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Aims: Identification and intervention of left ventricular hypertrophy (LVH) in essential hypertension (EH) are important for the prevention of adverse cardiovascular events. However, effective methods for diagnosing LVH are still lacking. This study aimed to explore the relationship between soluble ST2 (sST2) and LVH in EH patients to identify a potential specific biomarker for hypertensive LVH.

Methods and Results: This study included 97 EH patients. Based on the criteria for LVH, participants were divided into the LVH group (n = 52) and the non-LVH group (n = 45). The level of serum sST2 was detected by enzyme-linked immunosorbent assay. Pearson correlation analysis, logistic regression analysis, and receiver operating characteristic (ROC) curve analysis were used to investigate the potential of sST2 as a biomarker of LVH in EH patients. Compared with the non-LVH group, the sST2 level was elevated in EH patients with LVH (P < 0.001). Pearson correlation analysis indicated that the sST2 level was positively correlated with the left ventricular mass index in EH patients (r = 0.454, P < 0.001). Logistic regression analysis showed that the odds ratio (OR) value of LVH was 2.990, suggesting that sST2 is an independent risk factor for LVH in EH patients [OR = 2.990, 95% confidence interval (CI), 1.650-5.419; P < 0.001]. The area under the ROC curve was 0.767 (95% CI, 0.669-0.866; P < 0.001), with a sensitivity of 0.808 and specificity of 0.689, indicating the possibility of considering sST2 as a biomarker for diagnosing LVH.

Conclusions: Up-regulation of sST2 is strongly related to LVH in EH patients, is an independent risk factor for hypertensive LVH, and can be used as a biomarker for the diagnosis of LVH.

Titel:	Expression of soluble ST2 in patients with essential hypertension and its relationship with left ventricular hypertrophy.
Autor/in / Beteiligte Person:	Wei, P ; Liu, L ; Wang, X ; Zong, B ; Liu, X ; Zhang, M ; Fu, Q ; Wang, L ; Cao, B
Zeitschrift:	ESC heart failure, Jg. 10 (2023-02-01), Heft 1, S. 303-310
Veröffentlichung:	[Oxford] : John Wiley & Sons Ltd on behalf of the European Society of Cardiology, [2014]-, 2023
Medientyp:	academicJournal
ISSN:	2055-5822 (electronic)
DOI:	10.1002/ehf2.14147
Schlagwort:	Humans Biomarkers Essential Hypertension complications Hypertrophy, Left Ventricular Interleukin-1 Receptor-Like 1 Protein blood
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [ESC Heart Fail] 2023 Feb; Vol. 10 (1), pp. 303-310. <i>Date of Electronic Publication: </i>2022 Oct 09. MeSH Terms: Essential Hypertension* / complications ; Hypertrophy, Left Ventricular* ; Interleukin-1 Receptor-Like 1 Protein* / blood ; Humans ; Biomarkers References: Tunis Med. 2019 Feb;97(2):335-343. (PMID: 31539092) ; J Hypertens. 2012 Nov;30(11):2066-73. (PMID: 22914541) ; Tex Heart Inst J. 2017 Dec 19;44(6):385-389. (PMID: 29276436) ; J Am Coll Cardiol. 2001 Dec;38(7):1829-35. (PMID: 11738281) ; Heart Fail Clin. 2018 Jan;14(1):41-48. (PMID: 29153199) ; Clin Chim Acta. 2015 Mar 30;443:57-70. (PMID: 25269091) ; Prog Cardiovasc Dis. 2018 Nov - Dec;61(5-6):446-455. (PMID: 30408469) ; Dis Markers. 2017;2017:2714095. (PMID: 28566800) ; Heart Fail Clin. 2020 Jan;16(1):99-106. (PMID: 31735319) ; Discoveries (Craiova). 2020 Sep 30;8(3):e115. (PMID: 33102689) ; G Ital Cardiol (Rome). 2018 Nov;19(11 Suppl 1):3S-73S. (PMID: 30520455) ; J Am Coll Cardiol. 2017 Apr 4;69(13):1694-1703. (PMID: 28359515) ; J Cell Mol Med. 2017 Jul;21(7):1292-1299. (PMID: 28121058) ; Int J Gen Med. 2020 Nov 27;13:1297-1304. (PMID: 33273849) ; Hypertension. 2020 Feb;75(2):285-292. (PMID: 31865786) ; N Engl J Med. 1990 May 31;322(22):1561-6. (PMID: 2139921) ; J Am Coll Cardiol. 2019 Oct 29;74(17):2193-2203. (PMID: 31648713) ; Am Heart J. 2007 Feb;153(2):238-44. (PMID: 17239683) ; Circ Res. 1990 May;66(5):1400-12. (PMID: 2335033) ; J Am Coll Cardiol. 2010 Jan 19;55(3):243-50. (PMID: 20117403) ; J Hum Hypertens. 2014 Jul;28(7):432-7. (PMID: 24401951) ; Int J Biochem Cell Biol. 2019 Nov;116:105619. (PMID: 31561019) ; Curr Hypertens Rep. 2020 Feb 3;22(2):11. (PMID: 32016791) ; Clin Chem. 2012 Dec;58(12):1673-81. (PMID: 23065477) ; Card Fail Rev. 2020 Mar 16;6:1-7. (PMID: 32257387) ; J Clin Med. 2019 Feb 22;8(2):. (PMID: 30813357) ; Congenit Heart Dis. 2019 May;14(3):446-453. (PMID: 30650250) ; Ann Noninvasive Electrocardiol. 2019 Jul;24(4):e12635. (PMID: 30719815) ; ESC Heart Fail. 2023 Feb;10(1):303-310. (PMID: 36210061) ; Rev Invest Clin. 2020 Dec 01;:. (PMID: 33262538) ; Ann Noninvasive Electrocardiol. 2021 Nov;26(6):e12863. (PMID: 34114298) ; Am J Cardiol. 2015 Apr 2;115(7 Suppl):3B-7B. (PMID: 25665766) ; Lancet. 2007 Aug 18;370(9587):591-603. (PMID: 17707755) ; Heart. 2015 Sep;101(17):1382-8. (PMID: 26037104) Grant Information: 2019YD065 Yantai Key Research and Development Plan; 2019-0509 Develop Project of Science and Technology in Traditional Chinese Medicine of Shandong Province, China; BY2018KYQD14 Research Plan and Research Start-up Fund of Binzhou Medical University, China; 2020Z449 Jiangsu Provincial Postdoctoral Research Funding Program; QNRC2016382 Jiangsu Provincial Medical Youth Talent; 81900306 National Natural Science Foundation of China Contributed Indexing: Keywords: Essential hypertension (EH); Left ventricular hypertrophy (LVH); Soluble ST2 Substance Nomenclature: 0 (Biomarkers) ; 0 (Interleukin-1 Receptor-Like 1 Protein) Entry Date(s): Date Created: 20221009 Date Completed: 20230127 Latest Revision: 20230201 Update Code: 20240513 PubMed Central ID: PMC9871704

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Expression of soluble ST2 in patients with essential hypertension and its relationship with left ventricular hypertrophy.