Chemical composition, antioxidant and cytotoxic activity of Artemisia gmelinii essential oil growing wild in Kashmir valley.

Qadir, M ; Maurya, AK ; et al.

In: Natural product research, Jg. 34 (2020-11-01), Heft 22, S. 3289-3294

academicJournal

The present study was carried to observe the phytochemical profile of aromatic constituents of Artemisia gmelinni essential oil using GC-FID, GC-MS and 13 C NMR and to evalute anticancer and antioxidant activities. Twenty chemical constituents were detected from EO accounting 92.05% of total oil composition. Oxygenated monoterpenes (73.64%) were dominant class of compounds. The major constituents are isoascaridol (29.70%), alpha-terpinolene (25.37%), phellandrene (9.26%) and ascaridole (4.17%). Ascaridole and isoascaridole are first time identified to be the constituents of this essential oil. The essential oil effectively inhibit the growth of cancer cells and showed maximum anti-proliferative activity at 125µg/mL concentration, but highest inhibition in cell growth was found in A-549 cell line. Our study revealed that EO was effective in restricting the migration of A-549 cells up to 15% than control at 125 µg/mL concentration. The essential oil also showed moderate antioxidant activity.

Titel:	Chemical composition, antioxidant and cytotoxic activity of Artemisia gmelinii essential oil growing wild in Kashmir valley.
Autor/in / Beteiligte Person:	Qadir, M ; Maurya, AK ; Waza, AA ; Agnihotri, VK ; Shah, WA
Zeitschrift:	Natural product research, Jg. 34 (2020-11-01), Heft 22, S. 3289-3294
Veröffentlichung:	Milton Park, UK : Taylor & Francis Health Sciences, c2003-, 2020
Medientyp:	academicJournal
ISSN:	1478-6427 (electronic)
DOI:	10.1080/14786419.2018.1557178
Schlagwort:	A549 Cells Antineoplastic Agents, Phytogenic chemistry Antioxidants chemistry Cell Movement drug effects Cyclohexane Monoterpenes analysis Gas Chromatography-Mass Spectrometry Growth Inhibitors chemistry Growth Inhibitors pharmacology Humans Magnetic Resonance Spectroscopy Monoterpenes analysis Monoterpenes chemistry Peroxides analysis Antineoplastic Agents, Phytogenic pharmacology Antioxidants pharmacology Artemisia chemistry Oils, Volatile chemistry Oils, Volatile pharmacology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Nat Prod Res] 2020 Nov; Vol. 34 (22), pp. 3289-3294. <i>Date of Electronic Publication: </i>2019 Jan 08. MeSH Terms: Antineoplastic Agents, Phytogenic / pharmacology ; Antioxidants / pharmacology ; Artemisia / chemistry ; Oils, Volatile / chemistry ; Oils, Volatile / *pharmacology ; A549 Cells ; Antineoplastic Agents, Phytogenic / chemistry ; Antioxidants / chemistry ; Cell Movement / drug effects ; Cyclohexane Monoterpenes / analysis ; Gas Chromatography-Mass Spectrometry ; Growth Inhibitors / chemistry ; Growth Inhibitors / pharmacology ; Humans ; Magnetic Resonance Spectroscopy ; Monoterpenes / analysis ; Monoterpenes / chemistry ; Peroxides / analysis Contributed Indexing: Keywords: Antioxidant; Artemisia gmelinni; GC-FID; MTT; wound healing Substance Nomenclature: 0 (Antineoplastic Agents, Phytogenic) ; 0 (Antioxidants) ; 0 (Cyclohexane Monoterpenes) ; 0 (Growth Inhibitors) ; 0 (Monoterpenes) ; 0 (Oils, Volatile) ; 0 (Peroxides) ; 1718D0GEVJ (ascaridole) Entry Date(s): Date Created: 20190109 Date Completed: 20210108 Latest Revision: 20210108 Update Code: 20231215

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