Einzeltreffer — DigiBib

The brain's relationship to essential hypertension is primarily understood to be that of an end-organ, damaged late in life by stroke or dementia. Emerging evidence, however, shows that heightened blood pressure (BP) early in life and prior to traditionally defined hypertension, relates to altered brain structure, cerebrovascular function, and cognitive processing. Deficits in cognitive function, cerebral blood flow responsivity, volumes of brain areas, and white matter integrity all relate to increased but prehypertensive levels of BP. Such relationships may be observed as early as childhood. In this review, we consider the basis of these relationships by examining the emergence of putative causative factors for hypertension that would impact or involve brain function/structure, e.g., sympathetic nervous system activation and related endocrine and inflammatory activation. Currently, however, available evidence is not sufficient to fully explain the specific pattern of brain deficits related to heightened BP. Despite this uncertainty, the evidence reviewed suggests the value that early intervention may have, not only for reducing BP, but also for maintaining brain function.

Titel:	Is the Brain an Early or Late Component of Essential Hypertension?
Autor/in / Beteiligte Person:	Jennings, JR ; Muldoon, MF ; Sved, AF
Zeitschrift:	American journal of hypertension, Jg. 33 (2020-05-21), Heft 6, S. 482-490
Veröffentlichung:	2013- : Oxford : Oxford University Press ; <i>Original Publication</i>: [New York, NY] : Elsevier, [c1988-, 2020
Medientyp:	academicJournal
ISSN:	1941-7225 (electronic)
DOI:	10.1093/ajh/hpaa038
Schlagwort:	Age Factors Animals Brain pathology Essential Hypertension pathology Essential Hypertension psychology Humans Prognosis Risk Factors Blood Pressure Brain blood supply Cerebrovascular Circulation Cognition Essential Hypertension physiopathology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural; Review Language: English [Am J Hypertens] 2020 May 21; Vol. 33 (6), pp. 482-490. MeSH Terms: Blood Pressure* ; Cerebrovascular Circulation* ; Cognition* ; Brain / blood supply ; Essential Hypertension / physiopathology ; Age Factors ; Animals ; Brain / pathology ; Essential Hypertension / pathology ; Essential Hypertension / psychology ; Humans ; Prognosis ; Risk Factors References: J Hum Hypertens. 2005 Dec;19(12):951-69. (PMID: 16195709) ; Psychosom Med. 2003 Jan-Feb;65(1):46-62. (PMID: 12554815) ; Exp Physiol. 2017 May 1;102(5):523-532. (PMID: 28273684) ; Psychosom Med. 1994 Sep-Oct;56(5):449-56. (PMID: 7809345) ; Biol Psychol. 2005 Sep;70(1):44-51. (PMID: 16038773) ; Curr Hypertens Rep. 2016 Jul;18(7):59. (PMID: 27278369) ; Stroke. 2011 Sep;42(9):2672-713. (PMID: 21778438) ; J Physiol. 2015 Jul 15;593(14):3065-75. 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Is the Brain an Early or Late Component of Essential Hypertension?