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Background: Although essential tremor (ET) is associated with cognitive decline, we know little about how specific cognitive changes predict significant events in patients' lives. We examined the relations of attention, executive function, language, memory, and visuospatial performance to the occurrence of near falls, falls, walking aid use, home health aide use, non-independent living and hospitalizations within a prospective, longitudinal study of ET cases. We expected executive function and memory to be most strongly associated with these events.

Methods: 131 ET cases (mean age at baseline = 76.4 ± 9.4 years; 109 normal cognition; 17 mild cognitive impairment, 5 demented) completed questionnaires (clinical history and occurrence of life events) and a battery of neuropsychological tests at baseline and at 18, 36, and 54 months. We assessed associations between cognitive functioning and outcomes via regression equations.

Results: Cases with lower baseline levels of executive function reported more near falls, p < 0.006, and were more likely to use a walking aid, p < 0.03, odds ratio (OR) = 2.89 during the follow-up period, than were other cases. Decline in executive function was associated with home health aide use during follow-up, p < 0.04, OR = 3.34. Baseline visuospatial performance also bore a marginally significant association with non-independent living arrangements during follow-up, p < 0.06, OR = 2.13. These effects were independent of age and tremor severity.

Conclusion: These data establish the important role that cognitive decline, and executive function specifically, play in the experiences of ET patients. Moreover, these associations are of sufficient magnitude to have significant clinical implications.

Competing Interests: Declaration of Competing Interest None.

Titel:	Associations between cognitive function and a range of significant life events in an elderly essential tremor cohort study.
Autor/in / Beteiligte Person:	Berry, DS ; Nguyen, D ; Cosentino, S ; Louis, ED
Zeitschrift:	Journal of the neurological sciences, Jg. 450 (2023-07-15), S. 120675
Veröffentlichung:	Amsterdam : Elsevier, <19 ->, 2023
Medientyp:	academicJournal
ISSN:	1878-5883 (electronic)
DOI:	10.1016/j.jns.2023.120675
Schlagwort:	Humans Aged Aged, 80 and over Cohort Studies Longitudinal Studies Prospective Studies Cognition Executive Function Neuropsychological Tests Essential Tremor complications Cognitive Dysfunction psychology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural Language: English [J Neurol Sci] 2023 Jul 15; Vol. 450, pp. 120675. <i>Date of Electronic Publication: </i>2023 May 11. MeSH Terms: Essential Tremor* / complications ; Cognitive Dysfunction* / psychology ; Humans ; Aged ; Aged, 80 and over ; Cohort Studies ; Longitudinal Studies ; Prospective Studies ; Cognition ; Executive Function ; Neuropsychological Tests References: J Am Geriatr Soc. 1988 Jul;36(7):613-6. (PMID: 3385114) ; Tremor Other Hyperkinet Mov (N Y). 2022 Oct 07;12:30. (PMID: 36303814) ; Trans Am Neurol Assoc. 1968;93:38-42. (PMID: 5711050) ; Neurology. 2001 Sep 11;57(5):785-90. (PMID: 11552004) ; J Am Geriatr Soc. 2005 Dec;53(12):2190-4. (PMID: 16398908) ; J Alzheimers Dis. 2018;66(3):1245-1254. (PMID: 30412500) ; Alzheimers Dement. 2021 Oct;17(10):1698-1708. (PMID: 33991041) ; Parkinsonism Relat Disord. 2022 May;98:16-20. (PMID: 35421780) ; Front Neurol. 2017 Apr 19;8:154. (PMID: 28469597) ; Gait Posture. 2012 Jan;35(1):43-7. (PMID: 21930384) ; J Am Geriatr Soc. 1990 Dec;38(12):1321-5. (PMID: 2254571) ; Neurology. 1993 Nov;43(11):2412-4. (PMID: 8232972) ; Arch Neurol. 1999 Jul;56(7):841-6. (PMID: 10404986) ; J Int Neuropsychol Soc. 2002 Jan;8(1):125-9. (PMID: 11843070) ; Ther Adv Neurol Disord. 2013 Nov;6(6):353-68. (PMID: 24228071) ; Int J Endocrinol. 2015;2015:210527. (PMID: 26273292) ; Alzheimers Res Ther. 2017 Sep 20;9(1):75. (PMID: 28931428) ; Mov Disord. 1998 Mar;13(2):287-93. (PMID: 9539343) ; Eur J Neurol. 2013 Apr;20(4):725-7. (PMID: 22925197) ; Tremor Other Hyperkinet Mov (N Y). 2019 Jun 19;9:. (PMID: 31413894) ; Neurology. 2007 Nov 20;69(21):1982-9. (PMID: 18025392) ; Parkinsonism Relat Disord. 2012 Jan;18 Suppl 1:S140-2. (PMID: 22166415) ; Neurology. 2009 Aug 25;73(8):621-5. (PMID: 19704081) ; Acta Neurol Belg. 2015 Sep;115(3):281-7. (PMID: 25471376) ; Mov Disord. 2007 Aug 15;22(11):1573-80. (PMID: 17516478) ; Geriatr Gerontol Int. 2017 Oct;17(10):1477-1480. (PMID: 27577092) ; Parkinsonism Relat Disord. 2016 Jan;22 Suppl 1:S115-8. (PMID: 26343494) ; Arch Phys Med Rehabil. 2014 Oct;95(10):1832-7. (PMID: 24769121) ; BMC Geriatr. 2023 Mar 10;23(1):140. (PMID: 36899323) ; Parkinsonism Relat Disord. 2019 Jun;63:10-19. (PMID: 30876840) ; Anat Sci Educ. 2017 Sep;10(5):475-486. (PMID: 28264142) ; J Am Geriatr Soc. 2012 Nov;60(11):2127-36. (PMID: 23110433) ; Tremor Other Hyperkinet Mov (N Y). 2012;2:. (PMID: 23440004) ; Dement Geriatr Cogn Disord. 2013;36(1-2):20-35. (PMID: 23712088) ; Dement Geriatr Cogn Disord. 2019;48(1-2):17-29. (PMID: 31743907) ; Parkinsonism Relat Disord. 2012 Jun;18(5):407-13. (PMID: 22217558) ; J Neurol Sci. 2021 Sep 15;428:117563. (PMID: 34274879) Grant Information: R01 NS086736 United States NS NINDS NIH HHS Contributed Indexing: Keywords: Cognition; Essential tremor; Executive function; Falls; Significant life events Entry Date(s): Date Created: 20230517 Date Completed: 20230613 Latest Revision: 20231219 Update Code: 20231219 PubMed Central ID: PMC10727135

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Associations between cognitive function and a range of significant life events in an elderly essential tremor cohort study.