PRV-1, erythroid colonies and platelet Mpl are unrelated to thrombosis in essential thrombocythaemia.
In: British Journal of Haematology, Jg. 127 (2004-10-11), Heft 2, S. 214-219
academicJournal
Zugriff:
Females with the monoclonal type of essential thrombocythaemia (ET), based on the X-chromosome inactivation pattern (XCIP), have previously been shown to present a higher incidence of thrombosis than polyclonal ones. We aimed to assess correlations between XCIP, thrombosis, and three epigenetic markers of ET, namelyPRV-1overexpression, endogenous erythroid colony (EEC) formation, and reduced platelet Mpl content. Fifty-three (60%) of 88 subjects studied had monoclonal myelopoiesis and presented a 32% incidence of major thrombosis compared with 6% of polyclonal subjects (P = 0·009). The frequency of abnormalities ofPRV-1, EEC, or Mpl was similar in monoclonal and polyclonal subjects (respectively, 28%, 48%, 75%, and 37%, 27%, 63%), and none of them correlated with thrombosis. We conclude that the exploited epigenetic markers constitute independent phenotypic variations and are not clustered according to monoclonality of myelopoiesis in ET; none of them could serve as a surrogate marker of thrombotic risk in male subjects with ET. [ABSTRACT FROM AUTHOR]
Titel: |
PRV-1, erythroid colonies and platelet Mpl are unrelated to thrombosis in essential thrombocythaemia.
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Autor/in / Beteiligte Person: | Vannucch, Alessandro M. ; Grossi, Alberto ; Pancrazzi, Alessandro ; Antonioli, Elisabetta ; Guglielmelli, Paola ; Balestri, Francesca ; Biscardi, Monica ; Bulgarelli, Simona ; Longo, Giovanni ; Graziano, Claudio ; Gugliotta, Luigi ; Bosi, Alberto |
Zeitschrift: | British Journal of Haematology, Jg. 127 (2004-10-11), Heft 2, S. 214-219 |
Veröffentlichung: | 2004 |
Medientyp: | academicJournal |
ISSN: | 0007-1048 (print) |
DOI: | 10.1111/j.1365-2141.2004.05175.x |
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