Medical management of a large aortic thrombus in a young woman with essential thrombocythemia.
In: Mayo Clinic proceedings, Jg. 76 (2001-04-01), Heft 4, S. 427-31
academicJournal
Zugriff:
Aortic thrombus formation is rare in the patients with essential thrombocytosis (ET); therefore, no guidelines for its management have been established. Embolism from ET-associated large vessel thrombi is potentially lethal and has been managed surgically in a few reported cases. We describe herein a 45-year-old black woman with ET found to have a 3.5-cm, pedunculated intra-aortic thrombus at the thoracoabdominal junction. How to treat this potentially devastating aortic thrombus was a management dilemma. We believed, based on the patient's diagnosis of ET and the histology of similar thrombi in 1 reported series, that the aortic thrombus was a "white thrombus" consisting primarily of aggregated platelets with a minimal fibrin network and almost no entrapped erythrocytes. The patient was treated with aspirin, 325 mg daily, as a platelet antiaggregating agent and hydroxyurea, 1,500 mg daily, to reduce the platelet count to less than 450 x 10(9)/L. The thrombus resolved without severe thromboembolic events. To our knowledge, this is the first reported case of a large intra-aortic thrombosis associated with ET that has been successfully managed with medical therapy alone.
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Medical management of a large aortic thrombus in a young woman with essential thrombocythemia.
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Autor/in / Beteiligte Person: | Fang, M ; Agha, S ; Lockridge, L ; Lee, R ; Cleary, JP ; Mazur, EM |
Zeitschrift: | Mayo Clinic proceedings, Jg. 76 (2001-04-01), Heft 4, S. 427-31 |
Veröffentlichung: | Jan. 2012- : [Oxford, England] : Elsevier ; <i>Original Publication</i>: Rochester, MN : Mayo Foundation for Medical Education and Research, 2001 |
Medientyp: | academicJournal |
ISSN: | 0025-6196 (print) |
DOI: | 10.4065/76.4.427 |
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