Clinical-Instrumental patterns of neurodegeneration in Essential Tremor: A data-driven approach.
In: Parkinsonism & Related Disorders, Jg. 87 (2021-06-01), S. 124-129
academicJournal
Zugriff:
Introduction: Essential Tremor (ET) is increasingly recognized as a complex disorder with additional clinical signs other than tremor. It is still unknown whether a unique pathophysiologic or neurodegenerative process underlies progression and prognosis of the disease. The aim of the study was to identify ET phenotypes through a clinical-instrumental data-driven approach and to characterize possible patterns of neurodegeneration. Methods: ET patients were categorized using spatio-temporal and kinematic variables related to mobility and dynamic stability processed by motion transducers. Differences between the identified groups in clinical-demographic variables, neuropsychological performances and retinal parameters by Optical Coherence Tomography (OCT) segmentation analysis were tested. Results: Twenty-five ET patients were studied. Based on clustering of kinematic and spatio-temporal gait parameters, two independent groups were identified: cluster "A" (N = 15) and cluster "B" (N = 10). Compared to group A, group B had overall worse performance in mobility, especially on turning tasks. Identified clusters did not differ in terms of age, age at onset and disease duration. Patients in group B had more head tremor and more severe action tremor in the upper limbs as compared to group A, demonstrating also worse performances on cognitive assessments. Based on OCT analysis, group B presented a reduced thickness of the retinal inner layer as compared to group A, suggesting underlying neurodegenerative processes. Conclusions: The presence of gait and mobility impairment, associated with midline tremor, cognitive decline and retinal degeneration suggests a subtype of ET associated with neurodegeneration. [ABSTRACT FROM AUTHOR]
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Clinical-Instrumental patterns of neurodegeneration in Essential Tremor: A data-driven approach.
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Autor/in / Beteiligte Person: | Mostile, Giovanni ; Terranova, Roberta ; Rascunà, Cristina ; Terravecchia, Claudio ; Cicero, Calogero Edoardo ; Giuliano, Loretta ; Davì, Marco ; Chisari, Clara ; Luca, Antonina ; Preux, Pierre-Marie ; Jankovic, Joseph ; Zappia, Mario ; Nicoletti, Alessandra |
Zeitschrift: | Parkinsonism & Related Disorders, Jg. 87 (2021-06-01), S. 124-129 |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 1353-8020 (print) |
DOI: | 10.1016/j.parkreldis.2021.05.011 |
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