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Delivery of the replicative helicase onto DNA is an essential step in the initiation of replication. In bacteria, DnaC (in Escherichia coli) and DnaI (in Bacillus subtilis) are representative of the two known mechanisms that assist the replicative helicase at this stage. Here, we establish that these two strategies cannot be regarded as prototypical of the bacterial domain since dnaC and dnaI (dna[CI]) are present in only a few bacterial phyla. We show that dna[CI] was domesticated at least seven times through evolution in bacteria and at the expense of one gene, which we rename dciA (dna[CI] antecedent), suggesting that DciA and Dna[CI] share a common function. We validate this hypothesis by establishing in Pseudomonas aeruginosa that DciA possesses the attributes of the replicative helicase-operating proteins associated with replication initiation.

Titel:	DciA is an ancestral replicative helicase operator essential for bacterial replication initiation.
Autor/in / Beteiligte Person:	Brézellec, P ; Vallet-Gely, I ; Possoz, C ; Quevillon-Cheruel, S ; Ferat, JL
Zeitschrift:	Nature communications, Jg. 7 (2016-11-10), S. 13271
Veröffentlichung:	[London] : Nature Pub. Group, 2016
Medientyp:	academicJournal
ISSN:	2041-1723 (electronic)
DOI:	10.1038/ncomms13271
Schlagwort:	Bacteria classification Bacteria enzymology Bacteria genetics Bacterial Proteins classification Bacterial Proteins metabolism DNA Helicases classification DNA Helicases metabolism DNA, Bacterial genetics DNA, Bacterial metabolism Escherichia coli Proteins genetics Escherichia coli Proteins metabolism Genome, Bacterial genetics Phylogeny Bacterial Proteins genetics DNA Helicases genetics DNA Replication Operator Regions, Genetic
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Nat Commun] 2016 Nov 10; Vol. 7, pp. 13271. <i>Date of Electronic Publication: </i>2016 Nov 10. MeSH Terms: DNA Replication* ; Operator Regions, Genetic* ; Bacterial Proteins / genetics ; DNA Helicases / genetics ; Bacteria / classification ; Bacteria / enzymology ; Bacteria / genetics ; Bacterial Proteins / classification ; Bacterial Proteins / metabolism ; DNA Helicases / classification ; DNA Helicases / metabolism ; DNA, Bacterial / genetics ; DNA, Bacterial / metabolism ; Escherichia coli Proteins / genetics ; Escherichia coli Proteins / metabolism ; Genome, Bacterial / genetics ; Phylogeny References: PLoS One. 2012;7(3):e33613. (PMID: 22442702) ; J Antimicrob Chemother. 1983 Aug;12(2):119-26. (PMID: 6413485) ; EMBO J. 1991 Jun;10(6):1579-84. (PMID: 2026151) ; Cell. 2013 Apr 11;153(2):438-48. (PMID: 23562643) ; Front Microbiol. 2015 Apr 09;6:281. (PMID: 25914684) ; Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18947-52. (PMID: 19028873) ; J Microbiol Methods. 2009 Sep;78(3):319-24. (PMID: 19615413) ; Res Microbiol. 2005 Mar;156(2):245-55. (PMID: 15748991) ; Virus Genes. 2002 Mar;24(2):163-71. (PMID: 12018708) ; Cold Spring Harb Perspect Biol. 2013 Jun 01;5(6):null. (PMID: 23613349) ; Mol Cell. 2016 Jan 21;61(2):287-96. (PMID: 26725007) ; J Biol Chem. 1998 Sep 18;273(38):24906-11. (PMID: 9733797) ; Mol Cell. 2003 Apr;11(4):1009-20. (PMID: 12718886) ; Nucleic Acids Res. 2014 Jan;42(Database issue):D633-42. (PMID: 24288368) ; Syst Biol. 2003 Oct;52(5):696-704. (PMID: 14530136) ; Proc Natl Acad Sci U S A. 1990 Feb;87(4):1278-82. (PMID: 2106132) ; Proc Natl Acad Sci U S A. 2005 May 31;102(22):8006-11. (PMID: 15911752) ; Nucleic Acids Res. 2004 Jan 1;32(Database issue):D138-41. (PMID: 14681378) ; Curr Biol. 2003 Aug 5;13(15):R594-6. (PMID: 12906810) ; Proc Natl Acad Sci U S A. 1998 May 12;95(10):5752-6. (PMID: 9576956) ; J Mol Biol. 2001 Jun 1;309(2):361-86. (PMID: 11371159) Substance Nomenclature: 0 (Bacterial Proteins) ; 0 (DNA, Bacterial) ; 0 (DnaC protein, E coli) ; 0 (DnaI protein, Bacillus subtilis) ; 0 (Escherichia coli Proteins) ; EC 3.6.4.- (DNA Helicases) Entry Date(s): Date Created: 20161111 Date Completed: 20180917 Latest Revision: 20181113 Update Code: 20240513 PubMed Central ID: PMC5109545

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DciA is an ancestral replicative helicase operator essential for bacterial replication initiation.