Chemical characterization and bioactivity of the essential oil from Santolina insularis , a Sardinian endemism.
In: Natural product research, Jg. 36 (2022), Heft 1, S. 445-449
academicJournal
Zugriff:
Santolina insularis is a Sardinian endemism that is widely used in traditional medicine. The essential oil was obtained with a yield of 2.7% and is mainly characterized by β-phellandrene (22.6%), myrcene (11.4%) and artemisia ketone (7.6%). The oil significantly reduced NO production without affecting macrophages viability. In addition, it substantially inhibited the expression of two key pro-inflammatory enzymes, iNOS and COX-2 (71% and 25% at 0.54 mg/mL). Furthermore, the oil had a promising antifungal activity being Cryptococcus neoformans (MIC = 0.13 mg/mL) and the majority of dermatophytes (MIC = 0.13 mg/mL) the most susceptible fungi. Moreover, it significantly decreased the yeast-to-hypha transition (80% inhibition at 0.13 mg/mL) on C. albicans long before showing inhibitory effects. Overall, these results show that S. insularis could be applied in the treatment of fungal infections and associated inflammatory response.
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Chemical characterization and bioactivity of the essential oil from Santolina insularis , a Sardinian endemism.
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Autor/in / Beteiligte Person: | Alves-Silva, JM ; Piras, A ; Porcedda, S ; Falconieri, D ; Maxia, A ; Gonçalves, MJ ; Cruz, MT ; Salgueiro, L |
Zeitschrift: | Natural product research, Jg. 36 (2022), Heft 1, S. 445-449 |
Veröffentlichung: | Milton Park, UK : Taylor & Francis Health Sciences, c2003-, 2022 |
Medientyp: | academicJournal |
ISSN: | 1478-6427 (electronic) |
DOI: | 10.1080/14786419.2020.1774764 |
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