High speed homogenization assisted encapsulation of synergistic essential oils formulation: Characterization, in vitro release study, safety profile, and efficacy towards mitigation of aflatoxin B <subscript>1</subscript> induced deterioration in rice samples.

Das, S ; Chaudhari, AK ; et al.

In: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Jg. 169 (2022-11-01), S. 113443

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Application of essential oils to mitigate aflatoxin B 1 (AFB 1 ) contamination in food is a current research hotspot; however, their direct incorporation may cause toxic effects, and changes in food organoleptic properties. This work aimed to synthesize novel synergistic formulation of Pinus roxburghii, Juniperus communis, and Cupressus sempervirens essential oils by mixture design assay (PJC) and encapsulation of PJC formulation into chitosan nanocomposite (Nm-PJC) with an aim to protect stored rice (Oryza sativa L., prime staple food) against fungi and AFB 1 mediated loss of valuable minerals, macronutrients, and fatty acids. Nm-PJC was characterized through DLS, SEM, FTIR, and XRD analyses, along with controlled delivery from chitosan nanobiopolymer. Encapsulation of synergistic formulation into chitosan-nanomatrix improved antifungal (4.0 μL/mL), antiaflatoxigenic (3.5 μL/mL), and antioxidant activities (P < 0.05). Impairment in ergosterol and methylglyoxal biosynthesis along with in-silico-homology-modeling of major components with Ver-1 and Omt-A proteins advocated chemico-molecular interaction responsible for fungal growth inhibition and AFB 1 secretion. In addition, in-situ efficacy against lipid-peroxidation, fatty acid biodeterioration, and preservation of minerals, macronutrients without affecting organoleptic attributes in rice and high mammalian safety profile (9874.23 μL/kg) suggested practical application of synergistic nanoformulation as innovative smart, and green candidate to mitigate AFB 1 contamination, and shelf-life extension of stored food products.

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Titel:	High speed homogenization assisted encapsulation of synergistic essential oils formulation: Characterization, in vitro release study, safety profile, and efficacy towards mitigation of aflatoxin B <subscript>1</subscript> induced deterioration in rice samples.
Autor/in / Beteiligte Person:	Das, S ; Chaudhari, AK ; Singh, VK ; Singh, BK ; Dubey, NK
Zeitschrift:	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Jg. 169 (2022-11-01), S. 113443
Veröffentlichung:	Exeter : Elsevier Science Ltd ; <i>Original Publication</i>: Oxford ; New York : Pergamon Press, c1982-, 2022
Medientyp:	academicJournal
ISSN:	1873-6351 (electronic)
DOI:	10.1016/j.fct.2022.113443
Schlagwort:	Animals Antifungal Agents pharmacology Antioxidants pharmacology Ergosterol pharmacology Fatty Acids metabolism Pyruvaldehyde pharmacology Aflatoxin B1 chemistry Aflatoxin B1 toxicity Chitosan pharmacology Oils, Volatile chemical synthesis Oils, Volatile chemistry Oryza microbiology Oryza toxicity Food Contamination prevention & control Fungi Food Storage methods
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Food Chem Toxicol] 2022 Nov; Vol. 169, pp. 113443. <i>Date of Electronic Publication: </i>2022 Sep 24. MeSH Terms: Aflatoxin B1* / chemistry ; Aflatoxin B1* / toxicity ; Chitosan* / pharmacology ; Oils, Volatile* / chemical synthesis ; Oils, Volatile* / chemistry ; Oryza* / microbiology ; Oryza* / toxicity ; Food Contamination* / prevention & control ; Fungi* ; Food Storage* / methods ; Animals ; Antifungal Agents / pharmacology ; Antioxidants / pharmacology ; Ergosterol / pharmacology ; Fatty Acids / metabolism ; Pyruvaldehyde / pharmacology Contributed Indexing: Keywords: Aflatoxin B(1); Antifungal; Essential oils; Lipid peroxidation; Nanocomposite; Safety Substance Nomenclature: 9N2N2Y55MH (Aflatoxin B1) ; 0 (Antifungal Agents) ; 0 (Antioxidants) ; 9012-76-4 (Chitosan) ; Z30RAY509F (Ergosterol) ; 0 (Fatty Acids) ; 0 (Oils, Volatile) ; 722KLD7415 (Pyruvaldehyde) Entry Date(s): Date Created: 20220927 Date Completed: 20221031 Latest Revision: 20221031 Update Code: 20240513

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