Achtung:
Umleitung auf bevorzugte Datensatz-ID: asx:176574468 → asx:178095986
Magnetic Resonance‐Guided Focused Ultrasound (MRgFUS)‐Thalamotomy for Essential Tremor: Lesion Location and Clinical Outcomes.
In: Movement Disorders, Jg. 39 (2024-06-01), Heft 6, S. 1015-1025
academicJournal
Zugriff:
Background: Factors predicting clinical outcomes after MR‐guided focused ultrasound (MRgFUS)‐thalamotomy in patients with essential tremor (ET) are not well known. Objective: To examine the clinical outcomes and their relationship with patients' baseline demographic and clinical features and lesion characteristics at 6‐month follow‐up in ET patients. Methods: A total of 127 patients were prospectively evaluated at 1 (n = 122), 3 (n = 102), and 6 months (n = 78) after MRgFUS‐thalamotomy. Magnetic resonance imaging (MRI) was obtained at 6 months (n = 60). Primary outcomes included: (1) change in the Clinical Rating Scale of Tremor (CRST)‐A+B score in the treated hand and (2) frequency and severity of adverse events (AEs) at 6 months. Secondary outcomes included changes in all subitems of the CRST scale in the treated hand, CRST‐C, axial tremor (face, head, voice, tongue), AEs, and correlation of primary outcomes at 6 months with lesion characteristics. Statistical analysis included linear mixed, standard, and logistic regression models. Results: Scores for CRST‐A+B, CRST‐A, CRST‐B in the treated hand, CRST‐C, and axial tremor were improved at each evaluation (P < 0.001). Five patients had severe AEs at 1 month that became mild throughout the follow‐up. Mild AEs occurred in 71%, 45%, and 34% of patients at 1, 3, and 6 months, respectively. Lesion volume was associated with the reduction in the CRST‐A (P = 0.003) and its overlapping with the ventralis intermedius nucleus (Vim) nucleus with the reduction in CRST‐A+B (P = 0.02) and CRST‐B (P = 0.008) at 6 months. Conclusions: MRgFUS‐thalamotomy improves hand and axial tremor in ET patients. Transient and mild AEs are frequent. Lesion volume and location are associated with tremor reduction. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]
Titel: |
Magnetic Resonance‐Guided Focused Ultrasound (MRgFUS)‐Thalamotomy for Essential Tremor: Lesion Location and Clinical Outcomes.
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Autor/in / Beteiligte Person: | Arcadi, Alana ; Aviles‐Olmos, Iciar ; Gonzalez‐Quarante, Lain Hermes ; Gorospe, Arantza ; Jiménez‐Huete, Adolfo ; de la Corte, Marta Macías ; Parras, Olga ; Martin‐Bastida, Antonio ; Riverol, Mario ; Villino, Rafael ; Guridi, Jorge ; Rodríguez‐Oroz, Maria C. |
Zeitschrift: | Movement Disorders, Jg. 39 (2024-06-01), Heft 6, S. 1015-1025 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 0885-3185 (print) |
DOI: | 10.1002/mds.29801 |
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