USP39 is essential for mammalian epithelial morphogenesis through upregulation of planar cell polarity components.
In: Communications Biology, Jg. 5 (2022-04-19), Heft 1, S. 1-18
academicJournal
Zugriff:
Previously, we have shown that the translocation of Grainyhead-like 3 (GRHL3) transcription factor from the nucleus to the cytoplasm triggers the switch from canonical Wnt signaling for epidermal differentiation to non-canonical Wnt signaling for epithelial morphogenesis. However, the molecular mechanism that underlies the cytoplasmic localization of GRHL3 protein and that activates non-canonical Wnt signaling is not known. Here, we show that ubiquitin-specific protease 39 (USP39), a deubiquitinating enzyme, is involved in the subcellular localization of GRHL3 as a potential GRHL3-interacting protein and is necessary for epithelial morphogenesis to up-regulate expression of planar cell polarity (PCP) components. Notably, mouse Usp39-deficient embryos display early embryonic lethality due to a failure in primitive streak formation and apico-basal polarity in epiblast cells, resembling those of mutant embryos of the Prickle1 gene, a crucial PCP component. Current findings provide unique insights into how differentiation and morphogenesis are coordinated to construct three-dimensional complex structures via USP39. The ubiquitin specific protease 39 (USP39) interacts with the transcription factor and cytoplasmic regulator of planar cell polarity (PCP), Grainyheadlike 3 (Grhl3). USP39-dependent PCP gene upregulation contributes to epithelial morphogenesis. [ABSTRACT FROM AUTHOR]
Titel: |
USP39 is essential for mammalian epithelial morphogenesis through upregulation of planar cell polarity components.
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Autor/in / Beteiligte Person: | Kimura-Yoshida, Chiharu ; Mochida, Kyoko ; Kanno, Shin-Ichiro ; Matsuo, Isao |
Zeitschrift: | Communications Biology, Jg. 5 (2022-04-19), Heft 1, S. 1-18 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 2399-3642 (print) |
DOI: | 10.1038/s42003-022-03254-7 |
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