Histamine N-methyltransferase Thr105Ile is not associated with Parkinson's disease or essential tremor
In: Parkinsonism & Related Disorders, Jg. 16 (2010-02-01), Heft 2, S. 112-114
academicJournal
Zugriff:
Abstract: A functional variant in the Histamine N-Methyltransferase gene (HNMT – rs11558538) resulting in a threonine to isoleucine substitution (Thr105Ile) has been shown to impair histamine degradation. Two recent studies reported that the threonine allele of this polymorphism might be a risk factor for Parkinson disease (PD) and essential tremor (ET) development. Although PD and ET are considered different entities, they share some clinical and pathological features, suggesting a possible joint etiology. In this study we assess the role of the Thr105Ile variant in PD and ET development, genotyping the variant in a North American Caucasian PD and ET case-control series. Statistical analysis did not identify any significant association between this variant and PD or ET; therefore, our findings do not support the HNMT Thr105Ile variant as a factor in disease development or a genetic link between the disorders. [Copyright &y& Elsevier]
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Histamine N-methyltransferase Thr105Ile is not associated with Parkinson's disease or essential tremor
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Autor/in / Beteiligte Person: | Keeling, Brett H. ; Vilariño-Güell, Carles ; Soto-Ortolaza, Alexandra I. ; Ross, Owen A. ; Uitti, Ryan J. ; Rajput, Alex ; Wszolek, Zbigniew K. ; Farrer, Matthew J. |
Zeitschrift: | Parkinsonism & Related Disorders, Jg. 16 (2010-02-01), Heft 2, S. 112-114 |
Veröffentlichung: | 2010 |
Medientyp: | academicJournal |
ISSN: | 1353-8020 (print) |
DOI: | 10.1016/j.parkreldis.2009.08.011 |
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