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The objective of this study was to determine the chemical profile and to evaluate the antibacterial activity of the essential oils of Piper species and modulation of the antibiotic activity, using the microdilution method to determine the minimum inhibitory concentration. The chemical components were characterized by gas chromatography coupled to mass spectrometry, which revealed β-copaen-4-α-ol (31.38%), spathulenol (25.92%), and germacrene B (21.53%) as major constituents of the essential oils of Piper arboreum, Piper aduncum , and Piper gaudichaudianum , respectively. The essential oils analyzed in this study did not present a clinically relevant activity against standard and multiresistant Escherichia coli . However, in the case of multiresistant Staphylococcus aureus , there was a significant activity, corroborating with reports in the literature, where Gram-positive bacteria are more susceptible to antimicrobial activity. The essential oils modulated the effect of the antibiotics norfloxacin and gentamicin, having on the latter greater modulating effect; however, for erythromycin, no statistically significant effect was observed. In conclusion, the results obtained in this study demonstrated that the essential oils of the analyzed Piper species present an inhibitory effect against S. aureus and modulate antibiotic activity, most of which presents synergistic activity.

Titel:	Gas chromatography coupled to mass spectrometry (GC-MS) characterization and evaluation of antibacterial bioactivities of the essential oils from Piper arboreum Aubl., Piper aduncum L. e Piper gaudichaudianum Kunth.
Autor/in / Beteiligte Person:	da Silva ACA ; Matias, EFF ; Rocha, JE ; Araújo, ACJ ; de Freitas TS ; Campina, FF ; Costa, MDS ; Silva, LE ; Amaral, WD ; Maia, BHLNS ; Ferriani, AP ; Bezerra, CF ; Iriti, M ; Coutinho, HDM
Zeitschrift:	Zeitschrift fur Naturforschung. C, Journal of biosciences, Jg. 76 (2020-07-16), Heft 1-2, S. 35-42
Veröffentlichung:	Berlin : De Gruyter ; <i>Original Publication</i>: Tübingen : Verlag der Zeitschrift für Naturforschung, 1986-, 2020
Medientyp:	academicJournal
ISSN:	1865-7125 (electronic)
DOI:	10.1515/znc-2020-0045
Schlagwort:	Anti-Bacterial Agents pharmacology Escherichia coli drug effects Oils, Volatile pharmacology Plant Oils pharmacology Sesquiterpenes analysis Sesquiterpenes, Germacrane analysis Staphylococcus aureus drug effects Anti-Bacterial Agents chemistry Oils, Volatile chemistry Piper chemistry Plant Oils chemistry
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Z Naturforsch C J Biosci] 2020 Jul 16; Vol. 76 (1-2), pp. 35-42. <i>Date of Electronic Publication: </i>2020 Jul 16 (<i>Print Publication: </i>2021). MeSH Terms: Anti-Bacterial Agents / chemistry ; Oils, Volatile / chemistry ; Piper / chemistry ; Plant Oils / chemistry ; Anti-Bacterial Agents / pharmacology ; Escherichia coli / drug effects ; Oils, Volatile / pharmacology ; Plant Oils / pharmacology ; Sesquiterpenes / analysis ; Sesquiterpenes, Germacrane / analysis ; Staphylococcus aureus / drug effects References: Kamiloglu, S, Capanoglu, E, Yilmaz, O, Duran, AF, Boyacioglu, D. Investigating the antioxidant potential of Turkish herbs and spices. Qual Assur Saf Crop Food 2014;6:151–8. https://doi.org/10.3920/qas2012.0237. ; Karadeniz, A, Cinbilgel, I, Gun, SS, Cetin, A. Antioxidant activity of some Turkish medicinal plants. Nat Prod Res 2015;29:2308–12. https://doi.org/10.1080/14786419.2015.1005618. ; Zheng, W, Wang, SY. Antioxidant activity and phenolic compounds in selected herbs. J Agric Food Chem 2001;49:5165–70. https://doi.org/10.1021/jf010697n. ; Sala, A, Recio, MDC, Giner, RM, Máñez, S, Tournier, H, Schinella, G, et al. Anti-inflammatory and antioxidant properties of Helichrysum italicum. J Pharm Pharmacol 2002;54:365–71. https://doi.org/10.1211/0022357021778600. ; Guerrini, A, Saccheti, G, Rossi, D, Paganetto, G, Muzzoli, M, Andreotti, E, et al. Bioactivities of Piper aduncum L. and Piper obliquum Ruiz & Pavon (Piperaceae) essential oil from Easter Ecuador. Environ Toxicol Pharmacol 2002;27;39–48. ; Cysne, JB, Canuto, KM, Pessoa, ODL, Nunes, EP, Silveira, ER. Leaf essential oils of four Piper species from the state of Ceará—northeast of Brazil. J Baz Chem Soc 2005;16:1378-81. ; Regasini, LO, Cotinguiba, F, Passerini, GD, Bolzani, VS, Cicarelli, RMB, Kato, MJ, et al. Trypanocidal activity of Piper arboreum and Piper tuberculatum (Piperaceae). Rev Bras Farmacog 2009a;19:199–03. https://doi.org/10.1590/s0102-695x2009000200003. ; Regasini, LO, Cotinguiba, V, Morandim, AA, Kato, MJ, Scorzoni, L, Mendes-Giannini, MJS, et al. Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts. Afr J Biotechnol 2009b;8:2866–70. ; Botsaris, AS. As fórmulas mágicas das plantas: como utilizar a fitoterapia no tratamento de doenças simples, 2nd ed. Rio de Janeiro: Record: Nova Era; 1997. ; Valadares, ACF, Alves, CCF, Alves, JM, De Deus, IPB, Oliveira-Filho, JG, Santos, TCL, et al. Essential oils from Piper aduncum inflorescences and leaves: chemical composition and antifungal activity against Sclerotinia sclerotiorum. An Acad Bras Ciênc 2018;90:2691–9. https://doi.org/10.1590/0001-3765201820180033. ; Villamizar, LH, Das Graças, CM, Andrade, J, Teixeira, ML, Soares, MJ. Linalool a Piper aduncum essential oil component, has selective activity against Trypanosoma cruzi trypomastigote forms at 4 °C. Mem Inst Oswaldo Cruz 2017;112:131–9. https://doi.org/10.1590/0074-02760160361. ; Mamood, SNH, Hidayatulfathi, O, Budin, SB, Ahmad Rohi, G. The formulation of the essential oil of Piper aduncum Linnaeus (Piperales: Piperaceae) increases its efficacy as an insect repellent. B Entomol Res 2017;107:49–57. https://doi.org/10.1017/s0007485316000614. ; Guimarães, EF, Valente, MC. Piperáceas—Piper. Flora Ilustrada Catarinense, Itajaí: Santa Catarina; 2001:104 p. ; Lago, JHG, Ramos, CS, Casanova, DC, Morandim, A, Bergano, DC, Cavalheiro, AJ, et al. Benzoic acid derivatives from Piper species and their fungitoxic activity against Clodosporium cladosporioides and C. shaerospermum. J Nat Prod 2004;67:1783–8. https://doi.org/10.1021/np030530j. ; Morais, DL, Kaplan, MAC, Santos, PO, Guimarães, EF. Estudos fitoquímicos e farmacológicos de Piper gaudichaudianum Kunth (Piperaceae). Rev Bras Farmacog 2007;82:29–32. ; Puhl, MC, Cortez, DA, Ueda-Nakamura, T, Nakamura, CV, Filho, BP. Antimicrobial activity of Piper gaudichaudianum Kuntze and its synergism with differents antibiotics. Molecules 2011;16:9925–38. https://doi.org/10.3390/molecules16129925. ; Loureiro, RJ, Roque, F, Rodrigues, AT, Herdeiro, MT, Ramalheira, E. O uso de antibióticos e as resistências bacterianas: breves notas sobre a sua evolução. Rev Port Saúde Púb 2016;34:77–84. https://doi.org/10.1016/j.rpsp.2015.11.003. ; Kohl, T, Pontarolo, GH, Pedrassani, D. Resistência antimicrobiana de bactérias isoladas de amostras de animais atendidos em hospital veterinário. Saúde Meio Ambiente 2016;5:115–27. https://doi.org/10.24302/sma.v5i2.1197. ; Wasicky, R. Uma modificação do aparelho de clevenger para extração de óleos essenciais. Rev Fac Farm e Bioq 1963;1:77–81. ; Linstrom, PJ, Mallard, WG, editors. NIST Chemistry Webbook. Available from: http://webbook.nist.gov [Accessed at June 2016].book-chapter. ; Wiley Registry of Mass Spectral Data, 6th ed. New York: Wiley-Interscience; 1994. ; Adams, RP. Identification of essential oil components by gas chromatography/mass spectroscopy. Carol Stream: Allured Publishing Corporation; 2007. ; Javadpour, MM, Juban, MM, LO, WC, Bishop, SM, Alberty, JB, Mann, CM, et al. A new method for determine the minimum inhibitory concentration of essential oils. J Appl Microbiol 1996;84:538–44. ; NCCLS. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. USA: Wayne, NIH; 2003. ; Coutinho, HDM, Costa, JGM, Siqueira, JPJr, Lima, EO. In vitro anti-staphylococcal activity of Hyptis martiusii Benth against methicillin-resistant Staphylococcus aureus—MRSA strains. Braz J Pharmacogn 2008a;18:670–5. https://doi.org/10.1590/s0102-695x2008000500005. ; Palazzolo, E, Laudicina, VA, Germanà, MA. Current and potential use of Citrus essential oils. Cur Org Chem 2013;17:3042–9. https://doi.org/10.2174/13852728113179990122. ; Péres, VF, Moura, DJ, Sperotto, AR, Damasceno, FC, Caramão, EB, Zini, CA, et al. Chemical composition and cytotoxic, mutagenic and genotoxic activities of the essential oil from Piper gaudichaudianum Kunth leaves. Food Chem Toxicol 2009;47:2385–9. https://doi.org/10.1016/j.fct.2009.06.035. ; Almeida, CA, Mariana, MBA, Francisco, CMC, Oliveira, MR, Rodrigues, IA, Bizzo, HR, et al. Piper essential oils inhibit Rhizopus oryzae growth, biofilm formation, and rhizopuspepsin activity. Can J Infect Dis Med 2018;2018:1–7. https://doi.org/10.1155/2018/5295619. ; Schindler, B, Heinzmann, BM. Piper gaudichaudianum Kunth: seasonal characterization of the essential oil chemical composition of leaves and reproductive organs. Braz Arch Biol Technol 2017;60:1–12. https://doi.org/10.1590/1678-4324-2017160441. ; Silva, JA, Oliveira, FF, Guedes, ES, Bittencourt, MAL, Oliveira, RA. Antioxidant activity of Piper arboreum, Piper dilatatum, and Piper divaricatum. Rev Bras Plantas Med 2014;16:700–6. https://doi.org/10.1590/1983-084x/13_097. ; Telascrea, M, Araújo, CC, Marques, MOM, Facanali, R, Moraes, PLR, Cavalheiro, AJ. Essential oil from leaves of Cryptocarya mandioccana Meisner (Lauraceae): Composition and intraspecific chemical variability. Biochem System Ecol 2007;35:222–32. https://doi.org/10.1016/j.bse.2006.09.015. ; Holley, RA, Patel, D. Improvement in shelf-life and safety of perishable foods by plant essential oils and smoke antimicrobials. Food Microbiol 2005;22:273–92. https://doi.org/10.1016/j.fm.2004.08.006. ; Oladimeji, FA, Orafidiya, LO, Okeke, IN. Physical properties and antimicrobial activities of leaf essential oils of Lippia multiflora Moldenke. Int J Aromatherapy 2004;14:162–8. https://doi.org/10.1016/j.ijat.2004.09.011. ; Hanamanthagouda, MS, Kakkalameli, SB, Naik, PM, Nagella, P, Seetharamareddy, HR, Murthy, HN. Essential oils of Lavandula bipinnata and their antimicrobial activities. Food Chem 2010;118:836–9. https://doi.org/10.1016/j.foodchem.2009.05.032. ; Monzote, L, Scull, R, Cos, P, Setzer, WN. Essential oil from Piper aduncum: chemical analysis, antimicrobial assessment, and literature review. Medicines 2017;4:40–9. https://doi.org/10.3390/medicines4030049. ; Wagner, H, Ulrich-Merzenich, G. Synergy research: approaching a new generation of phytopharmaceuticals. Phytomedicine 2009;16:97–10. https://doi.org/10.1016/j.phymed.2008.12.018. ; Coutinho, HDM, Costa, JG, Lima, EO, Falcão-Silva, VS, Siqueira-Júnior, JP. Enhancement of the antibiotic activity against a multiresistant Escherichia coli by Mentha arvensis L. and chlorpromazine. Chemotherapy 2008b;54:328–30. https://doi.org/10.1159/000151267. ; Azzopardi, AEL, Ferguson, DW. The enhanced permeability retention effect: a new paradigm for drug targeting in infection. J Antimicrob Chemother 2013;68:257–74. https://doi.org/10.1093/jac/dks379. ; Guimarães, DO, Momesso, LS, Pupo, MT. Antibióticos: importância terapêutica e perspectivas para descobertas e desenvolvimento de novos agentes. Quím Nova 2010;33:667–79. https://doi.org/10.1590/s0100-40422010000300035. ; McMurry, L, Petrucci, RE, Levy, SB. Active efflux of tetracycline encoded byfour genetically different tetracycline resistance determinants in Escherichia coli. Proc Natl Acad Sci USA 1980;77:3974–77. https://doi.org/10.1073/pnas.77.7.3974. ; Van Bambeke, F, Glupczynski, Y, Plesiat, P, Pechere, JC, Tulkens, PM. Antibiotic ef flux pumps in prokaryotic cells: occurrence, im-pact on resistance and strategies for the future of antimicrobial therapy. J Antimicrob Chemother 2003;51:1055–65. https://doi.org/10.1093/jac/dkg224. Contributed Indexing: Keywords: Piperaceae; antibacterial activity; essential oil; modulation Substance Nomenclature: 0 (Anti-Bacterial Agents) ; 0 (Oils, Volatile) ; 0 (Plant Oils) ; 0 (Sesquiterpenes) ; 0 (Sesquiterpenes, Germacrane) ; 0 (beta copaene) ; 7XV9L96SJJ (spathulenol) Entry Date(s): Date Created: 20200717 Date Completed: 20211027 Latest Revision: 20211027 Update Code: 20240513

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Gas chromatography coupled to mass spectrometry (GC-MS) characterization and evaluation of antibacterial bioactivities of the essential oils from Piper arboreum Aubl., Piper aduncum L. e Piper gaudichaudianum Kunth.