Chemical composition, anti-inflammatory and cytotoxic activity of essential oils from two Luvunga species ( L. scandens and L. hongiaoensis ) from Vietnam.

Trinh Thi, D ; Luong Van, D ; et al.

In: Natural product research, Jg. 38 (2024-06-01), Heft 11, S. 1834-1843

academicJournal

New essential oils (EOs) extracted from different parts of two Luvunga species ( L. scandens and L. hongiaoensis ) from Vietnam were investigated for their chemical composition, anti-inflammatory and cytotoxic activity. Sixty-nine total compounds were identified in the EOs by GC/MS. The major constituent of the leaf, fruit, and root EOs from L. scandens was β-caryophyllene (71.5%, 63.0%, and 31.5% respectively). The main compounds in L. hongiaoensis EOs were β-elemene (34.3% in leaf oil) and caryophyllene oxide (21.2% in root oil, 19.4% in stem oil). The EO from L. scandens fruits significantly inhibited nitric oxide production on LPS-induced RAW264.7 cells (IC 50 = 37.95 ± 2.76 µg/mL). The EOs from L. hongiaoensis roots and L. scandens leaves and fruits exhibited cytotoxic activity against MCF-7, SK-LU-1, and HepG2 (IC 50 from 49.74 ± 3.36 to 97.82 ± 8.61 µg/mL). This is the first report on L. hongiaoensis EOs and significantly complements the composition and bioactivity of L. scandens EOs.

Titel:	Chemical composition, anti-inflammatory and cytotoxic activity of essential oils from two Luvunga species ( L. scandens and L. hongiaoensis ) from Vietnam.
Autor/in / Beteiligte Person:	Trinh Thi, D ; Luong Van, D ; Phung Van, T ; Nguyen Thi, H ; Do Thi, T ; Nguyen Thi To, U ; Tran Thi Hoai, L ; Dang Vinh, K ; Huynh, TT ; Le Thi Thanh, T
Zeitschrift:	Natural product research, Jg. 38 (2024-06-01), Heft 11, S. 1834-1843
Veröffentlichung:	Milton Park, UK : Taylor & Francis Health Sciences, c2003-, 2024
Medientyp:	academicJournal
ISSN:	1478-6427 (electronic)
DOI:	10.1080/14786419.2023.2225125
Schlagwort:	Mice Humans Vietnam Animals RAW 264.7 Cells Fruit chemistry Antineoplastic Agents, Phytogenic pharmacology Antineoplastic Agents, Phytogenic chemistry Hep G2 Cells Gas Chromatography-Mass Spectrometry MCF-7 Cells Cell Line, Tumor Oils, Volatile pharmacology Oils, Volatile chemistry Anti-Inflammatory Agents pharmacology Anti-Inflammatory Agents chemistry Plant Leaves chemistry Sesquiterpenes pharmacology Sesquiterpenes chemistry Polycyclic Sesquiterpenes pharmacology Polycyclic Sesquiterpenes chemistry Nitric Oxide Plant Roots chemistry
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Nat Prod Res] 2024 Jun; Vol. 38 (11), pp. 1834-1843. <i>Date of Electronic Publication: </i>2023 Jun 19. MeSH Terms: Oils, Volatile* / pharmacology ; Oils, Volatile* / chemistry ; Anti-Inflammatory Agents* / pharmacology ; Anti-Inflammatory Agents* / chemistry ; Plant Leaves* / chemistry ; Sesquiterpenes* / pharmacology ; Sesquiterpenes* / chemistry ; Polycyclic Sesquiterpenes* / pharmacology ; Polycyclic Sesquiterpenes* / chemistry ; Nitric Oxide* ; Plant Roots* / chemistry ; Mice ; Humans ; Vietnam ; Animals ; RAW 264.7 Cells ; Fruit / chemistry ; Antineoplastic Agents, Phytogenic / pharmacology ; Antineoplastic Agents, Phytogenic / chemistry ; Hep G2 Cells ; Gas Chromatography-Mass Spectrometry ; MCF-7 Cells ; Cell Line, Tumor Contributed Indexing: Keywords: GC/MS; Luvunga hongiaoensis; Luvunga scandens; NO inhibition; cytotoxicity; essential oil Substance Nomenclature: 0 (Oils, Volatile) ; 0 (Anti-Inflammatory Agents) ; 0 (Sesquiterpenes) ; 0 (Polycyclic Sesquiterpenes) ; 31C4KY9ESH (Nitric Oxide) ; S2XU9K448U (caryophyllene oxide) ; BHW853AU9H (caryophyllene) ; 0 (beta-elemene) ; 0 (Antineoplastic Agents, Phytogenic) Entry Date(s): Date Created: 20230620 Date Completed: 20240513 Latest Revision: 20240513 Update Code: 20240514

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