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Hydroxychloroquine is an antimalarial drug with immunomodulatory, anti-inflammatory, antibacterial, and antiviral properties. It has a good safety profile, can be used in children and in pregnant and breastfeeding women, and does not suppress the immune system. Regular screening for retinopathy, one of the drug's most feared adverse effects, is necessary. Hydroxychloroquine is a widely used, essential drug in dermatology. Clinical response rates are good in lupus erythematous, where it is a first-line therapy, as well in numerous autoimmune/inflammatory diseases, including lichen planus, polymorphic light eruption, porphyria cutanea tarda, granuloma annulare, and sarcoidosis. In 2020, it was widely prescribed both to prevent and to treat COVID-19 caused by SARS-CoV-2. Its increased use led to serious supply shortages and in some cases stocks were entirely depleted. Recent meta-analyses have concluded that hydroxychloroquine is ineffective against COVID-19 and have advised against its use.

Titel:	[Hydroxychloroquine: An Essential Drug in Dermatology and Its Controversial Use in COVID-19].
Autor/in / Beteiligte Person:	Morgado-Carrasco, D ; Ibaceta-Ayala, J ; Piquero-Casals, J
Zeitschrift:	Actas dermo-sifiliograficas, Jg. 113 (2022-02-01), Heft 2, S. 166-175
Veröffentlichung:	<2009- > : Madrid : Elsevier España ; <i>Original Publication</i>: Madrid, Academia Española de Dermatología y Sifilografía., 2022
Medientyp:	academicJournal
ISSN:	1578-2190 (electronic)
DOI:	10.1016/j.ad.2021.07.005
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: Spanish; Castilian Transliterated Title: La hidroxicloroquina como fármaco fundamental en dermatología y su papel controvertido en la COVID-19. Publication Type: English Abstract; Journal Article Language: Spanish; Castilian [Actas Dermosifiliogr] 2022 Feb; Vol. 113 (2), pp. 166-175. <i>Date of Electronic Publication: </i>2021 Aug 02. References: Semin Arthritis Rheum. 1988 May;17(4):221-31. (PMID: 3232080) ; Clin Gastroenterol Hepatol. 2012 Dec;10(12):1402-9. (PMID: 22985607) ; PLoS One. 2022 Aug 29;17(8):e0273389. (PMID: 36037216) ; JAMA Ophthalmol. 2014 Dec;132(12):1453-60. (PMID: 25275721) ; J Am Acad Dermatol. 2010 Mar;62(3):387-92. (PMID: 20061052) ; Br J Dermatol. 1996 Feb;134(2):373. (PMID: 8746362) ; Br J Dermatol. 1987 Mar;116(3):379-86. (PMID: 3552020) ; J Am Acad Dermatol. 1993 Apr;28(4):609-12. (PMID: 8463463) ; Arthritis Care Res (Hoboken). 2018 Mar;70(3):481-485. (PMID: 28556555) ; J Am Acad Dermatol. 2019 Jun;80(6):1658-1663. (PMID: 30703458) ; Australas J Dermatol. 2012 Feb;53(1):e10-3. (PMID: 22309344) ; Pediatr Dermatol. 2018 May;35(3):361-365. (PMID: 29575039) ; Indian J Med Microbiol. 2021 Apr;39(2):159-170. (PMID: 33781656) ; J Invest Dermatol. 2021 Aug;141(8):1906-1914.e2. (PMID: 33675790) ; Ann Rheum Dis. 2021 Feb;80(2):1-2. (PMID: 32586918) ; J Am Acad Dermatol. 2021 Oct;85(4):1046-1047. (PMID: 33607179) ; Cutis. 2008 Apr;81(4):351-4. (PMID: 18491485) ; J Rheumatol. 2020 Jun 1;47(6):787-790. (PMID: 32269064) ; J Am Acad Dermatol. 2021 Feb;84(2):543-545. (PMID: 32439466) ; J Am Acad Dermatol. 1990 Sep;23(3 Pt 1):487-9. (PMID: 2212149) ; Dermatology. 2016;232(1):86-90. (PMID: 26445088) ; Photodermatol. 1984 Dec;1(6):286-92. (PMID: 6398430) ; Arch Dermatol. 2008 Jan;144(1):118-9. (PMID: 18209184) ; J Am Acad Dermatol. 2017 Jun;76(6):1176-1182. (PMID: 28318681) ; Dev World Bioeth. 2021 Dec;21(4):193-200. (PMID: 32844516) ; Dermatol Ther. 2021 May;34(3):e14903. (PMID: 33605044) ; J Am Acad Dermatol. 2019 Aug;81(2):568-580. (PMID: 30953702) ; J Dermatol. 2019 Apr;46(4):285-289. (PMID: 30719729) ; Am J Trop Med Hyg. 2020 Jun;102(6):1184-1188. (PMID: 32323646) ; Int J Womens Dermatol. 2017 Jun 13;3(4):189-194. (PMID: 29234712) ; Australas J Dermatol. 2020 May;61(2):e150-e157. (PMID: 31612996) ; J Am Acad Dermatol. 2017 Apr;76(4):765-767. (PMID: 28325398) ; J Allergy Clin Immunol. 2019 Feb;143(2):458-466. (PMID: 30268388) ; Dermatology. 2005;211(2):167-8. (PMID: 16088169) ; Dermatol Ther. 2020 Jul;33(4):e13524. (PMID: 32383251) ; Arthritis Rheumatol. 2015 Feb;67(2):527-34. (PMID: 25385679) ; Dermatol Ther. 2017 May;30(3):. (PMID: 28168851) ; Indian Dermatol Online J. 2020 May 10;11(3):453-464. (PMID: 32695719) ; J Am Acad Dermatol. 2020 Mar;82(3):709-722. (PMID: 31306730) ; Cochrane Database Syst Rev. 2021 Feb 12;2:CD013587. (PMID: 33624299) ; Eur Ann Allergy Clin Immunol. 2017 Sep;49(5):220-224. (PMID: 28884989) ; Br J Dermatol. 2010 Dec;163(6):1296-300. (PMID: 20698851) ; Int J Dermatol. 2010 Apr;49(4):467-9. (PMID: 20465710) ; Actas Dermosifiliogr (Engl Ed). 2021 Feb;112(2):118-126. (PMID: 33045209) ; Cutis. 2017 Nov;100(5):312-316. (PMID: 29232421) ; N Engl J Med. 2021 Feb 4;384(5):417-427. (PMID: 33289973) ; Br J Dermatol. 2021 Jul;185(1):201-203. (PMID: 33548058) ; Dermatol Ther. 2020 Sep;33(5):e13829. (PMID: 32542964) ; Indian J Dermatol Venereol Leprol. 2008 Jan-Feb;74(1):18-22. (PMID: 18187817) ; J Am Acad Dermatol. 2014 Apr;70(4):670-678. (PMID: 24508293) ; Int J Prev Med. 2017 May 25;8:37. (PMID: 28584619) ; J Am Acad Dermatol. 1994 Mar;30(3):510. (PMID: 8113476) ; Australas J Dermatol. 2019 May;60(2):e109-e112. (PMID: 30411331) ; JAMA Dermatol. 2019 Apr 1;155(4):494-496. (PMID: 30673076) Contributed Indexing: Keywords: COVID-19; Dermatology; Hydroxychloroquine; Lichen planus; Lupus erythematosus; Supply shortages Entry Date(s): Date Created: 20210809 Latest Revision: 20231107 Update Code: 20240513 PubMed Central ID: PMC8326180

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[Hydroxychloroquine: An Essential Drug in Dermatology and Its Controversial Use in COVID-19].