Rapid and robust reversion to essential thrombocythemia on treatment with Decitabine in a case of hydroxyurea-induced t-MDS/AML.
In: Clinical case reports, Jg. 4 (2015-11-15), Heft 1, S. 46-50
report
Zugriff:
Rapid remission of MDS/AML may be induced with Decitabine; however, significant megakaryocyte expansion and subsequent thrombocytosis may occur. Decitabine-mediated reversion of the MDS to benign ET via hypomethylation of JAK/STAT pathway repressors is one potential mechanism to explain this observed phenomenon.
Titel: |
Rapid and robust reversion to essential thrombocythemia on treatment with Decitabine in a case of hydroxyurea-induced t-MDS/AML.
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Autor/in / Beteiligte Person: | Horton, JD ; Arbini, AA ; Perle, MA ; Raphael, BG |
Zeitschrift: | Clinical case reports, Jg. 4 (2015-11-15), Heft 1, S. 46-50 |
Veröffentlichung: | Chichester, UK : John Wiley & Sons, 2015 |
Medientyp: | report |
ISSN: | 2050-0904 (print) |
DOI: | 10.1002/ccr3.431 |
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