Chemical analysis and antifungal activity of the essential oil of Calea clematidea.
In: Planta medica, Jg. 68 (2002-09-01), Heft 9, S. 836-8
report
Zugriff:
The chemical composition of the essential oils of Calea clematidea Baker obtained by hydrodistillation of the leaves and flowers was analysed by GC and GC/MS and the oils were assayed for their antifungal activities. The essential oil of the leaves showed a high content of a new natural epoxy terpenoid, named clemateol (ca. 70 %), with minor amounts of o-vanillin (6.5 %), spathulenol (4.2 %), alpha-terpinene (4.0 %), germacrene B (2.9 %), yomogi alcohol (1.8 %), ( E)-caryophylene (1.7 %), m-cymenene (1.6 %), and alpha-gurjunene (1.5 %), while the essential oil of the flowers was characterized by a higher content of thymol methyl ether (ca. 80 %), with minor amounts of clemateol (4.8 %) and o-cymene (4.7 %). The antimicrobial activity of the oils was also evaluated against dermatophytes for their possible use in pharmaceutical preparations for topical applications. The oil of the leaves (MIC > 3.57 mg/ml), clemateol (MIC > 1.52 mg/ml), and the alcohol 2 (MIC > 2.82 mg/ml) showed a moderate antifungal activity against Trichophyton tonsurans, Trichophyton rubrum, Trichophyton menthagrophytes var. i nterdigitale, Epidermophyton floccosum, Microsporum gypseum, Microsporum canis and Microsporum nanum.
Titel: |
Chemical analysis and antifungal activity of the essential oil of Calea clematidea.
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Autor/in / Beteiligte Person: | Flach, A ; Gregel, B ; Simionatto, E ; da Silva UF ; Zanatta, N ; Morel, AF ; Linares, CE ; Alves, SH |
Zeitschrift: | Planta medica, Jg. 68 (2002-09-01), Heft 9, S. 836-8 |
Veröffentlichung: | Stuttgart ; New York : George Thieme ; <i>Original Publication</i>: Stuttgart, Hippokrates Verlag., 2002 |
Medientyp: | report |
ISSN: | 0032-0943 (print) |
DOI: | 10.1055/s-2002-34414 |
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