How essential is cholesterol?
In: Biochemical Journal, Jg. 420 (2009-05-13), Heft 2, S. e1- (4S.)
academicJournal
Zugriff:
Cholesterol is an apparently indispensable lipid for numerous processes required for cell proliferation. Levels of this molecule are primarily regulated at the transcriptional level by the SREBPs (sterol-regulatory-element-binding proteins) and LXR (liver X receptor). In this issue of the Biochemical Journal, Rodríguez-Acebes et al. show that a cholesterol precursor, desmosterol, can support cell proliferation in the absence of cholesterol in a murine macrophage-like model (J774-D cells). These cells are defective in DHCR24 (sterol-Δ24-reductase, or 3β-hydroxysterol Δ24-reductase), leading to desmosterol accumulation, and yet sterol homoeostasis appears to be normal with respect to SREBP processing and LXR activation. Other potentially cholesterol-dependent processes which were not the focus of this study are briefly discussed, such as lipid-raft-dependent cell signalling. [ABSTRACT FROM AUTHOR]
Titel: |
How essential is cholesterol?
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Autor/in / Beteiligte Person: | Stevenson, Julian ; Brown, Andrew J. |
Zeitschrift: | Biochemical Journal, Jg. 420 (2009-05-13), Heft 2, S. e1- (4S.) |
Veröffentlichung: | 2009 |
Medientyp: | academicJournal |
ISSN: | 0264-6021 (print) |
DOI: | 10.1042/BJ20090445 |
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