The Essential Oil of Citrus lumia Risso and Poit. 'Pyriformis' Shows Promising Antioxidant, Anti-Inflammatory, and Neuromodulatory Effects.
In: International Journal of Molecular Sciences, Jg. 24 (2023-03-15), Heft 6, S. 5534-5553
academicJournal
Zugriff:
Citrus lumia Risso and Poit. 'Pyriformis' are horticultural varieties of Citrus lumia Risso. The fruit is very fragrant and pear-shaped, with a bitter juice, a floral flavor, and a very thick rind. The flavedo shows enlarged (0.74 × 1.16 mm), spherical and ellipsoidal secretory cavities containing the essential oil (EO), visible using light microscopy, and more evident using scanning electron microscopy. The GC-FID and GC-MS analyses of the EO showed a phytochemical profile characterized by the predominance of D-limonene (93.67%). The EO showed interesting antioxidant and anti-inflammatory activities (IC50 0.07–2.06 mg/mL), as evaluated by the in vitro cell-free enzymatic and non-enzymatic assays. To evaluate the effect on the neuronal functional activity, the embryonic cortical neuronal networks grown on multi-electrode array chips were exposed to non-cytotoxic concentrations of the EO (5–200 µg/mL). The spontaneous neuronal activity was recorded and the mean firing rate, mean burst rate, percentage of spikes in a burst, mean burst durations and inter-spike intervals within a burst parameter were calculated. The EO induced strong and concentration-dependent neuroinhibitory effects, with IC50 ranging between 11.4–31.1 µg/mL. Furthermore, it showed an acetylcholinesterase inhibitory activity (IC50 0.19 mg/mL), which is promising for controlling some of the key symptoms of neurodegenerative diseases such as memory and cognitive concerns. [ABSTRACT FROM AUTHOR]
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The Essential Oil of Citrus lumia Risso and Poit. 'Pyriformis' Shows Promising Antioxidant, Anti-Inflammatory, and Neuromodulatory Effects.
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Autor/in / Beteiligte Person: | Smeriglio, Antonella ; Alloisio, Susanna ; Barbieri, Raffaella ; Ingegneri, Mariarosaria ; Malaspina, Paola ; Burlando, Bruno ; Cornara, Laura ; Trombetta, Domenico |
Zeitschrift: | International Journal of Molecular Sciences, Jg. 24 (2023-03-15), Heft 6, S. 5534-5553 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1661-6596 (print) |
DOI: | 10.3390/ijms24065534 |
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