[Insulin resistance and arterial hypertension. Hyperinsulinism as a basic etiopathogenic factor in essential arterial hypertension and associated phenomena].
In: Vnitrni lekarstvi, Jg. 38 (1992-09-01), Heft 9, S. 868-78
academicJournal
Zugriff:
In 50 normotonic patients with type 2 diabetes (NIDDM) and controls matched for sex and age with NIDDM and hypertension a statistically significant difference was found as regards S-peptide values on fasting, cholesterol, triglycerides, BMI and atherogenic index (cholesterol/HDL, p < 0.01). C-peptide values correlated positively with values of the systolic and median BP and the atherogenic index in both groups. In normotonic diabetics there was also a positive correlation with the BMI and in hypertonic subjects with the triglyceride levels. The results confirm the hypothesis that in NIDDM there is a direct relationship between arterial hypertension, unfavourable lipid parameters and insulin resistance and compensatory hyperinsulinism resp. The authors discuss possible mechanisms by which hyperinsulinism mediates a rise of BP, hyperlipoproteinaemia, hyperglycaemia and hirsutism (hormonal metabolic syndrome X and 5H resp.). These phenomena are the main risk factors of cardiovascular diseases and lead via heart attacks and cerebrovascular attacks (IHD and stroke) to a high cardiovascular morbidity and mortality in our population. The morbidity and mortality is steadily increasing and thus we are among civilized countries among those with the highest morbidity and mortality.
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[Insulin resistance and arterial hypertension. Hyperinsulinism as a basic etiopathogenic factor in essential arterial hypertension and associated phenomena].
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Autor/in / Beteiligte Person: | Hrnciar, J ; Hrnciarová, M ; Jakubíková, K ; Korónyi, S |
Zeitschrift: | Vnitrni lekarstvi, Jg. 38 (1992-09-01), Heft 9, S. 868-78 |
Veröffentlichung: | 2010- : Brno : Ambit Media ; <i>Original Publication</i>: 1973-<1994> : Praha : Avicenum, 1992 |
Medientyp: | academicJournal |
ISSN: | 0042-773X (print) |
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