Einzeltreffer — DigiBib

The Essential Tremor Centralized Brain Repository is the largest repository of prospectively collected essential tremor (ET) brains (n = 231). Hence, we are uniquely poised to address several questions: What proportion of ET cases has Lewy pathology (LP)? What is the nature of that pathology and how does it relate to other comorbidities? Each brain had a complete neuropathological assessment, including α-synuclein immunostaining. We created a 10-category classification scheme to fully encapsulate the patterns of LP observed. Four metrics of cerebellar pathology were also quantified. Mean age at death = 89.0 ± 6.4 years. Fifty-eight (25.1%) had LP and 46 (19.9%) had early to late stages of Parkinson disease (PD). LP was very heterogeneous. Of 58 cases with LP, 14 (24.1%) clinically developed possible PD or PD after a latency of 5 or more years. There was a similar degree of cerebellar pathology in ET cases both with and without LP. In summary, 1 in 4 ET cases had LP-a proportion that seems higher than expected based on studies among control populations. Heterogeneous LP likely reflects clinical associations between ET and PD, and ET with Alzheimer disease-type neuropathology. These data further our understanding of ET and its relatedness to other degenerative diseases.

(© The Author(s) 2022. Published by Oxford University Press on behalf of American Association of Neuropathologists, Inc. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

Titel:	Characterizing Lewy Pathology in 231 Essential Tremor Brains From the Essential Tremor Centralized Brain Repository.
Autor/in / Beteiligte Person:	Louis, ED ; Iglesias-Hernandez, D ; Hernandez, NC ; Flowers, X ; Kuo, SH ; Vonsattel, JPG ; Faust, PL
Zeitschrift:	Journal of neuropathology and experimental neurology, Jg. 81 (2022-09-19), Heft 10, S. 796-806
Veröffentlichung:	2016- : Oxford, England : Oxford University Press ; <i>Original Publication</i>: Lawrence, Ks : Association of the journal of neuropathology and experimental neurology, 2022
Medientyp:	academicJournal
ISSN:	1554-6578 (electronic)
DOI:	10.1093/jnen/nlac068
Schlagwort:	Brain pathology Humans Lewy Bodies pathology alpha-Synuclein Essential Tremor pathology Parkinson Disease pathology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural Language: English [J Neuropathol Exp Neurol] 2022 Sep 19; Vol. 81 (10), pp. 796-806. MeSH Terms: Essential Tremor* / pathology ; Parkinson Disease* / pathology ; Brain / pathology ; Humans ; Lewy Bodies / pathology ; alpha-Synuclein Comments: Comment in: J Neuropathol Exp Neurol. 2023 Apr 20;82(5):454-455. (PMID: 36943259) ; Comment in: J Neuropathol Exp Neurol. 2023 Apr 20;82(5):452-453. (PMID: 36943272) References: Nat Rev Neurol. 2020 Feb;16(2):69-83. (PMID: 31959938) ; Mov Disord. 2016 Mar;31(3):393-401. (PMID: 26861543) ; Acta Neuropathol. 2008 Sep;116(3):269-75. (PMID: 18553090) ; Acta Neuropathol. 2014 Dec;128(6):755-66. (PMID: 25348064) ; J Neuropathol Exp Neurol. 2003 Nov;62(11):1087-95. (PMID: 14656067) ; Acta Neuropathol. 2012 Jan;123(1):1-11. (PMID: 22101365) ; Neuroepidemiology. 1997;16(3):124-33. (PMID: 9159767) ; J Neuropathol Exp Neurol. 2009 Jul;68(7):816-22. (PMID: 19535990) ; Mov Disord. 2008 May 15;23(7):993-997. (PMID: 18383536) ; Neurology. 2004 Mar 9;62(5):734-41. (PMID: 15007123) ; Brain Pathol. 2000 Jul;10(3):378-84. (PMID: 10885656) ; Eur J Neurol. 2010 Jun 1;17(6):871-8. (PMID: 20236304) ; Brain. 2007 Dec;130(Pt 12):3297-307. (PMID: 18025031) ; Neurology. 2006 May 23;66(10):1500-5. (PMID: 16717208) ; Mov Disord. 2007 Aug 15;22(11):1607-14. (PMID: 17546668) ; Brain. 2013 Oct;136(Pt 10):3051-61. (PMID: 24030953) ; Neuropathol Appl Neurobiol. 2006 Jun;32(3):284-95. (PMID: 16640647) ; Neurobiol Aging. 1997 Jul-Aug;18(4 Suppl):S91-4. (PMID: 9330994) ; Acta Neuropathol. 1991;82(4):239-59. (PMID: 1759558) ; J Alzheimers Dis. 2009;18(3):713-25. (PMID: 19661625) ; J Neurol Neurosurg Psychiatry. 2011 Mar;82(3):261-5. (PMID: 20802027) ; Mov Disord. 2014 Nov;29(13):1583-90. (PMID: 24976103) ; Clin Neuropathol. 2012 Mar-Apr;31(2):87-98. (PMID: 22385790) ; J Neuropathol Exp Neurol. 2004 Jul;63(7):742-9. (PMID: 15290899) ; Neurology. 2005 Aug 9;65(3):391-6. (PMID: 16087903) ; Brain. 2019 Jun 1;142(6):1503-1527. (PMID: 31039256) ; Brain. 2014 Dec;137(Pt 12):3142-8. (PMID: 25367027) ; Neurology. 2007 Nov 20;69(21):1982-9. (PMID: 18025392) ; Parkinsonism Relat Disord. 2018 Jan;46 Suppl 1:S101-S104. (PMID: 28729090) ; Neurology. 2009 Aug 25;73(8):621-5. (PMID: 19704081) ; Neuroepidemiology. 2011;37(1):1-10. (PMID: 21757958) ; Neurology. 2008 Mar 25;70(13):1042-8. (PMID: 18362284) ; Neurobiol Aging. 2003 Mar-Apr;24(2):197-211. (PMID: 12498954) ; Mov Disord. 2007 Aug 15;22(11):1573-80. (PMID: 17516478) ; Brain. 2012 Jan;135(Pt 1):105-16. (PMID: 22120148) ; Mov Disord. 2009 Mar 15;24(4):626-7. (PMID: 19185016) ; J Clin Neurosci. 2012 Jun;19(6):920-1. (PMID: 22321358) ; Mov Disord. 2009 Aug 15;24(11):1662-8. (PMID: 19514058) ; J Neurol Sci. 2016 Jul 15;366:47-51. (PMID: 27288775) ; Neurobiol Aging. 2011 May;32(5):857-63. (PMID: 19560232) ; Acta Neuropathol. 2019 Nov;138(5):859-876. (PMID: 31317229) ; Neurology. 2006 Jun 13;66(11):1756-9. (PMID: 16769958) ; Neuropathol Appl Neurobiol. 2001 Aug;27(4):314-25. (PMID: 11532162) ; J Neurol Neurosurg Psychiatry. 2009 Apr;80(4):423-5. (PMID: 19289477) ; Parkinsonism Relat Disord. 2021 Oct;91:42-47. (PMID: 34482193) ; Cerebellum Ataxias. 2020 Aug 14;7:12. (PMID: 32922824) ; Neurology. 2008 Apr 15;70(16 Pt 2):1452-5. (PMID: 18413570) ; Mov Disord. 2011 Feb 15;26(3):372-7. (PMID: 21284040) ; J Neuropathol Exp Neurol. 2014 Mar;73(3):244-52. (PMID: 24487796) ; J Neuropathol Exp Neurol. 2021 Sep 27;80(9):835-843. (PMID: 34363663) ; Acta Neuropathol. 2003 Oct;106(4):374-82. (PMID: 12904992) ; Brain. 2014 Dec;137(Pt 12):3149-59. (PMID: 25273997) ; Parkinsonism Relat Disord. 2016 Jan;22 Suppl 1:S162-5. (PMID: 26522219) ; J Neuropathol Exp Neurol. 2011 Nov;70(11):960-9. (PMID: 22002422) ; Acta Neuropathol. 2008 Apr;115(4):399-407. (PMID: 18297293) ; Neurology. 2005 Dec 27;65(12):1863-72. (PMID: 16237129) ; Tremor Other Hyperkinet Mov (N Y). 2021 Jul 09;11:28. (PMID: 34277141) ; J Neuropathol Exp Neurol. 2003 Apr;62(4):363-7. (PMID: 12722828) ; Arch Neurol. 2005 Jun;62(6):1004-7. (PMID: 15956174) ; J Neuropathol Exp Neurol. 2019 Jan 1;78(1):31-37. (PMID: 30476290) ; Mov Disord. 2014 Nov;29(13):1637-47. (PMID: 24531928) ; J Neuropathol Exp Neurol. 2010 Mar;69(3):262-71. (PMID: 20142764) ; Acta Neuropathol. 2022 Jul;144(1):45-57. (PMID: 35551470) ; Parkinsonism Relat Disord. 2014 Jun;20(6):655-8. (PMID: 24679899) Grant Information: R01 NS088257 United States NS NINDS NIH HHS; R01 NS117745 United States NS NINDS NIH HHS; R01 GM086736 United States GM NIGMS NIH HHS Contributed Indexing: Keywords: Alzheimer disease; Brain repository; Cerebellar degeneration; Essential tremor; Lewy pathology; Neurodegeneration; Parkinson disease Substance Nomenclature: 0 (alpha-Synuclein) Entry Date(s): Date Created: 20220811 Date Completed: 20220923 Latest Revision: 20231201 Update Code: 20240513 PubMed Central ID: PMC9487643

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Characterizing Lewy Pathology in 231 Essential Tremor Brains From the Essential Tremor Centralized Brain Repository.