Einzeltreffer — DigiBib

Background: Mood disorder accounts for 13 % of global disease burden. And while therapeutic agents are available, usually orally administered, most have unwanted side effects, and thus making the inhalation of essential oils (EOs) an attractive alternative therapy. Rosmarinus officinalis EO (ROEO), Mediterranean ROEO reported to improve cognition, mood, and memory, the effect on stress of which has not yet been determined. Here, the anti-stress effect of ROEO on stress was evaluated in vivo and in vitro.

Methods: Six-week-old male ICR mice were made to inhale ROEO and subjected to tail suspension test (TST). To determine the neuronal differentiation effect of ROEO in vitro, induction of ROEO-treated PC12 cells differentiation was observed. Intracellular acetylcholine and choline, as well as the Gap43 gene expression levels were also determined.

Results: Inhalation of ROEO significantly decreased the immobility time of ICR mice and serum corticosterone level, accompanied by increased brain dopamine level. Determination of the underlying mechanism in vitro revealed a PC12 differentiation-induction effect through the modulation of intracellular acetylcholine, choline, and Gap43 gene expression levels. ROEO activates the stress response system through the NGF pathway and the hypothalamus-pituitary-adrenal axis, promoting dopamine production and secretion. The effect of ROEO may be attributed to its bioactive components, specifically to α-pinene, one of its major compounds that has anxiolytic property.

Conclusions: The results of this study suggest that ROEO inhalation has therapeutic potential against stress-related psychiatric disorders.

Titel:	Anti-stress and neuronal cell differentiation induction effects of Rosmarinus officinalis L. essential oil.
Autor/in / Beteiligte Person:	Villareal, MO ; Ikeya, A ; Sasaki, K ; Arfa, AB ; Neffati, M ; Isoda, H
Zeitschrift:	BMC complementary and alternative medicine, Jg. 17 (2017-12-22), Heft 1, S. 549
Veröffentlichung:	London : BioMed Central, [2001-2019], 2017
Medientyp:	academicJournal
ISSN:	1472-6882 (electronic)
DOI:	10.1186/s12906-017-2060-1
Schlagwort:	Acetylcholinesterase metabolism Animals Behavior, Animal drug effects Catecholamines metabolism GAP-43 Protein metabolism Male Mice Mice, Inbred ICR PC12 Cells Rats Brain Chemistry drug effects Cell Differentiation drug effects Neurons drug effects Oils, Volatile pharmacology Rosmarinus Stress, Psychological metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [BMC Complement Altern Med] 2017 Dec 22; Vol. 17 (1), pp. 549. <i>Date of Electronic Publication: </i>2017 Dec 22. MeSH Terms: Rosmarinus* ; Brain Chemistry / drug effects ; Cell Differentiation / drug effects ; Neurons / drug effects ; Oils, Volatile / pharmacology ; Stress, Psychological / *metabolism ; Acetylcholinesterase / metabolism ; Animals ; Behavior, Animal / drug effects ; Catecholamines / metabolism ; GAP-43 Protein / metabolism ; Male ; Mice ; Mice, Inbred ICR ; PC12 Cells ; Rats References: Toxicol In Vitro. 2008 Aug;22(5):1128-35. (PMID: 18406567) ; BMC Complement Altern Med. 2014 Jul 07;14 :225. (PMID: 25002023) ; Curr Drug Targets. 2013 Jul;14(8):872-9. (PMID: 23531112) ; Cleve Clin J Med. 2006 Apr;73(4):351-3, 356-61. (PMID: 16610395) ; Nat Prod Commun. 2012 Nov;7(11):1539-44. (PMID: 23285826) ; J Perianesth Nurs. 2009 Dec;24(6):348-55. (PMID: 19962101) ; Biol Pharm Bull. 2004 Aug;27(8):1257-60. (PMID: 15305032) ; Behav Brain Res. 2013 Feb 1;238:86-94. (PMID: 23085339) ; Biol Pharm Bull. 2005 Feb;28(2):378-9. (PMID: 15684505) ; Int J Neurosci. 2003 Jan;113(1):15-38. (PMID: 12690999) ; Int Immunopharmacol. 2013 Jun;16(2):184-90. (PMID: 23602914) ; Food Chem. 2013 Jan 15;136(2):999-1005. (PMID: 23122155) ; BMC Complement Altern Med. 2015 Mar 06;15:43. (PMID: 25881143) ; Curr Neuropharmacol. 2006 Oct;4(4):293-304. (PMID: 18654638) ; Arch Gen Psychiatry. 2008 May;65(5):521-31. (PMID: 18458204) ; Neurosci Biobehav Rev. 2008 Aug;32(6):1174-84. (PMID: 18534678) ; Mol Cell. 2014 Apr 24;54(2):281-8. (PMID: 24766892) ; Phytomedicine. 2013 Jan 15;20(2):172-7. (PMID: 23207249) ; Science. 2002 May 31;296(5573):1648-9. (PMID: 12040181) ; Behav Brain Res. 2006 Sep 25;172(2):240-9. (PMID: 16780969) ; Phytomedicine. 2007 Sep;14(9):613-20. (PMID: 17482442) ; Psychopharmacology (Berl). 1985;85(3):367-70. (PMID: 3923523) ; Biol Pharm Bull. 2002 Dec;25(12):1629-33. (PMID: 12499653) ; J Ethnopharmacol. 2010 Sep 15;131(2):451-8. (PMID: 20633629) ; Phytother Res. 2013 Feb;27(2):306-11. (PMID: 22581512) ; Commun Integr Biol. 2009 Jul;2(4):350-2. (PMID: 19721888) ; Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jan;29(1):47-53. (PMID: 15610944) ; Front Neuroendocrinol. 2008 May;29(2):268-72. (PMID: 18067954) ; J Nat Med. 2013 Oct;67(4):876-80. (PMID: 23436179) ; Phytother Res. 2002 Jun;16(4):301-8. (PMID: 12112282) ; Nat Neurosci. 2000 Feb;3(2):120-5. (PMID: 10649566) ; Chem Biol Interact. 2015 Dec 5;242:163-9. (PMID: 26415617) ; J Tradit Complement Med. 2015 Feb 23;6(2):140-5. (PMID: 27114936) ; Food Chem Toxicol. 2008 Feb;46(2):446-75. (PMID: 17996351) ; CNS Drugs. 2006;20(4):257-80. (PMID: 16599645) ; Neurosci Biobehav Rev. 2005;29(4-5):571-625. (PMID: 15890404) ; Phytother Res. 2014 Nov;28(11):1599-605. (PMID: 24802524) ; Prog Neuropsychopharmacol Biol Psychiatry. 2012 Aug 7;38(2):276-84. (PMID: 22542869) ; Z Naturforsch C. 1991 Nov-Dec;46(11-12):1067-72. (PMID: 1817516) ; Evid Based Complement Alternat Med. 2014;2014:820126. (PMID: 25028591) ; J Biomed Mater Res A. 2013 Jan;101(1):185-94. (PMID: 22829561) Contributed Indexing: Keywords: Catecholamines; Cell differentiation; Inhalation; Nerve growth factor; Rosemary essential oil Substance Nomenclature: 0 (Catecholamines) ; 0 (GAP-43 Protein) ; 0 (Oils, Volatile) ; 8LGU7VM393 (rosemary oil) ; EC 3.1.1.7 (Acetylcholinesterase) Entry Date(s): Date Created: 20171224 Date Completed: 20180103 Latest Revision: 20220330 Update Code: 20231215 PubMed Central ID: PMC5741888

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Anti-stress and neuronal cell differentiation induction effects of Rosmarinus officinalis L. essential oil.