Pipobroman is safe and effective treatment for patients with essential thrombocythaemia at high risk of thrombosis.
In: British Journal of Haematology, Jg. 116 (2002-03-15), Heft 4, S. 855-861
academicJournal
Zugriff:
Summary. Essential thrombocythaemia (ET) is a disease associated with an elevated risk of thrombosis. This study evaluated the efficacy and safety of pipobroman (PB) in the long-term control of ET patients who had, at diagnosis, one or more of the following currently known risk factors for thrombosis or haemorrhage (high-risk patients): age > 60 years, history of thrombosis or haemorrhage, platelets > 1000 × 109 /l. From 1978 to 2000, with a median follow-up of 10 years, 118 previously untreated high-risk ET patients (median age 62 years, range 25–82), were treated with PB at the starting dose of 0·8–1 mg/kg/d. All patients reached a platelet count < 600 × 109 /l and 91% achieved a platelet count < 400 × 109 /l. During follow-up, 13 patients had thrombosis, with a 10-year cumulative risk of 14%. Acute myeloid leukaemia, myelofibrosis and solid tumours occurred in three, two and seven patients with a 10-year cumulative risk of 3%, 2% and 7% respectively. Actuarial survival at 20 years was 64% and the standardized mortality ratio was 1·1 (95% CI: 0·7–1·7), not statistically different from the general population (P = 0·54). Age was associated with a higher risk of death (P = 0·00009) and thrombosis (P = 0·003). The duration of PB treatment did not correlate with the occurrence of second malignancies. This study, with a median follow-up of 10 years, demonstrates that pipobroman is effective and well tolerated. The low cumulative 10-year risk of thrombosis, leukaemia and solid tumours indicates that pipobroman is an adequate treatment for patients with high risk ET. [ABSTRACT FROM AUTHOR]
Titel: |
Pipobroman is safe and effective treatment for patients with essential thrombocythaemia at high risk of thrombosis.
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Autor/in / Beteiligte Person: | Passamonti, Francesco ; Malabarba, Lucia ; Orlandi, Ester ; Pascutto, Cristiana ; Brusamolino, Ercole ; Astori, Cesare ; Baratè, Claudia ; Canevari, Angelo ; Corso, Alessandro ; Bernasconi, Paolo ; Cazzola, Mario ; Lazzarino, Mario |
Zeitschrift: | British Journal of Haematology, Jg. 116 (2002-03-15), Heft 4, S. 855-861 |
Veröffentlichung: | 2002 |
Medientyp: | academicJournal |
ISSN: | 0007-1048 (print) |
DOI: | 10.1046/j.0007-1048.2002.03367.x |
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