Melaleuca alternifolia essential oil nanoparticles ameliorate the hepatic antioxidant/oxidant status of silver catfish experimentally infected with Pseudomonas aeruginosa.

Souza, CF ; Baldissera, MD ; et al.

In: Microbial pathogenesis, Jg. 108 (2017-07-01), S. 61-65

academicJournal

Oxidative stress has been recognized as a conjoint pathological mechanism that contributes to initiation and progression of liver injury, such as that caused by bacterial diseases. Natural antioxidants are considered a rational curative strategy to prevent and cure hepatic diseases involved with oxidative stress. Thus, the aim of this study was to evaluate, for the first time, whether treatment with bactericidal Melaleuca alternifolia essential oil (TTO) nanoparticles prevents or reduces the hepatic damage in silver catfish (Rhamdia quelen) experimentally infected with Pseudomonas aeruginosa (PAO1). Liver samples from fish infected with P. aeruginosa showed increased thiobarbituric acid reactive substances (TBARS), protein carbonylation and advanced oxidation protein product (AOPP) levels, while catalase (CAT) activity was reduced compared to uninfected animals. The prophylactic treatment with nanoencapsulated TTO prevented these alterations. Based on this evidence, we concluded that P. aeruginosa infection causes hepatic damage, evidenced by increased TBARS, protein carbonylation and AOPP levels, which inhibits the antioxidant defense system, contributing to disease pathophysiology. Thus, this treatment may be considered an important approach for the prevention of hepatic oxidative damage caused by P. aeruginosa infection in fish.

Titel:	Melaleuca alternifolia essential oil nanoparticles ameliorate the hepatic antioxidant/oxidant status of silver catfish experimentally infected with Pseudomonas aeruginosa.
Autor/in / Beteiligte Person:	Souza, CF ; Baldissera, MD ; Guarda, NS ; Bollick, YS ; Moresco, RN ; Brusque, ICM ; Santos, RCV ; Baldisserotto, B
Zeitschrift:	Microbial pathogenesis, Jg. 108 (2017-07-01), S. 61-65
Veröffentlichung:	London ; Orlando : Academic Press, c1986-, 2017
Medientyp:	academicJournal
ISSN:	1096-1208 (electronic)
DOI:	10.1016/j.micpath.2017.05.016
Schlagwort:	Advanced Oxidation Protein Products metabolism Animals Anti-Bacterial Agents Catalase metabolism Disease Models, Animal Fish Diseases drug therapy Fish Diseases microbiology Fish Diseases pathology Liver injuries Liver metabolism Liver pathology Nanoparticles Oxidative Stress drug effects Plant Extracts pharmacology Protein Carbonylation Pseudomonas Infections microbiology Pseudomonas Infections physiopathology Tea Tree Oil therapeutic use Thiobarbituric Acid Reactive Substances metabolism Antioxidants metabolism Catfishes microbiology Liver drug effects Melaleuca chemistry Oxidants metabolism Pseudomonas Infections veterinary Pseudomonas aeruginosa pathogenicity Tea Tree Oil pharmacology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Microb Pathog] 2017 Jul; Vol. 108, pp. 61-65. <i>Date of Electronic Publication: </i>2017 May 06. MeSH Terms: Antioxidants / metabolism ; Catfishes / microbiology ; Liver / drug effects ; Melaleuca / chemistry ; Oxidants / metabolism ; Pseudomonas Infections / veterinary ; Pseudomonas aeruginosa / pathogenicity ; Tea Tree Oil / pharmacology ; Advanced Oxidation Protein Products / metabolism ; Animals ; Anti-Bacterial Agents ; Catalase / metabolism ; Disease Models, Animal ; Fish Diseases / drug therapy ; Fish Diseases / microbiology ; Fish Diseases / pathology ; Liver / injuries ; Liver / metabolism ; Liver / pathology ; Nanoparticles ; Oxidative Stress / drug effects ; Plant Extracts / pharmacology ; Protein Carbonylation ; Pseudomonas Infections / microbiology ; Pseudomonas Infections / physiopathology ; Tea Tree Oil / therapeutic use ; Thiobarbituric Acid Reactive Substances / metabolism Contributed Indexing: Keywords: Antioxidative therapy; Liver injury; Nanotechnology; Tea tree oil Substance Nomenclature: 0 (Advanced Oxidation Protein Products) ; 0 (Anti-Bacterial Agents) ; 0 (Antioxidants) ; 0 (Oxidants) ; 0 (Plant Extracts) ; 0 (Thiobarbituric Acid Reactive Substances) ; 68647-73-4 (Tea Tree Oil) ; EC 1.11.1.6 (Catalase) Entry Date(s): Date Created: 20170511 Date Completed: 20180108 Latest Revision: 20180108 Update Code: 20240513

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