Einzeltreffer — DigiBib

E proteins are a special class of basic helix-loop-helix (bHLH) proteins that heterodimerize with many bHLH activators to regulate developmental decisions, such as myogenesis and neurogenesis. Daughterless (Da) is the sole E protein in Drosophila and is ubiquitously expressed. We have characterized two transcription activation domains (TADs) in Da, called activation domain 1 (AD1) and loop-helix (LH), and have evaluated their roles in promoting peripheral neurogenesis. In this context, Da heterodimerizes with proneural proteins, such as Scute (Sc), which is dynamically expressed and also contributes a TAD. We found that either one of the Da TADs in the Da/Sc complex is sufficient to promote neurogenesis, whereas the Sc TAD is incapable of doing so. Besides its transcriptional activation role, the Da AD1 domain serves as an interaction platform for E(spl) proteins, bHLH-Orange family repressors which antagonize Da/Sc function. We show that the E(spl) Orange domain is needed for this interaction and strongly contributes to the antiproneural activity of E(spl) proteins. We present a mechanistic model on the interplay of these bHLH factors in the context of neural fate assignment.

Titel:	Essential roles of Da transactivation domains in neurogenesis and in E(spl)-mediated repression.
Autor/in / Beteiligte Person:	Zarifi, I ; Kiparaki, M ; Koumbanakis, KA ; Giagtzoglou, N ; Zacharioudaki, E ; Alexiadis, A ; Livadaras, I ; Delidakis, C
Zeitschrift:	Molecular and cellular biology, Jg. 32 (2012-11-01), Heft 22, S. 4534-48
Veröffentlichung:	2023- : [Philadelphia] : Taylor & Francis ; <i>Original Publication</i>: [Washington, D.C.] : American Society for Microbiology, [c1981-, 2012
Medientyp:	academicJournal
ISSN:	1098-5549 (electronic)
DOI:	10.1128/MCB.00827-12
Schlagwort:	Amino Acid Sequence Animals Basic Helix-Loop-Helix Transcription Factors genetics Binding Sites Cell Line DNA-Binding Proteins genetics DNA-Binding Proteins metabolism Drosophila Proteins genetics Drosophila melanogaster genetics Drosophila melanogaster growth & development Gene Expression Regulation, Developmental Insecta Molecular Sequence Data Plasmids Polymerization Protein Binding Protein Structure, Secondary Protein Structure, Tertiary Repressor Proteins genetics Signal Transduction genetics Transcription Factors genetics Transcription Factors metabolism Transfection Basic Helix-Loop-Helix Transcription Factors metabolism Drosophila Proteins metabolism Drosophila melanogaster metabolism Neurogenesis genetics Repressor Proteins metabolism Transcriptional Activation
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Mol Cell Biol] 2012 Nov; Vol. 32 (22), pp. 4534-48. <i>Date of Electronic Publication: </i>2012 Sep 04. MeSH Terms: Transcriptional Activation* ; Basic Helix-Loop-Helix Transcription Factors / metabolism ; Drosophila Proteins / metabolism ; Drosophila melanogaster / metabolism ; Neurogenesis / genetics ; Repressor Proteins / *metabolism ; Amino Acid Sequence ; Animals ; Basic Helix-Loop-Helix Transcription Factors / genetics ; Binding Sites ; Cell Line ; DNA-Binding Proteins / genetics ; DNA-Binding Proteins / metabolism ; Drosophila Proteins / genetics ; Drosophila melanogaster / genetics ; Drosophila melanogaster / growth & development ; Gene Expression Regulation, Developmental ; Insecta ; Molecular Sequence Data ; Plasmids ; Polymerization ; Protein Binding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Repressor Proteins / genetics ; Signal Transduction / genetics ; Transcription Factors / genetics ; Transcription Factors / metabolism ; Transfection References: Neuron. 1999 Mar;22(3):451-61. (PMID: 10197526) ; Genes Dev. 1991 Jun;5(6):996-1008. 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(PMID: 8001118) ; Cell. 1994 Dec 2;79(5):875-84. (PMID: 8001124) ; Mol Cell Biol. 2004 Nov;24(21):9517-26. (PMID: 15485919) ; Cell. 2011 Nov 11;147(4):881-92. (PMID: 22078884) ; Genes Dev. 1998 Jul 1;12(13):2036-47. (PMID: 9649507) ; BMC Res Notes. 2009 Apr 28;2:65. (PMID: 19400956) Substance Nomenclature: 0 (Basic Helix-Loop-Helix Transcription Factors) ; 0 (DNA-Binding Proteins) ; 0 (Da protein, Drosophila) ; 0 (Drosophila Proteins) ; 0 (E(spl)m7-HLH protein, Drosophila) ; 0 (Repressor Proteins) ; 0 (Transcription Factors) ; 0 (sc protein, Drosophila) Entry Date(s): Date Created: 20120906 Date Completed: 20130103 Latest Revision: 20211021 Update Code: 20231215 PubMed Central ID: PMC3486190

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Essential roles of Da transactivation domains in neurogenesis and in E(spl)-mediated repression.