Age-related increase of pulse pressure and plasminogen activator inhibitor-1 I/D gene polymorphism in essential hypertension.
In: Journal of Internal Medicine, Jg. 257 (2005), Heft 1, S. 93-99
academicJournal
Zugriff:
Mourad J-J, du Cailar G, Nazal E-M, Safar ME, Mimran A (Avicenne Hospital-AP-HP, Bobigny; Lapeyronie Hospital, Montpellier; and Hotel Dieu Hospital, Paris, France). Age-related increase of pulse pressure and plasminogen activator inhibitor-1 I/D gene polymorphism in essential hypertension.J Intern Med2005;257:93–99.Pulse pressure (PP), a marker of cyclic strain on the arterial wall, is a significant predictor of cardiovascular (CV) risk, particularly regarding the incidence of coronary arterial stenosis. Genes related to haemostatic and/or fibrinolytic factors are consistently influencedin vitroby mechanical strain.The goal of the present study was to determine, in the three genotypes of the plasminogen activator inhibitor (PAI)-1 gene polymorphism, the gender-adjusted difference in the relationships between age and PP in subjects with never treated essential hypertension.In the studied population, the genotype deletion (D)/D at position−675 of the PAI-1 insertion (I)/D gene polymorphism was associated with a significant increase in the adjusted slope of the curve relating age to PP by comparison with the two other genotypes. No comparable difference in age-related changes in systolic, diastolic or mean blood pressure was found.In subjects with essential hypertension, the PAI-1 I/D gene polymorphism modulates the age-mediated increase of PP, suggesting new insights on the complex interactions between genes, mechanical factors and CV risk. [ABSTRACT FROM AUTHOR]
Titel: |
Age-related increase of pulse pressure and plasminogen activator inhibitor-1 I/D gene polymorphism in essential hypertension.
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Autor/in / Beteiligte Person: | Mourad, J. J. ; Du Cailar, G. ; Nazal, E. M. ; Safar, M. E. ; Mimran, A. |
Zeitschrift: | Journal of Internal Medicine, Jg. 257 (2005), Heft 1, S. 93-99 |
Veröffentlichung: | 2005 |
Medientyp: | academicJournal |
ISSN: | 0954-6820 (print) |
DOI: | 10.1111/j.1365-2796.2004.01427.x |
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