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Background: Previous studies on the relationship between ACE I/D, ACE2 G8790A and CYP11B2-344T/C gene polymorphisms and essential hypertension (EH) were inconsistent. Moreover, few studies have reported the combined effect of these gene polymorphisms and noise exposure on EH. The purpose of this study was to explore the combined and separate effects of ACE I/D, ACE2 G8790A and CYP11B2-344T/C gene polymorphisms and noise on EH among steelworkers.

Methods: A case-control study was conducted on 725 male workers between March 2014 and July 2014 in the Tangsteel Company, China. The noise exposure of the workers were measured. Logistic regression and crossover analysis were used to analyse the effects of the interactions on the EH among steelworkers. GMDR was used to determine the best combination model of gene-noise interactions.

Results: Multivariate logistic regression showed that noise exposure increased the odds of EH, and the OR is 1.52 (95% CI 1.04-2.22). The risk of having EH for ACE I/D DD genotype carriers was 1.99 times that for II genotype carriers (95% CI 1.14-3.51). There was a negative additive interaction between ACE2 G8790A and CYP11B2-344T/C on EH (U3 = - 2.221, P = 0.026, and S = 0.128) and a positive multiplicative interaction between ACE I/D and CYP11B2-344T/C on essential hypertension (P = 0.041). In addition, there was no significant gene-noise interaction model through the GMDR method after adjusting the confounders.

Conclusions: The ACE DD genotype may make men susceptible to EH. Simultaneously carrying the DD genotype of ACE I/D and the TC genotype of CYP11B2-344T/C increased the risk of EH.

Titel:	Effect of ACE, ACE2 and CYP11B2 gene polymorphisms and noise on essential hypertension among steelworkers in China: a case-control study.
Autor/in / Beteiligte Person:	Zhang, X ; Wang, Y ; Zheng, Y ; Yuan, J ; Tong, J ; Xu, J ; Li, Q ; Li, P ; Jiang, S ; Wang, Z ; Chai, F ; Li, X
Zeitschrift:	BMC medical genomics, Jg. 15 (2022-02-08), Heft 1, S. 22
Veröffentlichung:	London : BioMed Central, 2022
Medientyp:	academicJournal
ISSN:	1755-8794 (electronic)
DOI:	10.1186/s12920-022-01177-0
Schlagwort:	Case-Control Studies China Essential Hypertension genetics Gene Frequency Genotype Humans Male Polymorphism, Genetic Angiotensin-Converting Enzyme 2 genetics Cytochrome P-450 CYP11B2 genetics Hypertension genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [BMC Med Genomics] 2022 Feb 08; Vol. 15 (1), pp. 22. <i>Date of Electronic Publication: </i>2022 Feb 08. MeSH Terms: Cytochrome P-450 CYP11B2* / genetics ; Hypertension* / genetics ; Angiotensin-Converting Enzyme 2 / *genetics ; Case-Control Studies ; China ; Essential Hypertension / genetics ; Gene Frequency ; Genotype ; Humans ; Male ; Polymorphism, Genetic References: Indian J Med Res. 2010 Oct;132:379-85. (PMID: 20966514) ; Heart Asia. 2016 May 19;8(1):83-9. (PMID: 27326240) ; J Renin Angiotensin Aldosterone Syst. 2015 Dec;16(4):975-81. (PMID: 26283679) ; Clin Exp Hypertens. 2016;38(1):63-70. (PMID: 26305278) ; Occup Environ Med. 2012 Apr;69(4):236-42. (PMID: 22107792) ; Int J Clin Exp Med. 2015 Jan 15;8(1):1173-7. (PMID: 25785110) ; Eur J Clin Invest. 2018 Jan;48(1):. (PMID: 29178542) ; Curr Atheroscler Rep. 2010 May;12(3):167-73. (PMID: 20425255) ; JAMA. 2003 May 21;289(19):2560-72. (PMID: 12748199) ; Front Physiol. 2012 Sep 12;3:364. (PMID: 22988445) ; Hypertens Res. 2001 Mar;24(2):105-9. (PMID: 11325068) ; Hypertension. 1995 May;25(5):940-9. (PMID: 7737731) ; Clin Exp Hypertens. 2017;39(5):448-453. (PMID: 28534704) ; Am J Hypertens. 2010 Mar;23(3):237-42. (PMID: 19959996) ; Clin Exp Hypertens. 2016;38(8):659-665. (PMID: 27935319) ; Int J Occup Environ Health. 2014 Jul-Sep;20(3):194-206. (PMID: 25000107) ; Medicine (Baltimore). 2018 Jul;97(30):e11720. (PMID: 30045338) ; Endocrinology. 2011 Apr;152(4):1218-21. (PMID: 21248141) ; Braz J Med Biol Res. 2007 Mar;40(3):309-16. (PMID: 17334527) ; Nature. 1991 Oct 10;353(6344):521-9. (PMID: 1656270) ; Exp Mol Med. 2003 Dec 31;35(6):545-9. (PMID: 14749533) ; Curr Opin Pharmacol. 2011 Apr;11(2):117-23. (PMID: 21269877) ; Lancet. 2017 Dec 9;390(10112):2549-2558. (PMID: 29102084) Contributed Indexing: Keywords: Essential hypertension; GMDR; Gene polymorphism; Interaction; Noise Substance Nomenclature: EC 1.14.15.4 (Cytochrome P-450 CYP11B2) ; EC 3.4.17.23 (ACE2 protein, human) ; EC 3.4.17.23 (Angiotensin-Converting Enzyme 2) Entry Date(s): Date Created: 20220208 Date Completed: 20220407 Latest Revision: 20220531 Update Code: 20240513 PubMed Central ID: PMC8822663

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Effect of ACE, ACE2 and CYP11B2 gene polymorphisms and noise on essential hypertension among steelworkers in China: a case-control study.