[Essential tremor: state of the art].
In: Der Nervenarzt, Jg. 89 (2018-04-01), Heft 4, S. 394-399
academicJournal
Zugriff:
Essential tremor (ET) is currently classified as a syndrome rather than a unique disease, primarily involving monosymptomatic action tremor in both hands. Different etiologies are presumed to underlie this condition. Currently only a few monogenetic conditions are known to present with this syndrome. If accompanied by additional symptoms that do not in themselves constitute a new syndrome, such as abnormal tandem gait or postures, the syndrome should be diagnosed as "ET plus". ET is associated with abnormal rhythmic activation of the cerebello-thalamo-cortical tremor circuit. Despite its strong heritability, the genetics of ET have not been elucidated as yet. Age-correlated tremor is one of the presumed subgroups of ET. Late onset is associated with a shortened life expectancy. From a treatment perspective, propranolol and primidone represent the drugs of first choice, followed by topiramate. Deep brain stimulation of the Vim nucleus of the thalamus is a proven treatment option in severely affected patients.
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[Essential tremor: state of the art].
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Autor/in / Beteiligte Person: | Deuschl, G ; Berg, D |
Zeitschrift: | Der Nervenarzt, Jg. 89 (2018-04-01), Heft 4, S. 394-399 |
Veröffentlichung: | Berlin : Springer Verlag, 2018 |
Medientyp: | academicJournal |
ISSN: | 1433-0407 (electronic) |
DOI: | 10.1007/s00115-017-0475-z |
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