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Eight essential oils (EOs) from selected medicinal plants have been tested for their activity against Phytomonas davidi, a plant trypanosomal parasite. In the present research, the EOs have been tested on promastigote forms of P. davidi ATCC ® 30287™ strain, along with their major components, both separately and in binary combinations, using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction assay. The EOs with the highest antipromastigote activity were from Origanum virens and Salvia lavandulifolia. Thymol and β-pinene were the most active pure compounds. The study of the activity of the pure compounds in combination indicated the existence of antagonistic and synergistic effects depending on the concentration tested. In general, the combinations at low concentrations favored the activity.

Titel:	Biological Evaluation of Essential Oils from Selected Medicinal Plants and Their Main Components against Phytomonas davidi (Kinetoplastea: Trypanosomatidae).
Autor/in / Beteiligte Person:	Guzmán, M ; González-Coloma, A ; Fe Andrés, M ; Navarro-Rocha, J ; Martínez-Díaz, RA
Zeitschrift:	Chemistry & biodiversity, Jg. 17 (2020-10-01), Heft 10, S. e2000521
Veröffentlichung:	Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004-, 2020
Medientyp:	academicJournal
ISSN:	1612-1880 (electronic)
DOI:	10.1002/cbdv.202000521
Schlagwort:	Antiprotozoal Agents chemistry Antiprotozoal Agents isolation & purification Bicyclic Monoterpenes chemistry Bicyclic Monoterpenes isolation & purification Oils, Volatile chemistry Oils, Volatile isolation & purification Origanum chemistry Parasitic Sensitivity Tests Salvia chemistry Thymol chemistry Thymol isolation & purification Antiprotozoal Agents pharmacology Bicyclic Monoterpenes pharmacology Oils, Volatile pharmacology Plants, Medicinal chemistry Thymol pharmacology Trypanosomatina drug effects
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Chem Biodivers] 2020 Oct; Vol. 17 (10), pp. e2000521. <i>Date of Electronic Publication: </i>2020 Sep 18. MeSH Terms: Antiprotozoal Agents / pharmacology ; Bicyclic Monoterpenes / pharmacology ; Oils, Volatile / pharmacology ; Plants, Medicinal / chemistry ; Thymol / pharmacology ; Trypanosomatina / drug effects ; Antiprotozoal Agents / chemistry ; Antiprotozoal Agents / isolation & purification ; Bicyclic Monoterpenes / chemistry ; Bicyclic Monoterpenes / isolation & purification ; Oils, Volatile / chemistry ; Oils, Volatile / isolation & purification ; Origanum / chemistry ; Parasitic Sensitivity Tests ; Salvia / chemistry ; Thymol / chemistry ; Thymol / isolation & purification References: K. Stuart, R. Brun, S. Croft, A. Fairlamb, R. E. Gürtler, J. McKerrow, S. Reed, R. Tarleton, ‘Kinetoplastids: related protozoan pathogens, different diseases’, J. Clin. 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Grant Information: CTQ2015-64049-C3-1-R (MINECO/FEDER) Contributed Indexing: Keywords: Lamiaceae; antiprotozoal activity; compound interactions; monoterpenes; natural products Substance Nomenclature: 0 (Antiprotozoal Agents) ; 0 (Bicyclic Monoterpenes) ; 0 (Oils, Volatile) ; 3J50XA376E (Thymol) ; 4MS8VHZ1HJ (beta-pinene) Entry Date(s): Date Created: 20200918 Date Completed: 20210517 Latest Revision: 20210517 Update Code: 20240513

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Biological Evaluation of Essential Oils from Selected Medicinal Plants and Their Main Components against Phytomonas davidi (Kinetoplastea: Trypanosomatidae).