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Monocytes are programmed to undergo apoptosis in the absence of stimulation. Stimuli that promote monocyte-macrophage differentiation not only cause cellular changes, but also prevent the default apoptosis of monocytes. In the present study, we demonstrate that autophagy is induced when monocytes are triggered to differentiate and that the induction of autophagy is pivotal for the survival and differentiation of monocytes. We also show that inhibition of autophagy results in apoptosis of cells that are engaged in differentiation. We found that the differentiation signal releases Beclin1 from Bcl-2 by activating JNK and blocks Atg5 cleavage, both of which are critical for the induction of autophagy. Preventing autophagy induction hampers differentiation and cytokine production; therefore, autophagy is an important transition from monocyte apoptosis to differentiation.

Titel:	Induction of autophagy is essential for monocyte-macrophage differentiation.
Autor/in / Beteiligte Person:	Zhang, Y ; Morgan, MJ ; Chen, K ; Choksi, S ; Liu, ZG
Zeitschrift:	Blood, Jg. 119 (2012-03-22), Heft 12, S. 2895-905
Veröffentlichung:	2021- : [New York] : Elsevier ; <i>Original Publication</i>: New York, Grune & Stratton [etc.], 2012
Medientyp:	academicJournal
ISSN:	1528-0020 (electronic)
DOI:	10.1182/blood-2011-08-372383
Schlagwort:	Animals Blotting, Western Cells, Cultured Flow Cytometry Humans Immunoprecipitation Mice Mice, Inbred C57BL Microscopy, Confocal Microscopy, Electron, Transmission Real-Time Polymerase Chain Reaction Signal Transduction physiology Autophagy physiology Cell Differentiation physiology Macrophages cytology Monocytes cytology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Intramural Language: English [Blood] 2012 Mar 22; Vol. 119 (12), pp. 2895-905. <i>Date of Electronic Publication: </i>2012 Jan 05. MeSH Terms: Autophagy / physiology ; Cell Differentiation / physiology ; Macrophages / cytology ; Monocytes / cytology ; Animals ; Blotting, Western ; Cells, Cultured ; Flow Cytometry ; Humans ; Immunoprecipitation ; Mice ; Mice, Inbred C57BL ; Microscopy, Confocal ; Microscopy, Electron, Transmission ; Real-Time Polymerase Chain Reaction ; Signal Transduction / physiology Comments: Comment in: Blood. 2012 Mar 22;119(12):2699-700. (PMID: 22442330) References: Mol Cell Biol. 2009 Aug;29(16):4376-93. (PMID: 19528235) ; J Exp Med. 1968 Sep 1;128(3):415-35. (PMID: 5666958) ; J Biol Chem. 2008 Sep 12;283(37):25596-25605. (PMID: 18628207) ; Cell. 2010 Feb 5;140(3):313-26. (PMID: 20144757) ; Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19860-5. (PMID: 19910529) ; Nature. 2011 Jan 20;469(7330):323-35. (PMID: 21248839) ; Nature. 2000 Aug 24;406(6798):902-6. (PMID: 10972293) ; Nature. 2008 Jul 10;454(7201):232-5. (PMID: 18454133) ; Autophagy. 2008 Jul;4(5):600-6. (PMID: 18497563) ; J Biol Chem. 2005 May 27;280(21):20722-9. (PMID: 15778222) ; Science. 2003 Sep 5;301(5638):1387-91. (PMID: 12958363) ; EMBO J. 2010 Jan 6;29(1):27-40. (PMID: 19893488) ; Neuron. 2003 Oct 9;40(2):401-13. (PMID: 14556717) ; J Immunol. 2009 Apr 1;182(7):4046-55. (PMID: 19299702) ; Mol Cell. 2008 Jun 20;30(6):678-88. (PMID: 18570871) ; J Exp Med. 2011 Mar 14;208(3):455-67. (PMID: 21339326) ; Nat Rev Cancer. 2005 Sep;5(9):726-34. (PMID: 16148885) ; Nature. 2004 Dec 23;432(7020):1032-6. (PMID: 15525940) ; J Biol Chem. 2009 Aug 7;284(32):21412-24. (PMID: 19520853) ; Dev Cell. 2004 Apr;6(4):463-77. (PMID: 15068787) ; J Exp Med. 1997 Apr 21;185(8):1511-6. (PMID: 9126933) ; Trends Immunol. 2004 Dec;25(12):677-86. (PMID: 15530839) ; Nature. 2003 Dec 11;426(6967):620. (PMID: 14668850) ; Nature. 2008 Feb 28;451(7182):1069-75. (PMID: 18305538) ; Nat Cell Biol. 2010 Sep;12(9):823-30. (PMID: 20811354) ; J Clin Invest. 2009 Nov;119(11):3329-39. (PMID: 19855132) ; Cell Tissue Kinet. 1972 Jul;5(4):311-7. (PMID: 5044622) ; Nat Rev Mol Cell Biol. 2007 Sep;8(9):741-52. (PMID: 17717517) ; Cell. 2005 Sep 23;122(6):927-39. (PMID: 16179260) ; Autophagy. 2009 Jul;5(5):625-35. (PMID: 19276668) ; Nat Cell Biol. 2006 Oct;8(10):1124-32. (PMID: 16998475) ; Nature. 2008 Jul 24;454(7203):436-44. (PMID: 18650914) ; Am J Respir Cell Mol Biol. 2007 Jan;36(1):68-77. (PMID: 16931806) ; Cell Mol Immunol. 2008 Apr;5(2):153-7. (PMID: 18445346) ; Rheumatology (Oxford). 2006 Jun;45(6):703-10. (PMID: 16418198) ; Cell Death Differ. 2000 Dec;7(12):1263-9. (PMID: 11175264) ; J Exp Med. 1999 Dec 6;190(11):1679-88. (PMID: 10587358) ; Autophagy. 2010 Jan;6(1):61-6. (PMID: 19901552) ; Oncogene. 2010 Mar 25;29(12):1717-9. (PMID: 20101204) ; Cell Death Differ. 2007 Jul;14(7):1247-50. (PMID: 17431417) ; J Autoimmun. 2009 Nov-Dec;33(3-4):222-30. (PMID: 19819674) ; Eukaryot Cell. 2002 Feb;1(1):11-21. (PMID: 12455967) ; Autophagy. 2007 Jan-Feb;3(1):57-9. (PMID: 17102581) ; J Pharmacol Sci. 2007 Dec;105(4):317-25. (PMID: 18094523) ; Nat Rev Immunol. 2007 Oct;7(10):767-77. (PMID: 17767194) ; Cell Host Microbe. 2009 Sep 17;6(3):231-43. (PMID: 19748465) ; J Immunol. 1996 May 1;156(9):3469-77. (PMID: 8617975) ; Nat Immunol. 2010 Sep;11(9):799-805. (PMID: 20711193) ; Autophagy. 2008 Apr;4(3):309-14. (PMID: 18188005) ; J Cell Biol. 2001 Feb 19;152(4):657-68. (PMID: 11266458) Grant Information: United States Intramural NIH HHS Entry Date(s): Date Created: 20120107 Date Completed: 20120507 Latest Revision: 20211021 Update Code: 20231215 PubMed Central ID: PMC3327464

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Induction of autophagy is essential for monocyte-macrophage differentiation.