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Chemical profile and antioxidant potency of essential oils (EOs) of Thymus quinquecostatus Celak. (thyme oils) obtained from Loess Plateau in China had been studied. 130 constituents of thyme oils were determined using gas chromatography-mass spectrometry (GC-MS) and carvacrol ethyl ether was firstly reported as a new natural product, which has been used as a synthetic flavoring substance with no safety concern. The thyme oils showed the anti-oxidant activity using 2,2 diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS), ferric reducing antioxidant power (FRAP) and thiobarbituric acid reactive substances (TBARS) and conferred protection against oxidative stress in zebrafish. In addition, a class of carvacrol analogues was found to develop as potential natural antioxidant products of thyme oils from Loess Plateau by the correlation analysis. YL-thyme oil performed the best antioxidant activity in this research, which could be recommended as preferred sources of thyme oils. Furthermore, YL-thyme oil exhibited a potent antioxidant capacity by reactive oxygen species (ROS) scavenging, enhancing the endogenous antioxidant system, inhibiting lipid peroxidation and activation of Keap1/Nrf2 pathway in zebrafish.

Titel:	Chemical composition and anti-oxidant potential on essential oils of Thymus quinquecostatus Celak. from Loess Plateau in China, regulating Nrf2/Keap1 signaling pathway in zebrafish.
Autor/in / Beteiligte Person:	He, T ; Li, X ; Wang, X ; Xu, X ; Yan, X ; Sun, S ; Dong, Y ; Ren, X ; Liu, X ; Wang, Y ; Sui, H ; Xia, Q ; She, G
Zeitschrift:	Scientific reports, Jg. 10 (2020-07-09), Heft 1, S. 11280
Veröffentlichung:	London : Nature Publishing Group, copyright 2011-, 2020
Medientyp:	academicJournal
ISSN:	2045-2322 (electronic)
DOI:	10.1038/s41598-020-68188-8
Schlagwort:	Animals Antioxidants chemistry China Cymenes chemistry Gas Chromatography-Mass Spectrometry Multivariate Analysis Oils, Volatile chemistry Oxidative Stress Principal Component Analysis Reactive Oxygen Species metabolism Signal Transduction Thiobarbituric Acid Reactive Substances Zebrafish Antioxidants pharmacology Carrier Proteins metabolism NF-E2-Related Factor 2 metabolism Oils, Volatile pharmacology Thymus Plant chemistry Zebrafish Proteins metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Sci Rep] 2020 Jul 09; Vol. 10 (1), pp. 11280. <i>Date of Electronic Publication: </i>2020 Jul 09. MeSH Terms: Antioxidants / pharmacology ; Carrier Proteins / metabolism ; NF-E2-Related Factor 2 / metabolism ; Oils, Volatile / pharmacology ; Thymus Plant / chemistry ; Zebrafish Proteins / metabolism ; Animals ; Antioxidants / chemistry ; China ; Cymenes / chemistry ; Gas Chromatography-Mass Spectrometry ; Multivariate Analysis ; Oils, Volatile / chemistry ; Oxidative Stress ; Principal Component Analysis ; Reactive Oxygen Species / metabolism ; Signal Transduction ; Thiobarbituric Acid Reactive Substances ; Zebrafish References: Ďuračková, Z. Some current insights into oxidative stress. Physiol. Res. 59, 459 (2010). (PMID: 19929132) ; Reuter, S., Gupta, S. C., Chaturvedi, M. M. & Aggarwal, B. B. 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(PMID: 10.1371/journal.pone.0092246246586573962395) Substance Nomenclature: 0 (Antioxidants) ; 0 (Carrier Proteins) ; 0 (Cymenes) ; 0 (Keap1a protein, zebrafish) ; 0 (NF-E2-Related Factor 2) ; 0 (Oils, Volatile) ; 0 (Reactive Oxygen Species) ; 0 (Thiobarbituric Acid Reactive Substances) ; 0 (Zebrafish Proteins) ; 0 (nfe2l2a protein, zebrafish) ; 9B1J4V995Q (carvacrol) Entry Date(s): Date Created: 20200711 Date Completed: 20210125 Latest Revision: 20210709 Update Code: 20240513 PubMed Central ID: PMC7347579

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Chemical composition and anti-oxidant potential on essential oils of Thymus quinquecostatus Celak. from Loess Plateau in China, regulating Nrf2/Keap1 signaling pathway in zebrafish.