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Background: Metabolic abnormalities have a cumulative effect on development of diabetes, but only central obesity has been defined as the essential criterion of metabolic syndrome (MetS) by the International Diabetes Federation. We hypothesized that central obesity contributes to a higher risk of new-onset diabetes than other metabolic abnormalities in the hypertensive families.

Methods: Non-diabetic Chinese were enrolled and MetS components were assessed to establish baseline data in a hypertensive family-based cohort study. Based on medical records and glucose tolerance test (OGTT), the cumulative incidence of diabetes was analyzed in this five-year study by Cox regression models. Contribution of central obesity to development of new-onset diabetes was assessed in subjects with the same number of positive MetS components.

Results: Among the total of 595 subjects who completed the assessment, 125 (21.0%) developed diabetes. Incidence of diabetes increased in direct proportion to the number of positive MetS components (P ≪ 0.001). Although subjects with central obesity had a higher incidence of diabetes than those without (55.7 vs. 30.0 events/1000 person-years, P ≪ 0.001), the difference became non-significant after adjusting of the number of positive MetS components (hazard ratio = 0.72, 95%CI: 0.45-1.13). Furthermore, in all participants with three positive MetS components, there was no difference in the incidence of diabetes between subjects with and without central obesity (hazard ratio = 1.04, 95%CI: 0.50-2.16).

Conclusion: In Chinese hypertensive families, the incidence of diabetes in subjects without central obesity was similar to that in subjects with central obesity when they also had the same number of positive MetS components. We suggest that central obesity is very important, but not the essential component of the metabolic syndrome for predicting of new-onset diabetes. (

Trial Registration: NCT00260910, ClinicalTrials.gov).

Titel:	Central obesity is important but not essential component of the metabolic syndrome for predicting diabetes mellitus in a hypertensive family-based cohort. Results from the Stanford Asia-pacific program for hypertension and insulin resistance (SAPPHIRe) Taiwan follow-up study.
Autor/in / Beteiligte Person:	Lee, IT ; Chiu, YF ; Hwu, CM ; He, CT ; Chiang, FT ; Lin, YC ; Assimes, T ; Curb, JD ; Sheu, WH
Link:	Volltext (PDF)
Zeitschrift:	Cardiovascular diabetology, Jg. 11 (2012-04-26), S. 43
Veröffentlichung:	London : BioMed Central, [2002-, 2012
Medientyp:	academicJournal
ISSN:	1475-2840 (electronic)
DOI:	10.1186/1475-2840-11-43
Schlagwort:	Adult Asian People genetics Diabetes Mellitus ethnology Diabetes Mellitus genetics Diabetes Mellitus physiopathology Female Follow-Up Studies Humans Hypertension ethnology Hypertension genetics Hypertension physiopathology Incidence Male Metabolic Syndrome ethnology Metabolic Syndrome genetics Metabolic Syndrome physiopathology Middle Aged Obesity, Abdominal ethnology Obesity, Abdominal genetics Obesity, Abdominal physiopathology Pedigree Prognosis Proportional Hazards Models Risk Assessment Risk Factors Taiwan epidemiology Time Factors Diabetes Mellitus epidemiology Hypertension epidemiology Insulin Resistance ethnology Insulin Resistance genetics Metabolic Syndrome epidemiology Obesity, Abdominal epidemiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Language: English [Cardiovasc Diabetol] 2012 Apr 26; Vol. 11, pp. 43. <i>Date of Electronic Publication: </i>2012 Apr 26. MeSH Terms: Insulin Resistance* / ethnology ; Insulin Resistance* / genetics ; Diabetes Mellitus / epidemiology ; Hypertension / epidemiology ; Metabolic Syndrome / epidemiology ; Obesity, Abdominal / epidemiology ; Adult ; Asian People / genetics ; Diabetes Mellitus / ethnology ; Diabetes Mellitus / genetics ; Diabetes Mellitus / physiopathology ; Female ; Follow-Up Studies ; Humans ; Hypertension / ethnology ; Hypertension / genetics ; Hypertension / physiopathology ; Incidence ; Male ; Metabolic Syndrome / ethnology ; Metabolic Syndrome / genetics ; Metabolic Syndrome / physiopathology ; Middle Aged ; Obesity, Abdominal / ethnology ; Obesity, Abdominal / genetics ; Obesity, Abdominal / physiopathology ; Pedigree ; Prognosis ; Proportional Hazards Models ; Risk Assessment ; Risk Factors ; Taiwan / epidemiology ; Time Factors References: Endocrinology. 2011 Sep;152(9):3385-95. (PMID: 21750049) ; Diabetes Obes Metab. 2012 May;14(5):399-408. (PMID: 22074144) ; Endocr J. 2007 Dec;54(5):695-702. (PMID: 17785919) ; Cardiovasc Diabetol. 2011 Jan 27;10:11. (PMID: 21269524) ; Am J Hypertens. 2000 Jun;13(6 Pt 1):704-9. (PMID: 10912757) ; Diabetes. 2001 Aug;50(8):1771-7. (PMID: 11473037) ; Int J Clin Pract. 2008 Sep;62(9):1391-6. (PMID: 18557792) ; Diabetes Care. 2007 Feb;30(2):343-7. (PMID: 17259505) ; Diabetologia. 1985 Jul;28(7):412-9. (PMID: 3899825) ; Eur J Clin Invest. 1997 Sep;27(9):774-9. (PMID: 9352250) ; Diabetes Care. 2009 Dec;32(12):2288-93. (PMID: 19729523) ; J Atheroscler Thromb. 2009 Oct;16(5):627-32. (PMID: 19907104) ; Chin Med J (Engl). 2009 Nov 5;122(21):2534-9. (PMID: 19951566) ; JAMA. 2010 Jan 20;303(3):235-41. (PMID: 20071471) ; J Formos Med Assoc. 2006 Aug;105(8):626-35. (PMID: 16935763) ; Am J Hypertens. 1996 Aug;9(8):732-8. (PMID: 8862218) ; Clin Pharmacol Ther. 2010 Apr;87(4):407-16. (PMID: 20200516) ; Cardiovasc Diabetol. 2011 Apr 28;10:36. (PMID: 21526991) ; Int J Obes (Lond). 2007 Mar;31(3):528-34. (PMID: 16865099) ; Cardiovasc Diabetol. 2011 Mar 22;10:24. (PMID: 21426540) ; Diabetes Care. 2004 Sep;27(9):2222-8. (PMID: 15333488) ; Nature. 2006 Dec 14;444(7121):881-7. (PMID: 17167477) ; Int J Obes Relat Metab Disord. 1998 Sep;22(9):910-4. (PMID: 9756251) ; Circulation. 2009 Oct 20;120(16):1640-5. (PMID: 19805654) ; Metabolism. 2007 Dec;56(12):1708-13. (PMID: 17998025) ; Hypertens Res. 2006 Feb;29(2):81-7. (PMID: 16755141) ; Diab Vasc Dis Res. 2008 Jun;5(2):114-22. (PMID: 18537099) ; Arch Med Res. 2011 Apr;42(3):244-51. (PMID: 21722822) ; Diabet Med. 2011 Aug;28(8):941-7. (PMID: 21749444) ; Am J Med. 2006 Apr;119(4):318-26. (PMID: 16564774) ; Appl Physiol Nutr Metab. 2007 Feb;32(1):4-12. (PMID: 17332780) ; Diabetes. 1998 May;47(5):699-713. (PMID: 9588440) ; Diabet Med. 2009 Dec;26(12):1185-92. (PMID: 20002468) ; Diabetes Care. 2007 Sep;30(9):2349-54. (PMID: 17575088) ; Am J Cardiol. 2007 Sep 1;100(5):835-9. (PMID: 17719329) ; JAMA. 2001 May 16;285(19):2486-97. (PMID: 11368702) ; Cardiovasc Diabetol. 2011 Nov 30;10:108. (PMID: 22129309) ; J Atheroscler Thromb. 2005;12(6):295-300. (PMID: 16394610) ; Diabetes Care. 2004 May;27(5):1182-6. (PMID: 15111542) ; Circulation. 2003 Jul 29;108(4):414-9. (PMID: 12860911) ; Endocrinology. 2002 Feb;143(2):339-42. (PMID: 11796484) Molecular Sequence: ClinicalTrials.gov NCT00260910 Entry Date(s): Date Created: 20120428 Date Completed: 20121221 Latest Revision: 20221207 Update Code: 20240513 PubMed Central ID: PMC3476431

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Central obesity is important but not essential component of the metabolic syndrome for predicting diabetes mellitus in a hypertensive family-based cohort. Results from the Stanford Asia-pacific program for hypertension and insulin resistance (SAPPHIRe) Taiwan follow-up study.