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This study reports the biological synthesis of gold nanoparticles using essential oil of Nigella sativa (NsEO-AuNPs). The synthesized NsEO-AuNPs were characterized by UV-visible spectra, X-ray diffraction (XRD), FTIR and Transmission electron microscopy (TEM). UV-vis spectra of NsEO-AuNPs showed strong absorption peak at 540 nm. The X-ray diffraction analysis revealed crystalline nature of nanoparticle with distinctive facets (111, 200, 220 and 311 planes) of NsEO-AuNPs. The FTIR spectra recorded peaks at 3388, 2842, 1685, 1607, 1391 and 1018 cm(-1). TEM studies showed the spherical shape of nanoparticles and the particle size ranges between 15.6 and 28.4 nm. The antibacterial activity of NsEO-AuNPs was greater against Gram positive Staphylococcus aureus MTCC 9542 (16 mm) than Gram negative Vibrio harveyi MTCC 7771 (5 mm) at the concentration of 10 μg ml(-1). NsEO-AuNPs effectively inhibited the biofilm formation of S. aureus and V. harveyi by decreasing the hydrophobicity index (78% and 46% respectively). The in-vitro anti-lung cancer activity confirmed by MTT assay on the cell line of A549 carcinoma cells showed IC50 values of bulk Au at 87.2 μg ml(-1), N. sativa essential oil at 64.15 μg ml(-1) and NsEO-AuNPs at 28.37 μg ml(-1). The IC50 value showed that NsEO-AuNPs was highly effective in inhibiting the A549 lung cancer cells compared to bulk Au and N. sativa essential oil.

Titel:	Antibacterial, antibiofilm and cytotoxic effects of Nigella sativa essential oil coated gold nanoparticles.
Autor/in / Beteiligte Person:	Manju, S ; Malaikozhundan, B ; Vijayakumar, S ; Shanthi, S ; Jaishabanu, A ; Ekambaram, P ; Vaseeharan, B
Zeitschrift:	Microbial pathogenesis, Jg. 91 (2016-02-01), S. 129-35
Veröffentlichung:	London ; Orlando : Academic Press, c1986-, 2016
Medientyp:	academicJournal
ISSN:	1096-1208 (electronic)
DOI:	10.1016/j.micpath.2015.11.021
Schlagwort:	Anti-Bacterial Agents chemistry Anti-Bacterial Agents toxicity Cell Line Cell Survival drug effects Gold chemistry Gold toxicity Humans Nanoparticles chemistry Nanoparticles toxicity Oils, Volatile chemistry Oils, Volatile toxicity Plant Oils chemistry Plant Oils toxicity Staphylococcus aureus physiology Vibrio physiology Anti-Bacterial Agents pharmacology Biofilms drug effects Gold pharmacology Nigella sativa chemistry Oils, Volatile pharmacology Plant Oils pharmacology Staphylococcus aureus drug effects Vibrio drug effects
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Microb Pathog] 2016 Feb; Vol. 91, pp. 129-35. <i>Date of Electronic Publication: </i>2015 Dec 15. MeSH Terms: Anti-Bacterial Agents / pharmacology ; Biofilms / drug effects ; Gold / pharmacology ; Nigella sativa / chemistry ; Oils, Volatile / pharmacology ; Plant Oils / pharmacology ; Staphylococcus aureus / drug effects ; Vibrio / drug effects ; Anti-Bacterial Agents / chemistry ; Anti-Bacterial Agents / toxicity ; Cell Line ; Cell Survival / drug effects ; Gold / chemistry ; Gold / toxicity ; Humans ; Nanoparticles / chemistry ; Nanoparticles / toxicity ; Oils, Volatile / chemistry ; Oils, Volatile / toxicity ; Plant Oils / chemistry ; Plant Oils / toxicity ; Staphylococcus aureus / physiology ; Vibrio / physiology Contributed Indexing: Keywords: Antibacterial; Antibiofilm; AuNPs; Cytotoxicity; Essential oil; Infrared spectroscopy; Lung cancer cells; Transmission electron microscopy (TEM) Substance Nomenclature: 0 (Anti-Bacterial Agents) ; 0 (Oils, Volatile) ; 0 (Plant Oils) ; 7440-57-5 (Gold) Entry Date(s): Date Created: 20151226 Date Completed: 20161014 Latest Revision: 20161230 Update Code: 20231215

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Antibacterial, antibiofilm and cytotoxic effects of Nigella sativa essential oil coated gold nanoparticles.