Dentate Nucleus Neuronal Density: A Postmortem Study of Essential Tremor Versus Control Brains.
In: Movement Disorders, Jg. 36 (2021-04-01), Heft 4, S. 995-999
academicJournal
Zugriff:
Background: Essential tremor involves the cerebellum, yet quantitative analysis of dentate nucleus neurons has not been conducted. Objectives: To quantitatively compare neuronal density or neuronal number in the dentate nucleus of essential tremor versus age‐matched controls. Methods: Using a 7‐μm thick Luxol fast blue hematoxylin and eosin‐stained paraffin section, dentate nucleus neuronal density (neurons/mm2) was determined in 25 essential tremor cases and 25 controls. We also applied a stereological approach in a subset of four essential tremor cases and four controls to estimate total dentate nucleus neuronal number. Results: Dentate nucleus neuronal density did not differ between essential tremor cases and controls (P = 0.44). Total dentate nucleus neuronal number correlated with neuronal density (P = 0.007) and did not differ between essential tremor cases and controls (P = 0.95). Conclusions: Neuronal loss, observed in the Purkinje cell population in essential tremor, did not seem to similarly involve the dentate nucleus in essential tremor. © 2020 International Parkinson and Movement Disorder Society [ABSTRACT FROM AUTHOR]
Titel: |
Dentate Nucleus Neuronal Density: A Postmortem Study of Essential Tremor Versus Control Brains.
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Autor/in / Beteiligte Person: | Hartstone, Whitney G. ; Brown, Mark H. ; Kelly, Geoffrey C. ; Tate, William J. ; Kuo, Sheng‐Han ; Dwork, Andrew J. ; Louis, Elan D. ; Faust, Phyllis L. |
Zeitschrift: | Movement Disorders, Jg. 36 (2021-04-01), Heft 4, S. 995-999 |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 0885-3185 (print) |
DOI: | 10.1002/mds.28402 |
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