Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity.
In: Nature Medicine, Jg. 9 (2003-05-01), Heft 5, S. 582-588
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Zugriff:
Using natural killer T (NKT) cell-deficient mice, we show here that allergen-induced airway hyperreactivity (AHR), a cardinal feature of asthma, does not develop in the absence of Va14i NKT cells. The failure of NKT cell-deficient mice to develop AHR is not due to an inability of these mice to produce type 2 T-helper (Th2) responses because NKT cell-deficient mice that are immunized subcutaneously at non-mucosal sites produce normal Th2-biased responses. The failure to develop AHR can be reversed by the adoptive transfer of tetramer-purified NKT cells producing interleukin (IL)-4 and IL-13 to Ja281-/- mice, which lack the invariant T-cell receptor (TCR) of NKT cells, or by the administration to Cd1d-/- mice of recombinant IL-13, which directly affects airway smooth muscle cells. Thus, pulmonary Va14i NKT cells crucially regulate the development of asthma and Th2-biased respiratory immunity against nominal exogenous antigens. Therapies that target Va14i NKT cells may be clinically effective in limiting the development of AHR and asthma. [ABSTRACT FROM AUTHOR]
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Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity.
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Autor/in / Beteiligte Person: | Akbari, Omid ; Stock, Philippe ; Meyer, Everett ; Kronenberg, Mitchell ; Sidobre, Stephane ; Nakayama, Toshinori ; Taniguchi, Masaru ; Grusby, Michael J. ; DeKruyff, Rosemarie H. ; Umetsu, Dale T. |
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Zeitschrift: | Nature Medicine, Jg. 9 (2003-05-01), Heft 5, S. 582-588 |
Veröffentlichung: | 2003 |
Medientyp: | academicJournal |
ISSN: | 1078-8956 (print) |
DOI: | 10.1038/nm851 |
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