Structural differences in impaired verbal fluency in essential tremor patients compared to healthy controls.
In: Brain and behavior, Jg. 7 (2017-05-15), Heft 7, S. e00722
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Zugriff:
Objective: We wanted to identify differences in grey and white matter in essential tremor patients compared to controls in the non-motor domain, using the example of impaired verbal fluency.
Background: A disturbance of verbal fluency in essential tremor patients compared to healthy controls is behaviorally well described.
Methods: Voxel-based morphometry and tract-based spatial statistics were used to analyze structural differences in grey and white matter in 19 essential tremor patients compared to 23 age- and gender-matched controls.
Results: Several significant observations were made. (I) There was less grey matter in the predominantly right precuneus in the essential tremor group compared to controls [ p < .001]. (II) In ET patients mean, axial, and radial diffusivity values broadly correlated with the tremor rating scale, pronounced in fronto-parietal regions [ p < .05]. (III) In ET patients there was a significant decline in fractional anisotropy values in the corpus callosum in the correlation with verbal fluency results [ p < .05]; by inclusion of the tremor rating scale as covariate of no interest this significance was however diminished to a tendency ( p < .1). No significant results were found in these within-group correlations in grey matter analyses for ET patients ( p > .05).
Conclusion: The present results indicate that non-motor symptoms such as verbal fluency (VBF) in ET have a structural substrate; their reproduction requires the integration of potential environmental plasticity effects, differentiation into individual clinical subtypes and a careful handling with methodological peculiarities of structural MR imaging.
Titel: |
Structural differences in impaired verbal fluency in essential tremor patients compared to healthy controls.
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Autor/in / Beteiligte Person: | Pelzer, EA ; Nelles, C ; Pedrosa, DJ ; Eggers, C ; Burghaus, L ; Melzer, C ; Tittgemeyer, M ; Timmermann, L |
Zeitschrift: | Brain and behavior, Jg. 7 (2017-05-15), Heft 7, S. e00722 |
Veröffentlichung: | Hoboken, NJ : John Wiley & Sons, 2017 |
Medientyp: | academicJournal |
ISSN: | 2162-3279 (electronic) |
DOI: | 10.1002/brb3.722 |
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