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Background: The limited ovicidal activity of currently available acaricides is a significant obstacle to efficacious scabies treatment. Several essential oils or their respective components have proved to be active against the eggs of arthropods, mainly lice and ticks. Information on the activity of these oils and/or components against the eggs of mites remains very limited. The aim of this study was to assess the activity of six terpenes (carvacrol, eugenol, geraniol, citral, terpinen-4-ol and linalool) commonly found in essential oils against the eggs of Sarcoptes scabiei.

Methods: Sarcoptes eggs were exposed to paraffin oil containing 1, 2.5, or 5% of each terpene tested. After a 12-h exposure period, the eggs were washed and placed in paraffin oil for hatching. Embryonic development following treatment was assessed every day to determine the stage of developmental arrest.

Results: The median effective concentration to obtain 50% egg mortality (EC 50 ) was 0.5, 0.9, 2.0, 4.8, 5.1 and 9.8% for carvacrol, eugenol, geraniol, citral, terpinen-4-ol and linalool, respectively. The microscopic images of eggs after each treatment indicated that these six terpenes may act by penetrating through the aeropyles on the egg surface.

Conclusions: In conclusion, carvacrol, eugenol and geraniol possess significant ovicidal activities, which should be considered as promising ovicidal agents for the treatment of scabies.

Titel:	Activity of terpenes derived from essential oils against Sarcoptes scabiei eggs.
Autor/in / Beteiligte Person:	Li, M ; Liu, S ; Yin, Z ; Bernigaud, C ; Guillot, J ; Fang, F
Zeitschrift:	Parasites & vectors, Jg. 14 (2021-12-09), Heft 1, S. 600
Veröffentlichung:	London : BioMed Central, 2021
Medientyp:	academicJournal
ISSN:	1756-3305 (electronic)
DOI:	10.1186/s13071-021-05094-6
Schlagwort:	Acyclic Monoterpenes pharmacology Animals Cymenes pharmacology Eugenol pharmacology Female Ovum drug effects Scabies parasitology Acaricides pharmacology Oils, Volatile chemistry Plant Oils chemistry Sarcoptes scabiei drug effects Scabies drug therapy Terpenes pharmacology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Parasit Vectors] 2021 Dec 09; Vol. 14 (1), pp. 600. <i>Date of Electronic Publication: </i>2021 Dec 09. MeSH Terms: Acaricides / pharmacology ; Oils, Volatile / chemistry ; Plant Oils / chemistry ; Sarcoptes scabiei / drug effects ; Scabies / drug therapy ; Terpenes / pharmacology ; Acyclic Monoterpenes / pharmacology ; Animals ; Cymenes / pharmacology ; Eugenol / pharmacology ; Female ; Ovum / drug effects ; Scabies / parasitology References: Chandler DJ, Fuller LC. A review of scabies: an infestation more than skin deep. Dermatology. 2019;235:79–90. (PMID: 10.1159/000495290) ; Bernigaud C, Samarawickrama G, Jones MK, Gasser RB, Fischer K. The challenge of developing a single-dose treatment for scabies. Trends Parasitol. 2019;35(11):931–43. (PMID: 10.1016/j.pt.2019.08.002) ; Bernigaud C, Fernando DD, Lu H, Taylor S, Hartel G, Guillot J, et al. 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(PMID: 10.1146/annurev.en.34.010189.001035) ; Tisserand R, Young R. Essential oil safety. Amsterdam: Elsevier; 2014. https://linkinghub.elsevier.com/retrieve/pii/B9780443062414000011 . Grant Information: 31902293 national natural science foundation of china Contributed Indexing: Keywords: Essential oil; Ovicidal activity; Sarcoptes scabiei; Scabies; Terpenes Substance Nomenclature: 0 (Acaricides) ; 0 (Acyclic Monoterpenes) ; 0 (Cymenes) ; 0 (Oils, Volatile) ; 0 (Plant Oils) ; 0 (Terpenes) ; 3T8H1794QW (Eugenol) ; 562-74-3 (terpinenol-4) ; 9B1J4V995Q (carvacrol) ; D81QY6I88E (linalool) ; L837108USY (geraniol) ; T7EU0O9VPP (citral) Entry Date(s): Date Created: 20211210 Date Completed: 20220117 Latest Revision: 20220125 Update Code: 20231215 PubMed Central ID: PMC8656058

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Activity of terpenes derived from essential oils against Sarcoptes scabiei eggs.