藏族原发性高血压患者血管内皮功能与 糖脂代谢指标和血压变异性的关系

Objective: To study the relationship between vascular endothelial function and glycolipid metabolism indexes and blood pressure variability in Tibetan patients with essential hypertension. Methods: A total of 200 Tibetan patients with essential hypertension, who were treated in Guangzhou Red Cross Hospital Affiliated to Jinan University School of medicine from February 2017 to February 2018, were selected as research subjects. All the patients were divided into normal FMD group(FMD ≥6%)(n=48) and abnormal FMD group(FMD<6%)(n=152) according to the blood flow mediated vascular diastolic function(FMD) value of brachial artery. The basic data, the levels of glycolipid metabolism indexes and blood pressure variability indexes of the two groups were compared. The correlation between FMD and glycolipid metabolism and blood pressure variability in Tibetan patients with essential hypertension were analyzed. Results: Age and the level of fasting blood glucose in the abnormal FMD group were higher than those in the normal FMD group(P <0.05). There were no significant differences in total cholesterol, triglyceride, low density lipoprotein cholesterol(LDL-C) and high density lipoprotein cholesterol(HDL-C) between the two groups(P>0.05). The levels of daytime systolic pressure, daytime diastolic pressure, night systolic pressure, night diastolic pressure, 24 h systolic pressure and 24 h diastolic pressure in the abnormal FMD group were all higher than those in the normal FMD group(P <0.05). The results of Preason correlation analysis showed that the FMD values of Tibetan patients with essential hypertension were negatively correlated with fasting blood glucose,daytime systolic pressure, daytime diastolic pressure, night systolic pressure, night diastolic pressure, 24 h systolic pressure and 24 h diastolic pressure(P<0.05). Conclusion: The more serious damage of vascular endothelial function is in Tibetan patients with essential hypertension, the more higher levels of fasting blood glucose and blood pressure are.In clinical work,joint examination of these indicators can help assess endothelial function in Tibetan patients with essential hypertension. [ABSTRACT FROM AUTHOR]

目的:研究藏族原發性高血壓患者血管內皮功能與糖脂代謝指標和血壓變異性的關系。方法:以2017年2月-2018年2月暨南大學醫學院附屬廣州紅十字會醫院收治的200例藏族原發性高血壓患者為研究對象。將所有患者按照肱動脈血流介導的血管舒張功能(FMD)值分為正常FMD組(FMD≥6%)48例與異常FMD組(FMD<6%)152例。分別比較兩組患者的基本資料、糖脂代謝指標以及血壓變異性指標水平,并分析藏族原發性高血壓患者FMD與糖脂代謝和血壓變異性的相關性。結果:異常FMD組年齡、空腹血糖水平高于正常FMD組(P<0.05),而兩組總膽固醇、甘油三酯、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)水平對比差異均無統計學意義(P>0.05)。異常FMD組日間收縮壓、日間舒張壓、夜間收縮壓、夜間舒張壓、24h收縮壓、24h舒張壓水平均高于正常FMD組(P<0.05)。經Preason相關性分析可得:藏族原發性高血壓患者FMD值與空腹血糖、日間收縮壓、日間舒張壓、夜間收縮壓、夜間舒張壓、24h收縮壓、24h舒張壓均呈負相關關系(P<0.05)。結論:藏族原發性高血壓患者血管內皮功能受損越嚴重,其空腹血糖、血壓就越高,臨床工作中可通過聯合檢查上述指標水平,有助于評估藏族原發性高血壓患者血管內皮功能。 [ABSTRACT FROM AUTHOR]