Genetic polymorphisms of purinergic P2Y <subscript>2</subscript> receptor were associated with the susceptibility to essential hypertension in Chinese postmenopausal women.
In: Purinergic signalling, Jg. 19 (2023-12-01), Heft 4, S. 663-671
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Zugriff:
Hypertension has become a prominent public health concern. Essential hypertension (EH) is a polygenic disorder caused by multiple susceptibility genes. It has been previously shown that the purinergic P2Y 2 receptor (P2Y 2 R) regulates blood pressure; however, whether P2Y 2 R genetic polymorphisms correlate with EH has not been investigated in Chinese. Our study included 500 EH cases and 504 controls who are Chinese postmenopausal women. We used allele-specific polymerase chain reaction (ASPCR) to genotype five single-nucleotide polymorphism (SNPs) in the P2Y 2 R gene, i.e., rs4944831, rs12366239, rs1783596, rs4382936, and rs10898909. We assessed the association of P2Y 2 R genetic polymorphisms with EH susceptibility. The results demonstrated that P2Y 2 R rs4382936A was correlated with a high risk of EH; particularly, the participants with the rs4382936A allele and CA/AA/(CA+AA) genotypes were at higher risks to EH compared to the subjects with the rs4382936C allele and CC genotype. Moreover, haplotype CAG combined by rs1783596-rs4382936-rs10898909 was a susceptible haplotype for EH, whereas haplotype CCG was a protective haplotype for EH. These results may provide new evidence for applying P2Y 2 R genetic polymorphisms as useful markers in clinic screening or monitoring potential EH cases in a population of Chinese postmenopausal women.
(© 2023. The Author(s), under exclusive licence to Springer Nature B.V.)
Titel: |
Genetic polymorphisms of purinergic P2Y <subscript>2</subscript> receptor were associated with the susceptibility to essential hypertension in Chinese postmenopausal women.
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Autor/in / Beteiligte Person: | Li, A ; Xiong, C ; Gong, C ; Gou, M ; Wang, Y ; Yang, Y ; Xu, H |
Zeitschrift: | Purinergic signalling, Jg. 19 (2023-12-01), Heft 4, S. 663-671 |
Veröffentlichung: | Dordrecht, the Netherlands : Springer, 2023 |
Medientyp: | academicJournal |
ISSN: | 1573-9546 (electronic) |
DOI: | 10.1007/s11302-023-09921-6 |
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