Chemical Composition and Anticandidal Activity of Essential Oils Obtained from Different Parts of Prangos heyniae H. Duman & M. F. Watson.

The chemical compositions and anticandidal activities of the essential oils from the aerial parts, inflorescence, and roots of the endemic P. heyniae H. Duman & M. F. Watson were evaluated. Hydrodistillation was used to isolate the essential oils and the chemical analyses were performed both by GC-FID and GC/MS, respectively. Forty-four compounds constituting 94.4% of aerial parts, thirty-nine compounds constituting 99.5% of inflorescence, and twenty-five compounds representing 100.0% of root essential oil were characterized. The main compounds of the aerial parts oil were elemol (36.2%), β-bisabolenal (14.1%), and germacrene D (12.7%). Main compounds of inflorescence oil were β-bisabolenal (21.6%) germacrene D (15.6%), and germacrene B (12.4%) while the roots oil were α-pinene (44.8%), limonene (15.3%), α -pinene (12.5%), and δ-3-carene (10.2%), respectively. The in vitro anticandidal activity of the essential oils were evaluated against several Candida strains by using partly modified CLSI broth microdilution method M27-A2. The tested essential oil showed relatively weak effects against pathogenic Candida strains compared to standard antifungal agents. [ABSTRACT FROM AUTHOR]