Zum Hauptinhalt springen
Hochschulbibliothek Niederrhein

RNA localization to the mitotic spindle is essential for early development and is regulated by kinesin-1 and dynein.

Remsburg, CM ; Konrad, KD ; et al.
In: Journal of cell science, Jg. 136 (2023-03-01), Heft 5
academicJournal

Mitosis is a fundamental and highly regulated process that acts to faithfully segregate chromosomes into two identical daughter cells. Localization of gene transcripts involved in mitosis to the mitotic spindle might be an evolutionarily conserved mechanism to ensure that mitosis occurs in a timely manner. We identified many RNA transcripts that encode proteins involved in mitosis localized at the mitotic spindles in dividing sea urchin embryos and mammalian cells. Disruption of microtubule polymerization, kinesin-1 or dynein results in lack of spindle localization of these transcripts in the sea urchin embryo. Furthermore, results indicate that the cytoplasmic polyadenylation element (CPE) within the 3'UTR of the Aurora B transcript, a recognition sequence for CPEB, is essential for RNA localization to the mitotic spindle in the sea urchin embryo. Blocking this sequence results in arrested development during early cleavage stages, suggesting that RNA localization to the mitotic spindle might be a regulatory mechanism of cell division that is important for early development.

Competing Interests: Competing interests The authors declare no competing or financial interests.

(© 2023. Published by The Company of Biologists Ltd.)

Titel:
RNA localization to the mitotic spindle is essential for early development and is regulated by kinesin-1 and dynein.
Autor/in / Beteiligte Person: Remsburg, CM ; Konrad, KD ; Song, JL
Zeitschrift: Journal of cell science, Jg. 136 (2023-03-01), Heft 5
Veröffentlichung: Cambridge : Company of Biologists ; <i>Original Publication</i>: London., 2023
Medientyp: academicJournal
ISSN: 1477-9137 (electronic)
DOI: 10.1242/jcs.260528
Schlagwort:
  • Animals
  • Spindle Apparatus metabolism
  • Mitosis
  • RNA metabolism
  • Microtubules metabolism
  • Mammals metabolism
  • Kinesins metabolism
  • Dyneins metabolism
Sonstiges:
  • Nachgewiesen in: MEDLINE
  • Sprachen: English
  • Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • Language: English
  • [J Cell Sci] 2023 Mar 01; Vol. 136 (5). <i>Date of Electronic Publication: </i>2023 Mar 06.
  • MeSH Terms: Kinesins* / metabolism ; Dyneins* / metabolism ; Animals ; Spindle Apparatus / metabolism ; Mitosis ; RNA / metabolism ; Microtubules / metabolism ; Mammals / metabolism
  • References: Curr Biol. 2002 Dec 10;12(23):1971-81. (PMID: 12477385) ; J Cell Sci. 1992 Jul;102 ( Pt 3):387-92. (PMID: 1506421) ; Curr Biol. 2004 Sep 21;14(18):R797-805. (PMID: 15380094) ; Dev Cell. 2008 Sep;15(3):426-436. (PMID: 18771961) ; PLoS One. 2014 Mar 17;9(3):e92349. (PMID: 24637809) ; Mol Biol Cell. 2005 Jan;16(1):292-305. (PMID: 15509656) ; Mol Cell. 2010 May 14;38(3):383-92. (PMID: 20471944) ; Mol Biol Cell. 2011 Nov;22(22):4312-23. (PMID: 21937723) ; J Exp Zool. 1992 Dec 1;264(3):312-22. (PMID: 1358997) ; PLoS One. 2016 Mar 10;11(3):e0150318. (PMID: 26962866) ; Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12383-8. (PMID: 17636127) ; Curr Biol. 2010 Sep 28;20(18):1666-71. (PMID: 20832310) ; Development. 2011 Jul;138(13):2639-48. (PMID: 21652646) ; Biochim Biophys Acta Gene Regul Mech. 2018 Oct;1861(10):938-951. (PMID: 30496039) ; Nat Commun. 2021 Oct 27;12(1):6079. (PMID: 34707124) ; Mol Cell. 2016 Oct 20;64(2):362-375. (PMID: 27768873) ; Genes Dev. 2021 Jul 1;35(13-14):976-991. (PMID: 34140355) ; Zygote. 1997 May;5(2):153-75. (PMID: 9276512) ; J Cell Biol. 2003 Jan 6;160(1):77-87. (PMID: 12507992) ; Nat Commun. 2016 Jan 04;7:10253. (PMID: 26727405) ; EMBO J. 2008 Dec 17;27(24):3235-45. (PMID: 19020519) ; Results Probl Cell Differ. 2017;63:149-168. (PMID: 28779317) ; Science. 2002 Sep 27;297(5590):2232-7. (PMID: 12215653) ; Nature. 1990 Nov 22;348(6299):348-52. (PMID: 2174512) ; J Cell Sci. 2017 May 15;130(10):1760-1771. (PMID: 28404789) ; J Biol Chem. 2008 Feb 22;283(8):4983-92. (PMID: 18079118) ; Nature. 2012 Mar 18;484(7392):125-9. (PMID: 22425997) ; Dev Biol. 2012 Feb 1;362(1):104-13. (PMID: 22155525) ; J Biol Chem. 2021 Sep;297(3):101024. (PMID: 34343568) ; EMBO J. 2011 Aug 31;30(17):3540-52. (PMID: 21878995) ; Nat Genet. 2009 Jul;41(7):854-8. (PMID: 19503091) ; Semin Cell Dev Biol. 2007 Apr;18(2):216-23. (PMID: 17331761) ; Int J Mol Sci. 2017 Aug 31;18(9):. (PMID: 28858266) ; Methods Cell Biol. 2004;74:287-310. (PMID: 15575612) ; Cell. 2002 Oct 18;111(2):163-72. (PMID: 12408861) ; Science. 2002 Sep 13;297(5588):1833-7. (PMID: 12193640) ; Dev Cell. 2021 Nov 22;56(22):3082-3099.e5. (PMID: 34758290) ; EMBO J. 2003 Jun 16;22(12):2934-47. (PMID: 12805209) ; In Vitro. 1976 Oct;12(10):670-7. (PMID: 828141) ; Development. 2015 Jun 1;142(11):1960-70. (PMID: 25977366) ; Mol Biol Cell. 2009 Jun;20(11):2684-96. (PMID: 19369422) ; Development. 2018 Nov 30;145(23):. (PMID: 30389855) ; Cell. 2007 Oct 5;131(1):174-87. (PMID: 17923096) ; Elife. 2017 Aug 01;6:. (PMID: 28760200) ; Nat Rev Mol Cell Biol. 2009 Oct;10(10):682-96. (PMID: 19773780) ; Cell. 2006 Dec 1;127(5):983-97. (PMID: 17129783) ; Oncogene. 2005 Jan 13;24(3):314-25. (PMID: 15678131) ; EMBO J. 2003 Nov 3;22(21):5928-40. (PMID: 14592989) ; Dev Cell. 2018 Jun 4;45(5):637-650.e7. (PMID: 29870721) ; J Cell Biol. 2009 Apr 20;185(2):193-202. (PMID: 19364923) ; Biochem Biophys Res Commun. 2018 Sep 18;503(4):2778-2783. (PMID: 30103945) ; Mol Cell. 2015 Aug 6;59(3):426-36. (PMID: 26190260) ; Nature. 1997 Sep 4;389(6646):90-3. (PMID: 9288973) ; Nat Cell Biol. 2000 Apr;2(4):185-90. (PMID: 10783235) ; Nucleic Acids Res. 2012 Aug;40(15):e115. (PMID: 22730293) ; Elife. 2018 Apr 30;7:. (PMID: 29708497) ; Oncogene. 2007 Jan 11;26(2):165-72. (PMID: 16832348) ; J Cell Biol. 2021 Jan 4;220(1):. (PMID: 33284322) ; Science. 1994 Aug 19;265(5175):1101-3. (PMID: 7520603) ; J Cell Sci. 2020 Jul 23;133(14):. (PMID: 32576666) ; Elife. 2018 May 31;7:. (PMID: 29848445) ; Cell Mol Life Sci. 2021 Dec;78(23):7379-7395. (PMID: 34698881) ; Cell. 2005 Jul 15;122(1):97-106. (PMID: 16009136) ; Trends Cell Biol. 2009 Apr;19(4):174-9. (PMID: 19285869) ; Mol Cell Biol. 1998 Feb;18(2):1055-64. (PMID: 9448003) ; Dev Biol. 2020 Dec 1;468(1-2):55-58. (PMID: 32979335) ; Development. 2015 Nov 1;142(21):3769-80. (PMID: 26400092) ; Nucleic Acids Res. 2022 Jan 7;50(D1):D970-D979. (PMID: 34791383) ; Front Oncol. 2015 Oct 16;5:225. (PMID: 26528436) ; Dev Dyn. 2007 Nov;236(11):3180-90. (PMID: 17948309) ; Trends Cell Biol. 2019 Jan;29(1):66-79. (PMID: 30220581) ; Microsc Res Tech. 2000 Jun 1;49(5):467-77. (PMID: 10842374) ; Genetics. 2012 Apr;190(4):1197-224. (PMID: 22491889) ; Mol Biol Cell. 2006 Feb;17(2):907-16. (PMID: 16339079) ; Evol Dev. 2007 Nov-Dec;9(6):527-39. (PMID: 17976050) ; Dev Biol. 2015 Jun 1;402(1):127-41. (PMID: 25614238) ; J Biol Chem. 2019 Aug 2;294(31):11840-11852. (PMID: 31201269) ; Genes Dev. 2003 Mar 1;17(5):638-53. (PMID: 12629046) ; Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6877-E6886. (PMID: 27791158) ; Cell. 2000 Oct 27;103(3):435-47. (PMID: 11081630) ; J Biol Chem. 2003 Apr 18;278(16):14394-400. (PMID: 12566455) ; Nat Commun. 2021 Mar 11;12(1):1547. (PMID: 33707436) ; Biomolecules. 2019 Feb 07;9(2):. (PMID: 30736436) ; RNA. 2020 Dec 15;:. (PMID: 33323527) ; Mol Biol Cell. 2002 Jun;13(6):1977-2000. (PMID: 12058064) ; Neuron. 2004 Aug 19;43(4):513-25. (PMID: 15312650) ; Mol Biol Cell. 2012 Feb;23(4):567-76. (PMID: 22171325) ; Development. 1993 Mar;117(3):1049-60. (PMID: 8325234) ; EMBO J. 2012 Aug 1;31(15):3351-62. (PMID: 22713866) ; J Neurosci. 2013 Sep 11;33(37):14791-800. (PMID: 24027279) ; J Cell Biol. 2007 Dec 31;179(7):1365-73. (PMID: 18166649) ; EMBO J. 2009 Apr 22;28(8):1157-69. (PMID: 19262563) ; Chromosoma. 2014 Oct;123(5):407-22. (PMID: 24871939) ; Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7045-50. (PMID: 11416185) ; J Biol Chem. 2005 Apr 1;280(13):12658-67. (PMID: 15665380) ; Curr Biol. 2001 Jul 10;11(13):1010-6. (PMID: 11470405) ; Nat Commun. 2022 Apr 20;13(1):2145. (PMID: 35444184) ; Trends Genet. 2002 Dec;18(12):636-42. (PMID: 12446149) ; Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):1540-5. (PMID: 26811472) ; Essays Biochem. 2020 Sep 4;64(2):313-324. (PMID: 32347304) ; Mol Biol Cell. 1998 Dec;9(12):3273-97. (PMID: 9843569) ; Cell Rep. 2020 Mar 10;30(10):3339-3352.e6. (PMID: 32160541) ; Methods Mol Biol. 2014;1128:249-62. (PMID: 24567220) ; Annu Rev Biochem. 2016 Jun 2;85:659-83. (PMID: 27145846) ; Oncogene. 2017 Aug 24;36(34):4819-4827. (PMID: 28436952) ; Nat Ecol Evol. 2016 Dec 05;1(1):5. (PMID: 28812551) ; Mol Cell Biol. 2018 Aug 28;38(18):. (PMID: 29941491) ; Nature. 2007 Apr 19;446(7138):876-81. (PMID: 17443180) ; J Cell Biol. 2019 Feb 4;218(2):395-409. (PMID: 30446607) ; Cold Spring Harb Perspect Biol. 2016 Sep 01;8(9):. (PMID: 27587616) ; Development. 1998 Jul;125(14):2677-85. (PMID: 9636082) ; Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9153-E9162. (PMID: 29073112) ; PLoS One. 2014 Jun 26;9(6):e100748. (PMID: 24968351) ; Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13738-13743. (PMID: 29229862) ; Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13250-5. (PMID: 8917577) ; Dev Biol. 2010 Apr 15;340(2):188-99. (PMID: 19895806) ; Elife. 2017 Nov 29;6:. (PMID: 29185983) ; Cell Rep. 2021 Nov 9;37(6):109783. (PMID: 34758324) ; Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. (PMID: 18669648) ; Dev Neurobiol. 2023 Jan;83(1-2):3-27. (PMID: 36336988) ; Curr Opin Cell Biol. 2006 Apr;18(2):185-91. (PMID: 16488126) ; Mol Biol Cell. 2001 Sep;12(9):2567-77. (PMID: 11553699) ; Cell. 1995 Oct 6;83(1):29-38. (PMID: 7553870) ; Development. 1990 Dec;110(4):1249-61. (PMID: 2151612) ; Dev Cell. 2018 Mar 26;44(6):659-663. (PMID: 29587141) ; Nat Methods. 2012 Jul;9(7):671-5. (PMID: 22930834) ; Nature. 1998 Feb 19;391(6669):792-5. (PMID: 9486649) ; Science. 1992 Feb 21;255(5047):991-4. (PMID: 1546297) ; Nat Cell Biol. 2017 Dec;19(12):1433-1440. (PMID: 29084198) ; J Cell Sci. 1997 Mar;110 ( Pt 6):765-70. (PMID: 9099950) ; Cells Dev. 2021 Mar;165:203660. (PMID: 33842922) ; PLoS Biol. 2010 Apr 06;8(4):e1000350. (PMID: 20386726) ; Comp Biochem Physiol C Toxicol Pharmacol. 2015 Dec;178:8-15. (PMID: 26475527)
  • Grant Information: P20GM103653 United States NH NIH HHS; P20 GM103446 United States GM NIGMS NIH HHS; P20 GM103653 United States GM NIGMS NIH HHS; P20 GM139760 United States GM NIGMS NIH HHS
  • Contributed Indexing: Keywords: Dynein; Embryonic development; Kinesin-1; Mitosis; RNA localization
  • Substance Nomenclature: EC 3.6.4.4 (Kinesins) ; EC 3.6.4.2 (Dyneins) ; 63231-63-0 (RNA)
  • Entry Date(s): Date Created: 20230208 Date Completed: 20230307 Latest Revision: 20240307
  • Update Code: 20240307
  • PubMed Central ID: PMC10038151

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

oder
oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

oder
oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

xs 0 - 576
sm 576 - 768
md 768 - 992
lg 992 - 1200
xl 1200 - 1366
xxl 1366 -