486. (PMID: 29261642) ; Biomaterials. 2009 Sep;30(27):4567-72. (PMID: 19500834) ; BMC Neurosci. 2009 Oct 21;10:128. (PMID: 19845964) ; Nat Commun. 2021 Jun 22;12(1):3845. (PMID: 34158506) ; Life Sci. 2022 May 15;297:120470. (PMID: 35283177) ; Nat Med. 2020 Jan;26(1):131-142. (PMID: 31932797) ; Biochem Biophys Res Commun. 2019 May 21;513(1):147-153. (PMID: 30948157) ; Nature. 2017 Jan 26;541(7638):481-487. (PMID: 28099414) ; Exp Eye Res. 2021 Mar;204:108445. (PMID: 33465396) ; Arch Biochem Biophys. 2020 Feb 15;680:108221. (PMID: 31816310) ; Sci Signal. 2015 Feb 10;8(363):ra15. (PMID: 25670203) ; Nature. 2014 Dec 4;516(7529):121-5. (PMID: 25471886) ; Nat Commun. 2018 Apr 3;9(1):1300. (PMID: 29610524) ; Elife. 2015 Dec 08;4:. (PMID: 26646186) ; Curr Top Membr. 2007;59:81-109. (PMID: 25168134) ; Brain Res. 2006 Sep 7;1108(1):19-27. (PMID: 16854388) ; Dev Neurobiol. 2012 Jul;72(7):1068-84. (PMID: 22489086) ; Nature. 2019 Sep;573(7773):230-234. (PMID: 31435018) ; Immunity. 2018 Jan 16;48(1):59-74.e5. (PMID: 29343440) ; J Cell Sci. 2010 Jan 1;123(Pt 1):51-61. (PMID: 20016066) ; Nat Commun. 2019 Mar 13;10(1):1200. (PMID: 30867417) ; Science. 2002 Jul 19;297(5580):353-6. (PMID: 12130773) ; J Immunol. 2018 Feb 15;200(4):1255-1260. (PMID: 29330322) ; J Magn Reson Imaging. 2011 Sep;34(3):494-8. (PMID: 21751286) ; Aging Cell. 2008 Aug;7(4):590-8. (PMID: 18462272) ; Nat Neurosci. 2019 Dec;22(12):2087-2097. (PMID: 31768052) ; iScience. 2023 Jan 16;26(2):105993. (PMID: 36798430) ; Nature. 2011 Jun 08;474(7350):179-83. (PMID: 21654799) ; Nature. 2002 May 2;417(6884):39-44. (PMID: 11986659) ; J Neurosci. 2007 Mar 28;27(13):3366-74. (PMID: 17392452) ; Sci Rep. 2015 Feb 10;5:8364. (PMID: 25666479) ; Nature. 2017 Mar 2;543(7643):118-121. (PMID: 28199303) ; Sci Adv. 2021 Jul 7;7(28):. (PMID: 34233878) ; Biophys J. 2000 Jul;79(1):144-52. (PMID: 10866943) ; Science. 1993 May 21;260(5111):1124-7. (PMID: 7684161) ; Glia. 2023 Apr;71(4):848-865. (PMID: 36447422) ; Cell Mol Life Sci. 2015 Apr;72(7):1303-16. (PMID: 25504084) ; Glia. 2022 Dec;70(12):2276-2289. (PMID: 35903933) ; Elife. 2015 May 22;4:. (PMID: 26001275) ; Glia. 1993 Jan;7(1):111-8. (PMID: 8423058) ; Mol Cell Biochem. 2020 Nov;474(1-2):189-197. (PMID: 32734537) ; Front Aging Neurosci. 2021 Jul 30;13:709620. (PMID: 34393762) ; Nat Commun. 2021 Jun 10;12(1):3519. (PMID: 34112781) ; Front Cell Neurosci. 2018 Feb 21;12:25. (PMID: 29515372) ; Nat Rev Neurosci. 2008 Nov;9(11):839-55. (PMID: 18931697) ; Nature. 2019 Sep;573(7772):130-134. (PMID: 31413369) ; Cardiovasc Res. 2022 Dec 9;118(15):3052-3070. (PMID: 34734981) ; J Cell Sci. 1995 Aug;108 ( Pt 8):2747-60. (PMID: 7593316) ; Nature. 2012 Feb 19;483(7388):176-81. (PMID: 22343900) ; Adv Sci (Weinh). 2018 Nov 10;6(1):1801638. (PMID: 30643730) ; Mol Ther. 2022 Oct 5;30(10):3241-3256. (PMID: 35619555) ; Trends Neurosci. 2021 Feb;44(2):110-121. (PMID: 33203515) ; Neuron. 2018 Nov 21;100(4):799-815.e7. (PMID: 30344046) ; J Biomech Eng. 2010 Jan;132(1):011010. (PMID: 20524748) ; Nature. 2012 Apr 15;484(7395):546-9. (PMID: 22504183) ; J Orthop Res. 1997 Mar;15(2):318-22. (PMID: 9167638) ; Front Cell Neurosci. 2022 May 26;16:914985. (PMID: 35722613) ; Cell Rep. 2016 Nov 8;17(7):1739-1746. (PMID: 27829145) ; Neurosurgery. 2015 Oct;77(4):653-8; discussion 658-9. (PMID: 26197204) ; J Biol Chem. 2021 Jan-Jun;296:100171. (PMID: 33298523) ; Nat Rev Neurosci. 2010 Apr;11(4):275-83. (PMID: 20216548) ; J Biomed Mater Res A. 2004 Aug 1;70(2):194-205. (PMID: 15227664) ; Nat Commun. 2014 Mar 24;5:3520. (PMID: 24662763) ; Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16148-53. (PMID: 25349416) ; Biomaterials. 2014 Apr;35(13):3919-25. (PMID: 24529901) ; Semin Cell Dev Biol. 2017 Nov;71:3-12. (PMID: 28676421) ; Science. 2010 Oct 1;330(6000):55-60. (PMID: 20813920) ; Sci Rep. 2014 Aug 28;4:6215. (PMID: 25163607) ; Nature. 2022 Apr;604(7905):377-383. (PMID: 35388220) ; Elife. 2017 Jan 30;6:. (PMID: 28135189) ; Front Cell Dev Biol. 2022 Mar 28;10:823857. (PMID: 35419366) ; AJNR Am J Neuroradiol. 2020 Aug;41(8):1423-1429. (PMID: 32675337) ; Nat Cell Biol. 2021 Jul;23(7):771-781. (PMID: 34239060) ; Nat Rev Clin Oncol. 2021 May;18(5):280-296. (PMID: 33514910) ; Neuron. 2022 Sep 21;110(18):2891-2893. (PMID: 36137517) ; Front Physiol. 2022 Dec 14;13:891759. (PMID: 36589456) ; J Biol Chem. 1994 Nov 18;269(46):28551-4. (PMID: 7961799) ; Nat Rev Mol Cell Biol. 2009 Jan;10(1):44-52. (PMID: 19197331) ; Biomacromolecules. 2020 Dec 14;21(12):4962-4971. (PMID: 33112592) ; Glia. 2023 May;71(5):1233-1246. (PMID: 36598105) ; Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16124-9. (PMID: 25349433) ; Elife. 2017 Jan 26;6:. (PMID: 28124973) ; Neuroimage Clin. 2015 Dec 19;10:283-90. (PMID: 26900568) ; Cancer Discov. 2017 Nov;7(11):1224-1237. (PMID: 29038232) ; Neurosci Res. 2000 Oct;38(2):217-20. (PMID: 11000450) ; Nat Commun. 2014 May 06;5:3792. (PMID: 24797322) ; Small. 2022 Jun;18(23):e2201123. (PMID: 35555970) ; Nature. 2018 Feb 22;554(7693):487-492. (PMID: 29469092) ; J Phys Condens Matter. 2010 May 19;22(19):194114. (PMID: 21386440) ; Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15427-30. (PMID: 20713738) ; Nat Rev Neurosci. 2010 May;11(5):361-70. (PMID: 20216546) ; J Cell Sci. 2017 Jan 1;130(1):71-82. (PMID: 28043968) ; Nat Cell Biol. 2016 Dec;18(12):1336-1345. (PMID: 27820599) ; Nat Neurosci. 2016 Dec;19(12):1592-1598. (PMID: 27643431) ; Small. 2020 Sep;16(37):e2003656. (PMID: 32790058) ; Neurology. 1984 Jul;34(7):939-44. (PMID: 6610841) ; Nature. 2019 Sep;573(7772):69-74. (PMID: 31435009) ; Membranes (Basel). 2023 Jan 29;13(2):. (PMID: 36837670) ; Front Aging Neurosci. 2018 Oct 22;10:332. (PMID: 30405400) ; J Biol Chem. 2005 Apr 29;280(17):17294-300. (PMID: 15722360) ; Lancet. 1991 Dec 7;338(8780):1422-3. (PMID: 1683421) ; J Clin Invest. 2020 May 1;130(5):2527-2541. (PMID: 31999644) ; Biophys J. 2005 Apr;88(4):2706-13. (PMID: 15681641) ; Sci Rep. 2019 Jan 30;9(1):999. (PMID: 30700777) ; Biophys J. 2008 Nov 1;95(9):4426-38. (PMID: 18658232) ; Nat Rev Mol Cell Biol. 2017 Dec;18(12):771-783. (PMID: 28974772) ; Annu Rev Biomed Eng. 2013;15:227-51. (PMID: 23642242) ; Glia. 2006 Nov 15;54(7):716-725. (PMID: 17006900) ; J Neurosci. 2009 Aug 26;29(34):10582-7. (PMID: 19710311) ; Front Immunol. 2022 Jan 26;13:816149. (PMID: 35154133) ; N Engl J Med. 2018 Jan 11;378(2):169-180. (PMID: 29320652) ; Glia. 2017 Feb;65(2):360-374. (PMID: 27807898) ; Sci Rep. 2018 Sep 24;8(1):14267. (PMID: 30250223) ; Nat Commun. 2020 Nov 30;11(1):6133. (PMID: 33257673) ; Sci Immunol. 2020 Aug 21;5(50):. (PMID: 32826342) ; Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12980-12985. (PMID: 31186359) ; Glia. 2020 Jan;68(1):145-160. (PMID: 31433095) ; J Neurosurg. 1988 Aug;69(2):155-70. (PMID: 3292716) ; J Alzheimers Dis. 2010;22(3):741-63. (PMID: 20847424) ; PLoS One. 2012;7(9):e41024. (PMID: 23028423) ; Curr Opin Neurobiol. 2012 Oct;22(5):844-9. (PMID: 22560511) ; J Neurosci. 2002 Apr 1;22(7):2451-9. (PMID: 11923409) ; Nat Rev Neurosci. 2012 Dec;13(12):867-78. (PMID: 23165263) ; Cereb Cortex. 2016 May;26(5):2299-2310. (PMID: 26679195) ; Nat Neurosci. 2019 Mar;22(3):484-491. (PMID: 30692691) ; Neural Regen Res. 2023 Jun;18(6):1229-1234. (PMID: 36453398) ; Front Cell Neurosci. 2020 Nov 05;14:590500. (PMID: 33250714) ; Life Sci. 2021 Jan 1;264:118667. (PMID: 33127514) ; Brain Behav. 2023 Sep;13(9):e3136. (PMID: 37366640) ; Biochim Biophys Acta Biomembr. 2018 Sep;1860(9):1663-1669. (PMID: 29679539) ; J Clin Invest. 2016 Dec 1;126(12):4527-4536. (PMID: 27797339) ; Brain Inj. 1999 Jul;13(7):489-504. (PMID: 10462147) ; J Neuroinflammation. 2022 Jun 15;19(1):147. (PMID: 35706029) ; Med Hypotheses. 2021 Jan;146:110327. (PMID: 33277104) ; Biochem Biophys Res Commun. 2022 Jun 4;607:138-145. (PMID: 35367826) ; Free Radic Biol Med. 2015 Feb;79:269-80. (PMID: 25532934) ; J Biol Chem. 2015 Feb 20;290(8):5167-5173. (PMID: 25561736) ; Oxid Med Cell Longev. 2021 Feb 10;2021:8884922. (PMID: 33628392) ; Neuron. 2023 Jan 4;111(1):30-48.e14. (PMID: 36323321) ; Circ Res. 2022 May 13;130(10):1531-1546. (PMID: 35382561) ; Neural Regen Res. 2023 Aug;18(8):1750-1756. (PMID: 36751801) ; Neuron. 2022 Sep 21;110(18):2984-2999.e8. (PMID: 35963237) Contributed Indexing: Keywords: Alzheimer's disease; Piezo1; aging; brain cells; demyelinating disease; mechanotransduction Substance Nomenclature: 0 (PIEZO1 protein, human) Entry Date(s): Date Created: 20230627 Date Completed: 20230915 Latest Revision: 20230915 Update Code: 20240514 PubMed Central ID: PMC10498085

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Mechanical properties of the brain: Focus on the essential role of Piezo1-mediated mechanotransduction in the CNS.