[Metabolic effects of changes in dietary sodium intake in patients with essential hypertension].
In: Minerva urologica e nefrologica = The Italian journal of urology and nephrology, Jg. 52 (2000-03-01), Heft 1, S. 13-6
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Zugriff:
Background: To evaluate the metabolic effects of modification of sodium intake in patients with essential hypertension.
Methods: Thirteen patients with essential hypertension (10 M, median age 51 yrs, range 21-64) followed in random order a low-sodium and a high-sodium diet (50 mmol Na/day vs 250 mmol/day for two weeks each). At the end of each diet an evaluation was made of 24 hour blood pressure (ABPM, Spacelabs 90207) and serum concentration of: glucose, total and HDL cholesterol, uric acid, lipoproteins A, B, Lp(a), total proteins, albumin.
Results: Twenty-four hours systolic and diastolic BP were significantly higher at the end of high sodium diet than of low sodium diet [respectively 132 mmHg (120-161) vs 128 mmHg (109-150); p = 0.008 and 84 mmHg (71-99) vs 81 mmHg (70-95); p = 0.008)]. No significant variations were found as regards serum glucose and lipidic parameters between low and high sodium diets. Serum uric acid was significantly higher following low sodium diet [5.9 mg/dl (4.5-8) vs 4.6 mg/dl (3.4-6.5); p = 0.003)], as well as serum total proteins [7.2 g/dl (6.9-8.2) vs 7 g/dl (6.5-7.8); p = 0.027)]. A significant direct correlation was found between changes of uric acid and total proteins from low to high sodium diet (Spearman's rho = 0.57; p = 0.04).
Conclusions: In patients with essential hypertension a moderate dietary sodium restriction, able to reduce significantly 24 hours arterial pressure, does not worsen serum glucose nor lipids concentration.
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[Metabolic effects of changes in dietary sodium intake in patients with essential hypertension].
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Autor/in / Beteiligte Person: | Boero, R ; Pignataro, A ; Bancale, E ; Campo, A ; Morelli, E ; Nigra, M ; Novarese, M ; Possamai, D ; Prodi, E ; Quarello, F |
Zeitschrift: | Minerva urologica e nefrologica = The Italian journal of urology and nephrology, Jg. 52 (2000-03-01), Heft 1, S. 13-6 |
Veröffentlichung: | [Torino] : Edizioni Minerva medica, 1984-2020., 2000 |
Medientyp: | academicJournal |
ISSN: | 0393-2249 (print) |
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