Chemical composition, and cytotoxic, antioxidant and antibacterial activities of the essential oil from ginseng leaves.
In: Natural product communications, Jg. 9 (2014-06-01), Heft 6, S. 865-8
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Zugriff:
Panax ginseng C.A.Meyer is one of the most valuable traditional Chinese medicines. In this study, the essential oil of ginseng leaves (EOGL), collected using hydrodistillation and analyzed by GC/MS, contained a complex mixture of aliphatic (69.0%), terpenoid (21.5%) and aromatic compounds (2.4%). Among 54 components identified, the major ones were palmitic acid (36.1%), beta-farnesene (15.4%), linoleic acid (9.8%) and phytol (5.6%). In the cytotoxicity study, EOGL exhibited obvious cytotoxic activities against different cancer cell lines, including Hela, A549, ZR-75-1, HT-29, SGC7901 and B16 cells. Furthermore, Annexin V-FITC/PI staining assay indicated that EOGL can induce late apoptosis of ZR-75-1 cells, and the percentage of apoptotic cells increased in a concentration-dependent manner (0.9% to 5.6% and 67.4%). In addition to this, we also found that EOGL exhibited weak DPPH radical scavenging (12.0 +/- 0.4 mg/mL) and ABTS radical scavenging activities (1.6 +/- 0.1 mg/mL), and showed antibacterial activity against the Gram-positive bacteria, Staphylococcus aureus and Bacillus subtilis, and the Gram-negative bacterium, Escherichia coli. The data suggest that EOGL, which possesses important biological activities, especially significant anticancer activity, could be a potential medicinal resource.
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Chemical composition, and cytotoxic, antioxidant and antibacterial activities of the essential oil from ginseng leaves.
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Autor/in / Beteiligte Person: | Jiang, R ; Sun, L ; Wang, Y ; Liu, J ; Liu, X ; Feng, H ; Zhao, D |
Zeitschrift: | Natural product communications, Jg. 9 (2014-06-01), Heft 6, S. 865-8 |
Veröffentlichung: | 2019- : [Thousand Oaks, CA] : SAGE Publications ; <i>Original Publication</i>: Westerville, OH : Natural Product Communications, [2006]-[2018], 2014 |
Medientyp: | academicJournal |
ISSN: | 1934-578X (print) |
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