Evaluation of trace elements in essential thrombocytosis and reactive thrombocytosis.

Tekin, TO ; Karis, D ; et al.

In: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), Jg. 73 (2022-09-01), S. 127034

academicJournal

Wie komme ich dran?

Background: Trace elements (TE) are vital for cellular mechanisms at biological, chemical and molecular levels. The effects of TE in diagnosis, progression and treatment of essential thrombocytosis (ET), which is one of the chronic myeloproliferative neoplasms is a rare clonal stem cell disease characterized by increased thrombocyte numbers with impaired function, have not been elucidated in detail yet. The aim of the present study was to investigate the effects of TE alterations in an ET model and the efficacy of TE in ET treatment protocol by means of a vast number of TE.

Methods: Study groups were categorized as patients with ET diagnosis (ET group, n:30), patients with reactive thrombocytosis secondary to iron deficiency anemia (IDA-RT) (IDA-RT group, n:30) and healthy controls (HC group, n:30). Serum levels of copper (Cu), iron (Fe), cobalt (Co), chromium (Cr), aluminum (Al), silicon (Si), nickel (Ni), zinc (Zn), selenium (Se), manganese (Mn), boron (B) and magnesium (Mg) were analyzed utilizing inductively coupled plasma-optical emission spectrophotometer instrument (ICP-OES). Statistical analysis was evaluated using SPSS 23.0.

Results: ET group had statistically higher serum levels of Co and Mg (p < 0.05), Ni and Mn (p < 0.001), and lower Si (p < 0.05) than IDA-RT group. ET group had statistically higher serum levels of Co and Mn (p < 0.05), and Ni (p < 0.001), and lower Al, Si and Se (p < 0.001) than HC group. Serum levels of Fe, Al and Se (p < 0.001), and Mg (p < 0.01), and Zn (p < 0.05) in IDA-RT group were significantly lower than HC group.

Conclusion: This novel study pointed out that alterations of many serum TE by means of both increment or decrement might have close relationship with mechanisms and complications of ET onset and follow-up. We consider that further research of TE would elucidate ethiopathogenesis and prognosis of ET. Thus, analysis of serum trace elements in essential thrombocytosis patients may be an important protocol by means of diagnosis, treatment and follow-up intervals.

Titel:	Evaluation of trace elements in essential thrombocytosis and reactive thrombocytosis.
Autor/in / Beteiligte Person:	Tekin, TO ; Karis, D ; Ates Alkan, F ; Cetin, G ; Ercan, AM
Zeitschrift:	Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), Jg. 73 (2022-09-01), S. 127034
Veröffentlichung:	Stuttgart : Gustav Fisher ; <i>Original Publication</i>: Stuttgart ; New York : Gustav Fischer, c1995-, 2022
Medientyp:	academicJournal
ISSN:	1878-3252 (electronic)
DOI:	10.1016/j.jtemb.2022.127034
Schlagwort:	Cobalt Copper Humans Magnesium Manganese Nickel Zinc Selenium Thrombocytosis Trace Elements analysis
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [J Trace Elem Med Biol] 2022 Sep; Vol. 73, pp. 127034. <i>Date of Electronic Publication: </i>2022 Jul 08. MeSH Terms: Selenium* ; Thrombocytosis* ; Trace Elements* / analysis ; Cobalt ; Copper ; Humans ; Magnesium ; Manganese ; Nickel ; Zinc Contributed Indexing: Keywords: Essential thrombocytosis; Reactive thrombocytosis; Trace elements Substance Nomenclature: 0 (Trace Elements) ; 3G0H8C9362 (Cobalt) ; 42Z2K6ZL8P (Manganese) ; 789U1901C5 (Copper) ; 7OV03QG267 (Nickel) ; H6241UJ22B (Selenium) ; I38ZP9992A (Magnesium) ; J41CSQ7QDS (Zinc) Entry Date(s): Date Created: 20220715 Date Completed: 20220808 Latest Revision: 20220808 Update Code: 20231215

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.