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Objective: Essential hypertension (EH) is a common cardiovascular disease that endangers human health. Its pathogenesis is complex and has not been fully elucidated. We explore the association between EH and interactions among polymorphisms of the angiotensin converting enzyme (ACE) gene in the Hefei region, Anhui, China.

Methods: A total of 500 participants (400 hypertensive and 100 normotensive) were included in this study. The polymorphisms were detected via improved multiple ligase detection reaction (iMLDR). To improve the accuracy of prediction, multifactor dimensionality reduction (MDR) was used to analyze the overall effect of interactions among seven loci on the incidence of EH.

Results: The frequencies of polymorphisms in the ACE genes rs12709426, rs4291, rs4309, rs4331, rs4343, rs4459609, and rs4461142 in the EH group were not statistically significantly different from those in the control group. We also found that the single nucleotide polymorphism (SNP) rs12709426 only had a homozygous AA genotype and no polymorphisms. There were no differences in the frequency of genetic polymorphisms between the EH and control groups. The best model explaining the EH group was the combined effect of ACE genes rs4291, rs4309, and rs4461142.

Conclusion: There is an interaction effect among ACE gene loci in EH patients in Hefei region, Anhui, China. Also, the ACE gene SNP rs12709426 only has a homozygous AA genotype and does not show an association with EH.

Competing Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Titel:	Association between Interactions among ACE Gene Polymorphisms and Essential Hypertension in Patients in the Hefei Region, Anhui, China.
Autor/in / Beteiligte Person:	Wang, L ; Song, TT ; Dong, CW
Zeitschrift:	Journal of the renin-angiotensin-aldosterone system : JRAAS, Jg. 2023 (2023-04-13), S. 1159973
Veröffentlichung:	2021- : [London] : Hindawi in collaboration with SAGE Publishing ; <i>Original Publication</i>: Birmingham, England : JRAAS Ltd., [2000?]-, 2023
Medientyp:	academicJournal
ISSN:	1752-8976 (electronic)
DOI:	10.1155/2023/1159973
Schlagwort:	Humans Gene Frequency genetics Genetic Predisposition to Disease Essential Hypertension genetics Polymorphism, Single Nucleotide genetics China epidemiology Genotype Peptidyl-Dipeptidase A genetics Hypertension genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [J Renin Angiotensin Aldosterone Syst] 2023 Apr 13; Vol. 2023, pp. 1159973. <i>Date of Electronic Publication: </i>2023 Apr 13 (<i>Print Publication: </i>2023). MeSH Terms: Peptidyl-Dipeptidase A* / genetics ; Hypertension* / genetics ; Humans ; Gene Frequency / genetics ; Genetic Predisposition to Disease ; Essential Hypertension / genetics ; Polymorphism, Single Nucleotide / genetics ; China / epidemiology ; Genotype References: Croat Med J. 2016 Aug 31;57(4):371-80. (PMID: 27586552) ; Exp Mol Pathol. 2014 Aug;97(1):166-70. (PMID: 24995885) ; Acta Med Port. 2018 Oct 31;31(10):542-550. (PMID: 30387422) ; Int J Mol Sci. 2016 Mar 25;17(4):451. (PMID: 27023534) ; Curr Pharm Des. 2011;17(28):2973-86. (PMID: 21861838) ; Clin Exp Hypertens. 2019;41(1):70-74. (PMID: 29546999) ; BMC Med Genomics. 2022 Feb 8;15(1):22. (PMID: 35130889) ; Bratisl Lek Listy. 2012;113(1):14-8. (PMID: 22380495) ; J Renin Angiotensin Aldosterone Syst. 2021 Jan-Dec;22(1):1470320321995074. (PMID: 33726555) ; Rev Assoc Med Bras (1992). 2019 Jul 22;65(6):923-929. (PMID: 31340327) ; Curr Hypertens Rep. 2020 Jun 26;22(7):45. (PMID: 32591971) ; J Hypertens. 1999 Feb;17(2):151-83. (PMID: 10067786) ; J Stroke Cerebrovasc Dis. 2021 Mar;30(3):105579. (PMID: 33412396) ; J Hypertens. 2009 Jul;27(7):1384-91. (PMID: 19412130) ; J Renin Angiotensin Aldosterone Syst. 2013 Dec;14(4):348-53. (PMID: 23042814) ; Hypertens Res. 2007 Jan;30(1):31-7. (PMID: 17460369) ; Heart Asia. 2016 May 19;8(1):83-9. (PMID: 27326240) ; Intern Med J. 2012 Apr;42(4):439-44. (PMID: 21883781) ; J Renin Angiotensin Aldosterone Syst. 2015 Dec;16(4):975-81. (PMID: 26283679) ; Clin Lab. 2013;59(1-2):85-92. (PMID: 23505911) ; J Hum Hypertens. 2009 Apr;23(4):227-37. (PMID: 19005475) ; Arch Med Res. 2017 Jan;48(1):88-95. (PMID: 28577874) ; Clin Exp Hypertens. 2016;38(1):63-70. (PMID: 26305278) ; Genet Mol Res. 2014 Oct 20;13(4):8385-95. (PMID: 25366732) ; Mol Biol Rep. 2023 Feb;50(2):1487-1497. (PMID: 36507965) ; Curr Opin Nephrol Hypertens. 1994 Jan;3(1):25-9. (PMID: 7850408) ; Clin Exp Hypertens. 2018;40(1):32-38. (PMID: 29172745) ; Acta Med Indones. 2012 Oct;44(4):280-3. (PMID: 23314967) ; PLoS One. 2013;8(3):e56119. (PMID: 23469169) ; Medicine (Baltimore). 2020 Jun 5;99(23):e20552. (PMID: 32502021) ; Trends Pharmacol Sci. 2002 Apr;23(4):177-83. (PMID: 11931993) Substance Nomenclature: EC 3.4.15.1 (Peptidyl-Dipeptidase A) Entry Date(s): Date Created: 20230424 Date Completed: 20230425 Latest Revision: 20230425 Update Code: 20240514 PubMed Central ID: PMC10118893

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Association between Interactions among ACE Gene Polymorphisms and Essential Hypertension in Patients in the Hefei Region, Anhui, China.