Skin penetration of terpenes from essential oils and topical vehicles.
In: Planta medica, Jg. 72 (2006-03-01), Heft 4, S. 311-6
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Zugriff:
The purpose of this study was to evaluate the in vitro cutaneous penetration of five terpenes--linalool, linalyl acetate, terpinen-4-ol, citronellol and alpha-pinene--applied in pure essential oils or in dermatological formulations (o/w emulsion, oily solution or hydrogel) containing 0.75 % w/w of the essential oils. Different skin absorption was observed depending on the type of the vehicle and terpenes' log P values. Cutaneous accumulation of terpenes is several times higher when they are applied in pure essential oils than in topical vehicles. Penetration of terpinen-4-ol to the skin was better from an oily solution (approximately 90 microg/cm (2)) than from an emulsion (60 microg/cm (2)). No penetration of linalyl acetate from topical vehicles into viable skin was observed, but also for this terpene penetration to the upper layers of the stratum corneum was 2-times higher when an oily solution was used. In contrast, the cutaneous absorption of linalool was the same from both vehicles (50-60 microg/cm (2)). The skin penetration of alpha-pinene was not traceable when it was applied in an oily solution. Only a small amount (approximately 5 microg/cm (2)) of this terpene was determined in viable skin after application as a hydrogel. Citronellol applied in a hydrogel penetrated into all skin layers in a total amount of 25 microg/cm (2), while no penetration into viable skin layers after application of an oily solution was noted. Only citronellol permeated into the acceptor medium.
Titel: |
Skin penetration of terpenes from essential oils and topical vehicles.
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Autor/in / Beteiligte Person: | Cal, K |
Zeitschrift: | Planta medica, Jg. 72 (2006-03-01), Heft 4, S. 311-6 |
Veröffentlichung: | Stuttgart ; New York : George Thieme ; <i>Original Publication</i>: Stuttgart, Hippokrates Verlag., 2006 |
Medientyp: | academicJournal |
ISSN: | 0032-0943 (print) |
DOI: | 10.1055/s-2005-916230 |
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