Einzeltreffer — DigiBib

T follicular helper (T FH ) cells are a specialized subset of CD4 T cells that deliver critical help signals to B cells for the production of high-affinity Abs. Understanding the genetic program regulating T FH differentiation is critical if one wants to manipulate T FH cells during vaccination. A large number of transcription factor (TFs) involved in the regulation of T FH differentiation have been characterized. However, there are likely additional unknown TFs required for this process. To identify new TFs, we screened a large short hairpin RNA library targeting 353 TFs in mice using an in vivo RNA interference screen. Yin Yang 1 (YY-1) was identified as a novel positive regulator of T FH differentiation. Ablation of YY-1 severely impaired T FH differentiation following acute viral infection and protein immunization. We found that the zinc fingers of YY-1 are critical to support T FH differentiation. Thus, we discovered a novel TF involved in the regulation of T FH cells.

Titel:	The Transcription Factor YY-1 Is an Essential Regulator of T Follicular Helper Cell Differentiation.
Autor/in / Beteiligte Person:	Bélanger, S ; Haupt, S ; Freeman, BL ; Getzler, AJ ; Diao, H ; Pipkin, ME ; Crotty, S
Zeitschrift:	Journal of immunology (Baltimore, Md. : 1950), Jg. 209 (2022-10-15), Heft 8, S. 1566-1573
Veröffentlichung:	Bethesda, MD : American Association of Immunologists ; <i>Original Publication</i>: Baltimore : Williams & Wilkins, c1950-, 2022
Medientyp:	academicJournal
ISSN:	1550-6606 (electronic)
DOI:	10.4049/jimmunol.2101176
Schlagwort:	Animals Cell Differentiation Lymphocyte Activation Mice RNA, Small Interfering metabolism T Follicular Helper Cells Germinal Center T-Lymphocytes, Helper-Inducer Transcription Factors metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural Language: English [J Immunol] 2022 Oct 15; Vol. 209 (8), pp. 1566-1573. <i>Date of Electronic Publication: </i>2022 Sep 12. MeSH Terms: Germinal Center* ; T-Lymphocytes, Helper-Inducer* ; Transcription Factors / *metabolism ; Animals ; Cell Differentiation ; Lymphocyte Activation ; Mice ; RNA, Small Interfering / metabolism ; T Follicular Helper Cells References: J Immunol. 2016 Mar 15;196(6):2572-82. (PMID: 26843327) ; Nat Immunol. 2015 Sep;16(9):991-9. (PMID: 26214740) ; Cell. 2010 Mar 5;140(5):744-52. (PMID: 20211142) ; J Virol. 1995 Jul;69(7):4323-30. (PMID: 7769693) ; J Exp Med. 2015 Feb 9;212(2):217-33. (PMID: 25646266) ; Immunity. 2009 Sep 18;31(3):457-68. (PMID: 19631565) ; Nat Immunol. 2017 May;18(5):573-582. (PMID: 28288100) ; Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3911-20. (PMID: 27335461) ; J Immunol. 2013 Apr 1;190(7):3049-53. (PMID: 23447690) ; Cell Mol Immunol. 2020 Mar;17(3):247-260. (PMID: 30842630) ; Cell. 2004 Jun 25;117(7):859-72. (PMID: 15210108) ; Immunity. 2017 Sep 19;47(3):481-497.e7. (PMID: 28930660) ; Nat Commun. 2016 Feb 19;7:10789. (PMID: 26892542) ; Cell. 2012 Oct 12;151(2):289-303. (PMID: 23021777) ; J Biol Chem. 1995 Dec 15;270(50):30213-20. (PMID: 8530432) ; Nature. 2014 Mar 27;507(7493):513-8. (PMID: 24463518) ; Immunity. 2014 Oct 16;41(4):529-42. (PMID: 25367570) ; Immunity. 2015 Feb 17;42(2):239-251. (PMID: 25692700) ; Nat Immunol. 2020 Jul;21(7):777-789. (PMID: 32572238) ; Cell Rep. 2015 Sep 29;12(12):2099-110. (PMID: 26365183) ; J Immunol. 2019 Aug 1;203(3):627-638. (PMID: 31227579) ; Front Immunol. 2017 Apr 27;8:480. (PMID: 28496444) ; Science. 2009 Aug 21;325(5943):1001-5. (PMID: 19628815) ; PLoS One. 2016 May 11;11(5):e0155311. (PMID: 27167731) ; Nat Immunol. 2015 Sep;16(9):980-90. (PMID: 26214741) ; Gene. 1994 Dec 15;150(2):259-66. (PMID: 7821790) ; J Immunol. 2016 Sep 1;197(5):1699-707. (PMID: 27448584) ; EMBO J. 2013 Apr 17;32(8):1168-82. (PMID: 23531880) ; Nat Immunol. 2016 Jul;17(7):834-43. (PMID: 27213691) ; Nat Immunol. 2011 Jun;12(6):536-43. (PMID: 21572431) ; J Immunol. 2012 Apr 15;188(8):3734-44. (PMID: 22427637) ; Genes Dev. 2004 Nov 1;18(21):2627-38. (PMID: 15520282) ; Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):276-81. (PMID: 23248301) ; Nature. 2011 Jan 20;469(7330):343-9. (PMID: 21248841) ; Genes Dev. 2007 May 15;21(10):1179-89. (PMID: 17504937) ; Science. 2009 Aug 21;325(5943):1006-10. (PMID: 19608860) ; Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19296-301. (PMID: 17158804) ; J Immunol. 2015 Jun 15;194(12):5599-603. (PMID: 25957170) ; Immunity. 2011 Jun 24;34(6):932-46. (PMID: 21636296) ; Immunity. 2015 Feb 17;42(2):252-264. (PMID: 25692701) ; Eur J Immunol. 1998 Jan;28(1):390-400. (PMID: 9485218) ; J Biol Chem. 2001 Dec 28;276(52):48871-8. (PMID: 11687571) ; Immunity. 2014 Aug 21;41(2):325-38. (PMID: 25148027) ; Cell. 1991 Oct 18;67(2):377-88. (PMID: 1655281) ; Nat Immunol. 2017 Nov;18(11):1238-1248. (PMID: 28892470) ; Nat Immunol. 2009 Feb;10(2):167-75. (PMID: 19098919) ; J Biol Chem. 1997 Jan 17;272(3):1709-17. (PMID: 8999850) ; Cell. 2000 Mar 17;100(6):655-69. (PMID: 10761931) ; Nat Immunol. 2014 Jul;15(7):657-66. (PMID: 24859451) ; Nat Commun. 2018 Dec 21;9(1):5452. (PMID: 30575739) Grant Information: P01 AI145815 United States AI NIAID NIH HHS; R01 AI072543 United States AI NIAID NIH HHS; S10 RR027366 United States RR NCRR NIH HHS; U19 AI109976 United States AI NIAID NIH HHS Substance Nomenclature: 0 (RNA, Small Interfering) ; 0 (Transcription Factors) Entry Date(s): Date Created: 20220912 Date Completed: 20221005 Latest Revision: 20240601 Update Code: 20240601 PubMed Central ID: PMC11139054

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The Transcription Factor YY-1 Is an Essential Regulator of T Follicular Helper Cell Differentiation.