Einzeltreffer — DigiBib

The lens-specific reglatory element of the delta 1-crystallin enhancer lies within the core segment (Goto et al., (1990) Mol. Cell. Biol. 10, 935-964). The element was allocated within the 55 bp long HN fragment of the core. Block-wise base substitutions were introduced to the 55 bp and their effect on the enhancer activity of the multimers in lens cells was examined. By base sequence alteration of either of the contiguous blocks 5 and 6, with their original sequence of TTGCT and CACCT, respectively, enhancer activity was totally lost. A lens nuclear factor delta EF1 was found which bound specifically to the base sequences defined by the blocks. DNA binding activity very similar to delta EF1 was also found in extracts of tissues other than lens, suggesting that delta EF1 participates in lens-specific regulation through tissue-dependent modification or interaction with other factors.

Titel:	Identification of nuclear factor delta EF1 and its binding site essential for lens-specific activity of the delta 1-crystallin enhancer.
Autor/in / Beteiligte Person:	Funahashi, J ; Kamachi, Y ; Goto, K ; Kondoh, H
Zeitschrift:	Nucleic acids research, Jg. 19 (1991-07-11), Heft 13, S. 3543-7
Veröffentlichung:	1992- : Oxford : Oxford University Press ; <i>Original Publication</i>: London, Information Retrieval ltd., 1991
Medientyp:	academicJournal
ISSN:	0305-1048 (print)
DOI:	10.1093/nar/19.13.3543
Schlagwort:	Animals Base Sequence Binding Sites Cells, Cultured Chick Embryo Chloramphenicol O-Acetyltransferase genetics DNA Mutational Analysis Gene Expression Regulation Macromolecular Substances Molecular Sequence Data Transfection genetics Crystallins genetics DNA-Binding Proteins metabolism Enhancer Elements, Genetic physiology Lens, Crystalline metabolism Nuclear Proteins metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Nucleic Acids Res] 1991 Jul 11; Vol. 19 (13), pp. 3543-7. MeSH Terms: Crystallins / genetics ; DNA-Binding Proteins / metabolism ; Enhancer Elements, Genetic / physiology ; Lens, Crystalline / metabolism ; Nuclear Proteins / *metabolism ; Animals ; Base Sequence ; Binding Sites ; Cells, Cultured ; Chick Embryo ; Chloramphenicol O-Acetyltransferase / genetics ; DNA Mutational Analysis ; Gene Expression Regulation ; Macromolecular Substances ; Molecular Sequence Data ; Transfection / genetics References: Cell. 1988 Sep 9;54(6):855-64. (PMID: 3044613) ; Proc Natl Acad Sci U S A. 1976 Aug;73(8):2808-12. (PMID: 1066691) ; Cell. 1990 Feb 9;60(3):375-86. (PMID: 2302733) ; Mol Cell Biol. 1990 Jul;10(7):3700-8. (PMID: 1694016) ; Proc Natl Acad Sci U S A. 1990 Feb;87(3):1099-103. (PMID: 1967834) ; Mol Cell Biol. 1990 Mar;10(3):982-90. (PMID: 2304473) ; Mol Cell Biol. 1990 Mar;10(3):958-64. (PMID: 2304470) ; Nucleic Acids Res. 1983 Mar 11;11(5):1475-89. (PMID: 6828386) ; Nature. 1983 Feb 3;301(5899):440-2. (PMID: 6823321) ; Differentiation. 1981;19(3):134-53. (PMID: 7030840) ; Mol Cell Biol. 1990 Dec;10(12):6204-15. (PMID: 2123291) ; Mol Cell Biol. 1991 Mar;11(3):1531-7. (PMID: 1996107) ; Cell. 1990 Nov 16;63(4):815-25. (PMID: 2121368) ; Nature. 1987 Sep 10-16;329(6135):174-8. (PMID: 3627254) ; Genes Dev. 1987 Oct;1(8):818-28. (PMID: 2828173) ; EMBO J. 1985 Sep;4(9):2201-7. (PMID: 3000763) ; Nucleic Acids Res. 1985 Mar 11;13(5):1593-606. (PMID: 2987831) ; J Biol Chem. 1985 Aug 5;260(16):9100-5. (PMID: 3839507) Substance Nomenclature: 0 (Crystallins) ; 0 (DNA-Binding Proteins) ; 0 (Macromolecular Substances) ; 0 (Nuclear Proteins) ; EC 2.3.1.28 (Chloramphenicol O-Acetyltransferase) Entry Date(s): Date Created: 19910711 Date Completed: 19910820 Latest Revision: 20190501 Update Code: 20231215 PubMed Central ID: PMC328377

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Identification of nuclear factor delta EF1 and its binding site essential for lens-specific activity of the delta 1-crystallin enhancer.